Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation
<p>Abstract</p> <p>Epigenetic modifications play a key role in the patho-physiology of many tumors and the current use of agents targeting epigenetic changes has become a topic of intense interest in cancer research. DNA methyltransferase (DNMT) inhibitors represent a promising cla...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-11-01
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| Series: | Molecular Cancer |
| Online Access: | http://www.molecular-cancer.com/content/9/1/305 |
| _version_ | 1818646443018158080 |
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| author | Popov Vladimir M Marampon Francesco Festuccia Claudio Gravina Giovanni L Pestell Richard G Zani Bianca M Tombolini Vincenzo |
| author_facet | Popov Vladimir M Marampon Francesco Festuccia Claudio Gravina Giovanni L Pestell Richard G Zani Bianca M Tombolini Vincenzo |
| author_sort | Popov Vladimir M |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Epigenetic modifications play a key role in the patho-physiology of many tumors and the current use of agents targeting epigenetic changes has become a topic of intense interest in cancer research. DNA methyltransferase (DNMT) inhibitors represent a promising class of epigenetic modulators. Research performed yielded promising anti-tumorigenic activity for these agents <it>in vitro </it>and <it>in vivo </it>against a variety of hematologic and solid tumors. These epigenetic modulators cause cell cycle and growth arrest, differentiation and apoptosis. Rationale for combining these agents with cytotoxic therapy or radiation is straightforward since the use of DNMT inhibitor offers greatly improved access for cytotoxic agents or radiation for targeting DNA-protein complex. The positive results obtained with these combined approaches in preclinical cancer models demonstrate the potential impact DNMT inhibitors may have in treatments of different cancer types. Therefore, as the emerging interest in use of DNMT inhibitors as a potential chemo- or radiation sensitizers is constantly increasing, further clinical investigations are inevitable in order to finalize and confirm the consistency of current observations.</p> <p>The present article will provide a brief review of the biological significance and rationale for the clinical potential of DNMT inhibitors in combination with other chemotherapeutics or ionizing radiation. The molecular basis and mechanisms of action for these combined treatments will be discussed herein.</p> |
| first_indexed | 2024-12-17T00:46:43Z |
| format | Article |
| id | doaj.art-e2a00072838c458d94e345ca4f84c1ca |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-17T00:46:43Z |
| publishDate | 2010-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-e2a00072838c458d94e345ca4f84c1ca2022-12-21T22:09:54ZengBMCMolecular Cancer1476-45982010-11-019130510.1186/1476-4598-9-305Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiationPopov Vladimir MMarampon FrancescoFestuccia ClaudioGravina Giovanni LPestell Richard GZani Bianca MTombolini Vincenzo<p>Abstract</p> <p>Epigenetic modifications play a key role in the patho-physiology of many tumors and the current use of agents targeting epigenetic changes has become a topic of intense interest in cancer research. DNA methyltransferase (DNMT) inhibitors represent a promising class of epigenetic modulators. Research performed yielded promising anti-tumorigenic activity for these agents <it>in vitro </it>and <it>in vivo </it>against a variety of hematologic and solid tumors. These epigenetic modulators cause cell cycle and growth arrest, differentiation and apoptosis. Rationale for combining these agents with cytotoxic therapy or radiation is straightforward since the use of DNMT inhibitor offers greatly improved access for cytotoxic agents or radiation for targeting DNA-protein complex. The positive results obtained with these combined approaches in preclinical cancer models demonstrate the potential impact DNMT inhibitors may have in treatments of different cancer types. Therefore, as the emerging interest in use of DNMT inhibitors as a potential chemo- or radiation sensitizers is constantly increasing, further clinical investigations are inevitable in order to finalize and confirm the consistency of current observations.</p> <p>The present article will provide a brief review of the biological significance and rationale for the clinical potential of DNMT inhibitors in combination with other chemotherapeutics or ionizing radiation. The molecular basis and mechanisms of action for these combined treatments will be discussed herein.</p>http://www.molecular-cancer.com/content/9/1/305 |
| spellingShingle | Popov Vladimir M Marampon Francesco Festuccia Claudio Gravina Giovanni L Pestell Richard G Zani Bianca M Tombolini Vincenzo Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation Molecular Cancer |
| title | Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation |
| title_full | Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation |
| title_fullStr | Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation |
| title_full_unstemmed | Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation |
| title_short | Biological rationale for the use of DNA methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation |
| title_sort | biological rationale for the use of dna methyltransferase inhibitors as new strategy for modulation of tumor response to chemotherapy and radiation |
| url | http://www.molecular-cancer.com/content/9/1/305 |
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