Local Delivery of β-Elemene Improves Locomotor Functional Recovery by Alleviating Endoplasmic Reticulum Stress and Reducing Neuronal Apoptosis in Rats with Spinal Cord Injury

Local Delivery of β-Elemene Improves Locomotor Functional Recovery by Alleviating Endoplasmic Reticulum Stress and Reducing Neuronal Apoptosis in Rats with Spinal Cord Injury

Background/Aims: Spinal cord injury (SCI) is a serious global problem that leads to permanent motor and sensory deficits. This study explores the anti-apoptotic and neuroprotective effects of the natural extract β-elemene in vitro and in a rat model of SCI. Methods: CCK-8 assay was used to evaluate...

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Bibliographic Details
Main Authors: Jingyu Wang, Heyangzi Li, Yucheng Ren, Ying Yao, Jue Hu, Mingzhi Zheng, Yuemin Ding, Ying-ying Chen, Yueliang Shen, Lin-lin Wang, Yongjian  Zhu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-08-01
Series:Cellular Physiology and Biochemistry
Subjects:
β-elemene
Spinal cord injury
Motor neurons
ER stress
Apoptosis
Online Access:https://www.karger.com/Article/FullText/492996

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