Pharmacokinetic Characterization of (Poly)phenolic Metabolites in Human Plasma and Urine after Acute and Short-Term Daily Consumption of Mango Pulp
Pharmacokinetic (PK) evaluation of polyphenolic metabolites over 24 h was conducted in human subjects (<i>n</i> = 13, BMI = 22.7 ± 0.4 kg/m<sup>2</sup>) after acute mango pulp (MP), vitamin C (VC) or MP + VC test beverage intake and after 14 days of MP beverage intake. Plasma...
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| Format: | Article |
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MDPI AG
2020-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/23/5522 |
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| author | Jiayi Fan Di Xiao Liyun Zhang Indika Edirisinghe Britt Burton-Freeman Amandeep K. Sandhu |
| author_facet | Jiayi Fan Di Xiao Liyun Zhang Indika Edirisinghe Britt Burton-Freeman Amandeep K. Sandhu |
| author_sort | Jiayi Fan |
| collection | DOAJ |
| description | Pharmacokinetic (PK) evaluation of polyphenolic metabolites over 24 h was conducted in human subjects (<i>n</i> = 13, BMI = 22.7 ± 0.4 kg/m<sup>2</sup>) after acute mango pulp (MP), vitamin C (VC) or MP + VC test beverage intake and after 14 days of MP beverage intake. Plasma and urine samples were collected at different time intervals and analyzed using targeted and non-targeted mass spectrometry. The maximum concentrations (C<sub>max</sub>) of gallotannin metabolites were significantly increased (<i>p</i> < 0.05) after acute MP beverage intake compared to VC beverage alone. MP + VC beverage non-significantly enhanced the C<sub>max</sub> of gallic acid metabolites compared to MP beverage alone. Pyrogallol (microbial-derived metabolite) derivatives increased (3.6%) after the 14 days of MP beverage intake compared to 24 h acute MP beverage intake (<i>p</i> < 0.05). These results indicate extensive absorption and breakdown of gallotannins to galloyl and other (poly)phenolic metabolites after MP consumption, suggesting modulation and/or acclimation of gut microbiota to daily MP intake. |
| first_indexed | 2024-03-10T14:34:28Z |
| format | Article |
| id | doaj.art-e2a442c25e8341c4833c0d16134d53e5 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T14:34:28Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e2a442c25e8341c4833c0d16134d53e52023-11-20T22:20:18ZengMDPI AGMolecules1420-30492020-11-012523552210.3390/molecules25235522Pharmacokinetic Characterization of (Poly)phenolic Metabolites in Human Plasma and Urine after Acute and Short-Term Daily Consumption of Mango PulpJiayi Fan0Di Xiao1Liyun Zhang2Indika Edirisinghe3Britt Burton-Freeman4Amandeep K. Sandhu5Department of Food Science and Nutrition, Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, IL 60616, USADepartment of Food Science and Nutrition, Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, IL 60616, USADepartment of Food Science and Nutrition, Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, IL 60616, USADepartment of Food Science and Nutrition, Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, IL 60616, USADepartment of Food Science and Nutrition, Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, IL 60616, USADepartment of Food Science and Nutrition, Center for Nutrition Research, Institute for Food Safety and Health, Illinois Institute of Technology, Chicago, IL 60616, USAPharmacokinetic (PK) evaluation of polyphenolic metabolites over 24 h was conducted in human subjects (<i>n</i> = 13, BMI = 22.7 ± 0.4 kg/m<sup>2</sup>) after acute mango pulp (MP), vitamin C (VC) or MP + VC test beverage intake and after 14 days of MP beverage intake. Plasma and urine samples were collected at different time intervals and analyzed using targeted and non-targeted mass spectrometry. The maximum concentrations (C<sub>max</sub>) of gallotannin metabolites were significantly increased (<i>p</i> < 0.05) after acute MP beverage intake compared to VC beverage alone. MP + VC beverage non-significantly enhanced the C<sub>max</sub> of gallic acid metabolites compared to MP beverage alone. Pyrogallol (microbial-derived metabolite) derivatives increased (3.6%) after the 14 days of MP beverage intake compared to 24 h acute MP beverage intake (<i>p</i> < 0.05). These results indicate extensive absorption and breakdown of gallotannins to galloyl and other (poly)phenolic metabolites after MP consumption, suggesting modulation and/or acclimation of gut microbiota to daily MP intake.https://www.mdpi.com/1420-3049/25/23/5522mangopolyphenolsgallotanninspharmacokineticsplasmaurine |
| spellingShingle | Jiayi Fan Di Xiao Liyun Zhang Indika Edirisinghe Britt Burton-Freeman Amandeep K. Sandhu Pharmacokinetic Characterization of (Poly)phenolic Metabolites in Human Plasma and Urine after Acute and Short-Term Daily Consumption of Mango Pulp Molecules mango polyphenols gallotannins pharmacokinetics plasma urine |
| title | Pharmacokinetic Characterization of (Poly)phenolic Metabolites in Human Plasma and Urine after Acute and Short-Term Daily Consumption of Mango Pulp |
| title_full | Pharmacokinetic Characterization of (Poly)phenolic Metabolites in Human Plasma and Urine after Acute and Short-Term Daily Consumption of Mango Pulp |
| title_fullStr | Pharmacokinetic Characterization of (Poly)phenolic Metabolites in Human Plasma and Urine after Acute and Short-Term Daily Consumption of Mango Pulp |
| title_full_unstemmed | Pharmacokinetic Characterization of (Poly)phenolic Metabolites in Human Plasma and Urine after Acute and Short-Term Daily Consumption of Mango Pulp |
| title_short | Pharmacokinetic Characterization of (Poly)phenolic Metabolites in Human Plasma and Urine after Acute and Short-Term Daily Consumption of Mango Pulp |
| title_sort | pharmacokinetic characterization of poly phenolic metabolites in human plasma and urine after acute and short term daily consumption of mango pulp |
| topic | mango polyphenols gallotannins pharmacokinetics plasma urine |
| url | https://www.mdpi.com/1420-3049/25/23/5522 |
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