Greater Durability and Protection against Herpes Simplex Viral Disease following Immunization of Mice with Single-Cycle ΔgD-2 Compared to an Adjuvanted Glycoprotein D Protein Vaccine

Greater Durability and Protection against Herpes Simplex Viral Disease following Immunization of Mice with Single-Cycle ΔgD-2 Compared to an Adjuvanted Glycoprotein D Protein Vaccine

Herpes simplex viruses (HSV) cause chronic infections with significant morbidity. Prior vaccines, designed to generate neutralizing antibodies (nAbs) targeting glycoprotein D (gD), failed to provide durable protection. We adopted a different strategy and evaluated a single-cycle virus deleted in gD...

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Bibliographic Details
Main Authors: Aakash Mahant Mahant, Matthew S. Gromisch, Leah Kravets, Clare Burn Aschner, Betsy C. Herold
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Vaccines
Subjects:
herpes simplex virus
vaccine durability
antibody-dependent cellular cytotoxicity
single-cycle DgD-2 vaccine
glycoprotein D subunit vaccine
Online Access:https://www.mdpi.com/2076-393X/11/8/1362

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