bHLH Transcription Factor Math6 Antagonizes TGF-β Signalling in Reprogramming, Pluripotency and Early Cell Fate Decisions

bHLH Transcription Factor Math6 Antagonizes TGF-β Signalling in Reprogramming, Pluripotency and Early Cell Fate Decisions

The basic helix-loop-helix (bHLH) transcription factor Math6 (Atonal homolog 8; Atoh8) plays a crucial role in a number of cellular processes during embryonic development, iron metabolism and tumorigenesis. We report here on its involvement in cellular reprogramming from fibroblasts to induced pluri...

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Bibliographic Details
Main Authors: Satya Srirama Karthik Divvela, Patrick Nell, Markus Napirei, Holm Zaehres, Jiayu Chen, Wanda Maria Gerding, Huu Phuc Nguyen, Shaorong Gao, Beate Brand-Saberi
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Cells
Subjects:
Atoh8
Math6
reprogramming
MET
primed state
pluripotency
mesendoderm
TGF beta
Online Access:https://www.mdpi.com/2073-4409/8/6/529

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