Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension
Implantable infusion pumps might improve the convenience and safety of intravenous treprostinil for pulmonary arterial hypertension. The LENUS Pro® pump (approved in Europe) has a fixed flow rate. Based on 126 pumps and 2853 refills, we retrospectively analyzed the actual flow rate from 09/2010 to 0...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-03-01
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| Series: | Pulmonary Circulation |
| Online Access: | https://doi.org/10.1177/2045894020910136 |
| _version_ | 1811327035010711552 |
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| author | Manuel J. Richter Satenik Harutyunova Tom Bollmann Simon Classen Jan Fuge Henning Gall Felix Gerhardt Hossein A. Ghofrani Hartmut Gunkel Ekkehard Grünig Michael Halank Alexander Heine Hans Klose Tobias J. Lange Claus Neurohr Kai Nickolaus Christian F. Opitz Stephan Rosenkranz Hans-Jürgen Seyfarth Khodr Tello Ralf Ewert Karen M. Olsson |
| author_facet | Manuel J. Richter Satenik Harutyunova Tom Bollmann Simon Classen Jan Fuge Henning Gall Felix Gerhardt Hossein A. Ghofrani Hartmut Gunkel Ekkehard Grünig Michael Halank Alexander Heine Hans Klose Tobias J. Lange Claus Neurohr Kai Nickolaus Christian F. Opitz Stephan Rosenkranz Hans-Jürgen Seyfarth Khodr Tello Ralf Ewert Karen M. Olsson |
| author_sort | Manuel J. Richter |
| collection | DOAJ |
| description | Implantable infusion pumps might improve the convenience and safety of intravenous treprostinil for pulmonary arterial hypertension. The LENUS Pro® pump (approved in Europe) has a fixed flow rate. Based on 126 pumps and 2853 refills, we retrospectively analyzed the actual flow rate from 09/2010 to 09/2018. A relevant flow rate variance is evident after three years; therefore, flow rate monitoring and dose adjustment are mandatory. |
| first_indexed | 2024-04-13T14:59:31Z |
| format | Article |
| id | doaj.art-e2a7a52eba0641e9a4c93c302a608334 |
| institution | Directory Open Access Journal |
| issn | 2045-8940 |
| language | English |
| last_indexed | 2024-04-13T14:59:31Z |
| publishDate | 2020-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Circulation |
| spelling | doaj.art-e2a7a52eba0641e9a4c93c302a6083342022-12-22T02:42:20ZengWileyPulmonary Circulation2045-89402020-03-011010.1177/2045894020910136Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertensionManuel J. Richter0Satenik Harutyunova1Tom Bollmann2Simon Classen3Jan Fuge4Henning Gall5Felix Gerhardt6Hossein A. Ghofrani7Hartmut Gunkel8Ekkehard Grünig9Michael Halank10Alexander Heine11Hans Klose12Tobias J. Lange13Claus Neurohr14Kai Nickolaus15Christian F. Opitz16Stephan Rosenkranz17Hans-Jürgen Seyfarth18Khodr Tello19Ralf Ewert20Karen M. Olsson21German Center for Lung Research (DZL), Giessen, GermanyCenter for Pulmonary Hypertension, Thorax Clinic at the University Hospital Heidelberg, Heidelberg, GermanyDepartment of Internal Medicine, Ernst-Moritz-Arndt University, Greifswald, GermanyDepartment of Vascular Surgery, Kerckhoff Heart, Rheuma and Thoracic Center, Bad Nauheim, GermanyDepartment of Respiratory Medicine, Hannover Medical School, Hannover, GermanyGerman Center for Lung Research (DZL), Giessen, GermanyDepartment III of Internal Medicine and Cologne Cardiovascular Research Center (CCRC), Cologne University Heart Center, Cologne, GermanyDepartment of Medicine, Imperial College London, London, UKpro-samed GmbH, Berlin, GermanyCenter for Pulmonary Hypertension, Thorax Clinic at the University Hospital Heidelberg, Heidelberg, GermanyDepartment of Internal Medicine I, University Hospital Carl Gustav Carus, Dresden, GermanyDepartment of Internal Medicine, Ernst-Moritz-Arndt University, Greifswald, GermanyDepartment of Pneumology, University of Hamburg, Hamburg, GermanyDepartment of Internal Medicine II, Division of Pneumology, University Medical Center Regensburg, Regensburg, GermanyDepartment for Pneumology and Respiratory Medicine, Robert-Bosch-Hospital, Gerlingen, GermanyDepartment of Pneumology, Kerckhoff Heart, Rheuma and Thoracic Center, Bad Nauheim, GermanyDepartment of Cardiology, DRK Kliniken Berlin, Berlin, GermanyDepartment III of Internal Medicine and Cologne Cardiovascular Research Center (CCRC), Cologne University Heart Center, Cologne, GermanyDepartment of Pneumology, University of Leipzig, Leipzig, GermanyGerman Center for Lung Research (DZL), Giessen, GermanyDepartment of Internal Medicine, Ernst-Moritz-Arndt University, Greifswald, GermanyDepartment of Respiratory Medicine, Hannover Medical School, Hannover, GermanyImplantable infusion pumps might improve the convenience and safety of intravenous treprostinil for pulmonary arterial hypertension. The LENUS Pro® pump (approved in Europe) has a fixed flow rate. Based on 126 pumps and 2853 refills, we retrospectively analyzed the actual flow rate from 09/2010 to 09/2018. A relevant flow rate variance is evident after three years; therefore, flow rate monitoring and dose adjustment are mandatory.https://doi.org/10.1177/2045894020910136 |
| spellingShingle | Manuel J. Richter Satenik Harutyunova Tom Bollmann Simon Classen Jan Fuge Henning Gall Felix Gerhardt Hossein A. Ghofrani Hartmut Gunkel Ekkehard Grünig Michael Halank Alexander Heine Hans Klose Tobias J. Lange Claus Neurohr Kai Nickolaus Christian F. Opitz Stephan Rosenkranz Hans-Jürgen Seyfarth Khodr Tello Ralf Ewert Karen M. Olsson Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension Pulmonary Circulation |
| title | Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension |
| title_full | Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension |
| title_fullStr | Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension |
| title_full_unstemmed | Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension |
| title_short | Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension |
| title_sort | flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension |
| url | https://doi.org/10.1177/2045894020910136 |
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