Inhibition of IL-1 Signaling by Antisense Oligonucleotide-mediated Exon Skipping of IL-1 Receptor Accessory Protein (IL-1RAcP)

Inhibition of IL-1 Signaling by Antisense Oligonucleotide-mediated Exon Skipping of IL-1 Receptor Accessory Protein (IL-1RAcP)

The cytokine interleukin 1(IL-1) initiates a wide range of proinflammatory cascades and its inhibition has been shown to decrease inflammation in a variety of diseases. IL-1 receptor accessory protein (IL-1RAcP) is an indispensible part of the IL-1R complex that stabilizes IL-1/IL-1R interaction and...

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Bibliographic Details
Main Authors: A Seda Yılmaz-Eliş, Annemieke Aartsma-Rus, Peter AC 't Hoen, Huma Safdar, Cor Breukel, Bart JM van Vlijmen, Judith van Deutekom, Sjef de Kimpe, Gert-Jan van Ommen, J Sjef Verbeek
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
antisense oligonucleotide
exon skipping
inflammation
interleukin 1
soluble IL-1R accessory protein
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301263

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