Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone

Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone

Abstract Background Both loss- and gain-of-function of Wnt/β-catenin signaling in chondrocytes result in exacerbation of osteoarthritis (OA). Here, we examined the activity and roles of Wnt/β-catenin signaling in the superficial zone (SFZ) of articular cartilage. Methods Wnt/β-catenin signaling acti...

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Main Authors: Fengjun Xuan, Fumiko Yano, Daisuke Mori, Ryota Chijimatsu, Yuji Maenohara, Hideki Nakamoto, Yoshifumi Mori, Yuma Makii, Takeshi Oichi, Makoto Mark Taketo, Hironori Hojo, Shinsuke Ohba, Ung-il Chung, Sakae Tanaka, Taku Saito
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Arthritis Research & Therapy
Subjects:
Osteoarthritis
Chondrocyte
Superficial zone
Wnt signaling
Online Access:http://link.springer.com/article/10.1186/s13075-019-2041-5

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