Pseudoviruses, a safer toolbox for vaccine development against enveloped viruses
ABSTRACTIntroduction Pseudoviruses are recombinant, replication-incompetent, viral particles designed to mimic the surface characteristics of native enveloped viruses. They are a safer, and cost-effective research alternative to live viruses. With the potential emergence of the next major infectious...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Expert Review of Vaccines |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/14760584.2023.2299380 |
| _version_ | 1797367573677867008 |
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| author | Syamala R. Thimmiraju Jason T. Kimata Jeroen Pollet |
| author_facet | Syamala R. Thimmiraju Jason T. Kimata Jeroen Pollet |
| author_sort | Syamala R. Thimmiraju |
| collection | DOAJ |
| description | ABSTRACTIntroduction Pseudoviruses are recombinant, replication-incompetent, viral particles designed to mimic the surface characteristics of native enveloped viruses. They are a safer, and cost-effective research alternative to live viruses. With the potential emergence of the next major infectious disease, more vaccine scientists must become familiar with the pseudovirus platform as a vaccine development tool to mitigate future outbreaks.Areas Covered This review aims at vaccine developers to provide a basic understanding of pseudoviruses, list their production methods, and discuss their utility to assess vaccine efficacy against enveloped viral pathogens. We further illustrate their usefulness as wet-lab simulators for emerging mutant variants, and new viruses to help prepare for current and future viral outbreaks, minimizing the need for gain-of-function experiments with highly infectious or lethal enveloped viruses.Expert opinion With this platform, researchers can better understand the role of virus–receptor interactions and entry in infections, prepare for dangerous mutations, and develop effective vaccines. |
| first_indexed | 2024-03-08T17:19:18Z |
| format | Article |
| id | doaj.art-e2ab898358f44369bbe76947ec020885 |
| institution | Directory Open Access Journal |
| issn | 1476-0584 1744-8395 |
| language | English |
| last_indexed | 2024-03-08T17:19:18Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Expert Review of Vaccines |
| spelling | doaj.art-e2ab898358f44369bbe76947ec0208852024-01-03T08:31:12ZengTaylor & Francis GroupExpert Review of Vaccines1476-05841744-83952024-12-0123117418510.1080/14760584.2023.2299380Pseudoviruses, a safer toolbox for vaccine development against enveloped virusesSyamala R. Thimmiraju0Jason T. Kimata1Jeroen Pollet2Department of Pediatrics, Section of Tropical Medicine, Baylor College of Medicine, Houston, TX, USADepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, USADepartment of Pediatrics, Section of Tropical Medicine, Baylor College of Medicine, Houston, TX, USAABSTRACTIntroduction Pseudoviruses are recombinant, replication-incompetent, viral particles designed to mimic the surface characteristics of native enveloped viruses. They are a safer, and cost-effective research alternative to live viruses. With the potential emergence of the next major infectious disease, more vaccine scientists must become familiar with the pseudovirus platform as a vaccine development tool to mitigate future outbreaks.Areas Covered This review aims at vaccine developers to provide a basic understanding of pseudoviruses, list their production methods, and discuss their utility to assess vaccine efficacy against enveloped viral pathogens. We further illustrate their usefulness as wet-lab simulators for emerging mutant variants, and new viruses to help prepare for current and future viral outbreaks, minimizing the need for gain-of-function experiments with highly infectious or lethal enveloped viruses.Expert opinion With this platform, researchers can better understand the role of virus–receptor interactions and entry in infections, prepare for dangerous mutations, and develop effective vaccines.https://www.tandfonline.com/doi/10.1080/14760584.2023.2299380Pseudovirusenveloped virusesvaccine developmentneutralizing antibodiesbiosafe |
| spellingShingle | Syamala R. Thimmiraju Jason T. Kimata Jeroen Pollet Pseudoviruses, a safer toolbox for vaccine development against enveloped viruses Expert Review of Vaccines Pseudovirus enveloped viruses vaccine development neutralizing antibodies biosafe |
| title | Pseudoviruses, a safer toolbox for vaccine development against enveloped viruses |
| title_full | Pseudoviruses, a safer toolbox for vaccine development against enveloped viruses |
| title_fullStr | Pseudoviruses, a safer toolbox for vaccine development against enveloped viruses |
| title_full_unstemmed | Pseudoviruses, a safer toolbox for vaccine development against enveloped viruses |
| title_short | Pseudoviruses, a safer toolbox for vaccine development against enveloped viruses |
| title_sort | pseudoviruses a safer toolbox for vaccine development against enveloped viruses |
| topic | Pseudovirus enveloped viruses vaccine development neutralizing antibodies biosafe |
| url | https://www.tandfonline.com/doi/10.1080/14760584.2023.2299380 |
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