The Differential Effect of Excess Aldosterone on Skeletal Muscle Mass by Sex
The effects of excess aldosterone on skeletal muscle in individuals with primary aldosteronism (PA) are unknown. To examine the effects of aldosterone on skeletal muscle mass in patients with PA, by sex, 309 consecutive patients were enrolled. Skeletal muscle and fat mass of 62 patients with PA were...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2019.00195/full |
| _version_ | 1819237621846507520 |
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| author | Mi Kyung Kwak Mi Kyung Kwak Seung-Eun Lee Yoon Young Cho Sunghwan Suh Beom-Jun Kim Kee-Ho Song Jung-Min Koh Jae Hyeon Kim Seung Hun Lee |
| author_facet | Mi Kyung Kwak Mi Kyung Kwak Seung-Eun Lee Yoon Young Cho Sunghwan Suh Beom-Jun Kim Kee-Ho Song Jung-Min Koh Jae Hyeon Kim Seung Hun Lee |
| author_sort | Mi Kyung Kwak |
| collection | DOAJ |
| description | The effects of excess aldosterone on skeletal muscle in individuals with primary aldosteronism (PA) are unknown. To examine the effects of aldosterone on skeletal muscle mass in patients with PA, by sex, 309 consecutive patients were enrolled. Skeletal muscle and fat mass of 62 patients with PA were compared with those of 247 controls with non-functioning adrenal incidentaloma (NFAI). Body composition parameters were measured using bioelectrical impedance analysis, and plasma aldosterone concentration (PAC) was measured using radioimmunoassay. The PAC in all women, but not in men, showed an inverse association with both appendicular skeletal muscle mass (ASM) (β = −0.197, P = 0.016) and height-adjusted ASM (HA-ASM) (β = −0.207, P = 0.009). HA-ASM in women (but not in men) with PA was 5.0% lower than that in women with NFAI (P = 0.036). Furthermore, women with PA had a lower HA-ASM than 1:1 age- and sex-matched controls with NFAI by 5.7% (P = 0.049) and tended to have a lower HA-ASM than 1:3 age-, sex-, and menopausal status-matched controls without adrenal incidentaloma (AI) by 7.3% (P = 0.053). The odds ratio (OR), per quartile increase in PAC, of low HA-ASM in women was 1.18 [95% confidence interval (CI), 1.01–1.39; P = 0.035]. The odds of HA-ASM in subjects with PA were 10.63-fold (95% CI: 0.83–135.50) higher, with marginal significance (P = 0.069) than in those with NFAI. Skeletal muscle mass in women with PA was lower than that in women with NFAI; suggesting that excess aldosterone has adverse effects on skeletal muscle metabolism. |
| first_indexed | 2024-12-23T13:23:15Z |
| format | Article |
| id | doaj.art-e2ada22632204ddfacb62e27b7c83cc6 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-23T13:23:15Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-e2ada22632204ddfacb62e27b7c83cc62022-12-21T17:45:24ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922019-03-011010.3389/fendo.2019.00195437163The Differential Effect of Excess Aldosterone on Skeletal Muscle Mass by SexMi Kyung Kwak0Mi Kyung Kwak1Seung-Eun Lee2Yoon Young Cho3Sunghwan Suh4Beom-Jun Kim5Kee-Ho Song6Jung-Min Koh7Jae Hyeon Kim8Seung Hun Lee9Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Hallym University Dontan Sacred Heart Hospital, Hwaseong-Si, South KoreaDivision of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDivision of Endocrinology and Metabolism, Department of Medicine, Gyeongsang National University School of Medicine, Jinju, South KoreaDivision of Endocrinology and Metabolism, Department of Internal Medicine, Dong-A University Medical Center, Dong-A University College of Medicine, Busan, South KoreaDivision of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaDivision of Endocrinology and Metabolism, Konkuk University School of Medicine, Konkuk University Medical Center, Seoul, South KoreaDivision of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaDivision of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South KoreaDivision of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South KoreaThe effects of excess aldosterone on skeletal muscle in individuals with primary aldosteronism (PA) are unknown. To examine the effects of aldosterone on skeletal muscle mass in patients with PA, by sex, 309 consecutive patients were enrolled. Skeletal muscle and fat mass of 62 patients with PA were compared with those of 247 controls with non-functioning adrenal incidentaloma (NFAI). Body composition parameters were measured using bioelectrical impedance analysis, and plasma aldosterone concentration (PAC) was measured using radioimmunoassay. The PAC in all women, but not in men, showed an inverse association with both appendicular skeletal muscle mass (ASM) (β = −0.197, P = 0.016) and height-adjusted ASM (HA-ASM) (β = −0.207, P = 0.009). HA-ASM in women (but not in men) with PA was 5.0% lower than that in women with NFAI (P = 0.036). Furthermore, women with PA had a lower HA-ASM than 1:1 age- and sex-matched controls with NFAI by 5.7% (P = 0.049) and tended to have a lower HA-ASM than 1:3 age-, sex-, and menopausal status-matched controls without adrenal incidentaloma (AI) by 7.3% (P = 0.053). The odds ratio (OR), per quartile increase in PAC, of low HA-ASM in women was 1.18 [95% confidence interval (CI), 1.01–1.39; P = 0.035]. The odds of HA-ASM in subjects with PA were 10.63-fold (95% CI: 0.83–135.50) higher, with marginal significance (P = 0.069) than in those with NFAI. Skeletal muscle mass in women with PA was lower than that in women with NFAI; suggesting that excess aldosterone has adverse effects on skeletal muscle metabolism.https://www.frontiersin.org/article/10.3389/fendo.2019.00195/fullprimary aldosteronismaldosteroneskeletal muscle masssarcopeniasex |
| spellingShingle | Mi Kyung Kwak Mi Kyung Kwak Seung-Eun Lee Yoon Young Cho Sunghwan Suh Beom-Jun Kim Kee-Ho Song Jung-Min Koh Jae Hyeon Kim Seung Hun Lee The Differential Effect of Excess Aldosterone on Skeletal Muscle Mass by Sex Frontiers in Endocrinology primary aldosteronism aldosterone skeletal muscle mass sarcopenia sex |
| title | The Differential Effect of Excess Aldosterone on Skeletal Muscle Mass by Sex |
| title_full | The Differential Effect of Excess Aldosterone on Skeletal Muscle Mass by Sex |
| title_fullStr | The Differential Effect of Excess Aldosterone on Skeletal Muscle Mass by Sex |
| title_full_unstemmed | The Differential Effect of Excess Aldosterone on Skeletal Muscle Mass by Sex |
| title_short | The Differential Effect of Excess Aldosterone on Skeletal Muscle Mass by Sex |
| title_sort | differential effect of excess aldosterone on skeletal muscle mass by sex |
| topic | primary aldosteronism aldosterone skeletal muscle mass sarcopenia sex |
| url | https://www.frontiersin.org/article/10.3389/fendo.2019.00195/full |
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