MFS transporters required for multidrug/multixenobiotic (MD/MX) resistance in the model yeast: understanding their physiological function through post-genomic approaches
Multidrug/Multixenobiotic resistance (MDR/MXR) is a widespread phenomenon with clinical, agricultural and biotechnological implications, where MDR/MXR transporters that are presumably able to catalyze the efflux of multiple cytotoxic compounds play a key role in the acquisition of resistance. Howeve...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-05-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00180/full |
| _version_ | 1828515015268761600 |
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| author | Sandra C. dos Santos Miguel Cacho Teixeira Paulo J. Dias Isabel eSá-Correia |
| author_facet | Sandra C. dos Santos Miguel Cacho Teixeira Paulo J. Dias Isabel eSá-Correia |
| author_sort | Sandra C. dos Santos |
| collection | DOAJ |
| description | Multidrug/Multixenobiotic resistance (MDR/MXR) is a widespread phenomenon with clinical, agricultural and biotechnological implications, where MDR/MXR transporters that are presumably able to catalyze the efflux of multiple cytotoxic compounds play a key role in the acquisition of resistance. However, although these proteins have been traditionally considered drug exporters, the physiological function of MDR/MXR transporters and the exact mechanism of their involvement in resistance to cytotoxic compounds are still open to debate. In fact, the wide range of structurally and functionally unrelated substrates that these transporters are presumably able to export has puzzled researchers for years. The discussion has now shifted towards the possibility of at least some MDR/MXR transporters exerting their effect as the result of a natural physiological role in the cell, rather than through the direct export of cytotoxic compounds, and the hypothesis that MDR/MXR transporters may have evolved in nature for other purposes than conferring chemoprotection has been gaining momentum in recent years. This review focuses on the drug transporters of the Major Facilitator Superfamily (MFS; drug:H+ antiporters) in the model yeast Saccharomyces cerevisiae. New insights into the natural roles of these transporters are described and discussed here, focusing on the knowledge obtained or suggested by post-genomic research. The new information reviewed here provides clues into the unexpectedly complex roles of these transporters, including a proposed indirect regulation of the stress response machinery and control of membrane potential and/or internal pH, with a special emphasis on a genome-wide view of the regulation and evolution of MDR/MXR-MFS transporters. |
| first_indexed | 2024-12-11T18:07:36Z |
| format | Article |
| id | doaj.art-e2ae4f08decf4994b7657a17f7c2df54 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-11T18:07:36Z |
| publishDate | 2014-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-e2ae4f08decf4994b7657a17f7c2df542022-12-22T00:55:40ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2014-05-01510.3389/fphys.2014.0018092315MFS transporters required for multidrug/multixenobiotic (MD/MX) resistance in the model yeast: understanding their physiological function through post-genomic approachesSandra C. dos Santos0Miguel Cacho Teixeira1Paulo J. Dias2Isabel eSá-Correia3Instituto Superior TécnicoInstituto Superior TécnicoInstituto Superior TécnicoInstituto Superior TécnicoMultidrug/Multixenobiotic resistance (MDR/MXR) is a widespread phenomenon with clinical, agricultural and biotechnological implications, where MDR/MXR transporters that are presumably able to catalyze the efflux of multiple cytotoxic compounds play a key role in the acquisition of resistance. However, although these proteins have been traditionally considered drug exporters, the physiological function of MDR/MXR transporters and the exact mechanism of their involvement in resistance to cytotoxic compounds are still open to debate. In fact, the wide range of structurally and functionally unrelated substrates that these transporters are presumably able to export has puzzled researchers for years. The discussion has now shifted towards the possibility of at least some MDR/MXR transporters exerting their effect as the result of a natural physiological role in the cell, rather than through the direct export of cytotoxic compounds, and the hypothesis that MDR/MXR transporters may have evolved in nature for other purposes than conferring chemoprotection has been gaining momentum in recent years. This review focuses on the drug transporters of the Major Facilitator Superfamily (MFS; drug:H+ antiporters) in the model yeast Saccharomyces cerevisiae. New insights into the natural roles of these transporters are described and discussed here, focusing on the knowledge obtained or suggested by post-genomic research. The new information reviewed here provides clues into the unexpectedly complex roles of these transporters, including a proposed indirect regulation of the stress response machinery and control of membrane potential and/or internal pH, with a special emphasis on a genome-wide view of the regulation and evolution of MDR/MXR-MFS transporters.http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00180/fullSaccharomyces cerevisiaeTranscriptional regulationphylogenetic analysisgenome-wide approachesMultidrug/Multixenobiotic resistance (MDR/MXR)MDR/MXR transporters |
| spellingShingle | Sandra C. dos Santos Miguel Cacho Teixeira Paulo J. Dias Isabel eSá-Correia MFS transporters required for multidrug/multixenobiotic (MD/MX) resistance in the model yeast: understanding their physiological function through post-genomic approaches Frontiers in Physiology Saccharomyces cerevisiae Transcriptional regulation phylogenetic analysis genome-wide approaches Multidrug/Multixenobiotic resistance (MDR/MXR) MDR/MXR transporters |
| title | MFS transporters required for multidrug/multixenobiotic (MD/MX) resistance in the model yeast: understanding their physiological function through post-genomic approaches |
| title_full | MFS transporters required for multidrug/multixenobiotic (MD/MX) resistance in the model yeast: understanding their physiological function through post-genomic approaches |
| title_fullStr | MFS transporters required for multidrug/multixenobiotic (MD/MX) resistance in the model yeast: understanding their physiological function through post-genomic approaches |
| title_full_unstemmed | MFS transporters required for multidrug/multixenobiotic (MD/MX) resistance in the model yeast: understanding their physiological function through post-genomic approaches |
| title_short | MFS transporters required for multidrug/multixenobiotic (MD/MX) resistance in the model yeast: understanding their physiological function through post-genomic approaches |
| title_sort | mfs transporters required for multidrug multixenobiotic md mx resistance in the model yeast understanding their physiological function through post genomic approaches |
| topic | Saccharomyces cerevisiae Transcriptional regulation phylogenetic analysis genome-wide approaches Multidrug/Multixenobiotic resistance (MDR/MXR) MDR/MXR transporters |
| url | http://journal.frontiersin.org/Journal/10.3389/fphys.2014.00180/full |
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