Identifying Thyroid Carcinoma-Related Genes by Integrating GWAS and eQTL Data
Thyroid carcinoma (TC) is the most common endocrine malignancy. The incidence rate of thyroid cancer has increased rapidly in recent years. The occurrence and development of thyroid cancers are highly related to the massive genetic and epigenetic changes. Therefore, it is essential to explore the me...
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| Format: | Article |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.645275/full |
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| author | Fei Shen Fei Shen Xiaoxiong Gan Xiaoxiong Gan Ruiying Zhong Jianhua Feng Jianhua Feng Zhen Chen Zhen Chen Mengli Guo Mengli Guo Yayi Li Yayi Li Zhaofeng Wu Wensong Cai Wensong Cai Bo Xu Bo Xu |
| author_facet | Fei Shen Fei Shen Xiaoxiong Gan Xiaoxiong Gan Ruiying Zhong Jianhua Feng Jianhua Feng Zhen Chen Zhen Chen Mengli Guo Mengli Guo Yayi Li Yayi Li Zhaofeng Wu Wensong Cai Wensong Cai Bo Xu Bo Xu |
| author_sort | Fei Shen |
| collection | DOAJ |
| description | Thyroid carcinoma (TC) is the most common endocrine malignancy. The incidence rate of thyroid cancer has increased rapidly in recent years. The occurrence and development of thyroid cancers are highly related to the massive genetic and epigenetic changes. Therefore, it is essential to explore the mechanism of thyroid cancer pathogenesis. Genome-Wide Association Studies (GWAS) have been widely used in various diseases. Researchers have found multiple single nucleotide polymorphisms (SNPs) are significantly related to TC. However, the biological mechanism of these SNPs is still unknown. In this paper, we used one GWAS dataset and two eQTL datasets, and integrated GWAS with expression quantitative trait loci (eQTL) in both thyroid and blood to explore the mechanism of mutations and causal genes of thyroid cancer. Finally, we found rs1912998 regulates the expression of IGFALS (P = 1.70E-06) and HAGH (P = 5.08E-07) in thyroid, which is significantly related to thyroid cancer. In addition, KEGG shows that these genes participate in multiple thyroid cancer-related pathways. |
| first_indexed | 2024-12-17T05:30:47Z |
| format | Article |
| id | doaj.art-e2af6269309541bc8eb152657a20f682 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-17T05:30:47Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-e2af6269309541bc8eb152657a20f6822022-12-21T22:01:44ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-02-01910.3389/fcell.2021.645275645275Identifying Thyroid Carcinoma-Related Genes by Integrating GWAS and eQTL DataFei Shen0Fei Shen1Xiaoxiong Gan2Xiaoxiong Gan3Ruiying Zhong4Jianhua Feng5Jianhua Feng6Zhen Chen7Zhen Chen8Mengli Guo9Mengli Guo10Yayi Li11Yayi Li12Zhaofeng Wu13Wensong Cai14Wensong Cai15Bo Xu16Bo Xu17Department of Thyroid Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, ChinaDepartment of Thyroid Surgery, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Thyroid Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, ChinaDepartment of Thyroid Surgery, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Hepatobiliary, Pancreatic and Splenic Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, ChinaDepartment of Thyroid Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, ChinaDepartment of Thyroid Surgery, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Thyroid Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, ChinaDepartment of Thyroid Surgery, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Thyroid Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, ChinaDepartment of Thyroid Surgery, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Thyroid Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, ChinaDepartment of Thyroid Surgery, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Hepatobiliary, Pancreatic and Splenic Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, ChinaDepartment of Thyroid Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, ChinaDepartment of Thyroid Surgery, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, ChinaDepartment of Thyroid Surgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, ChinaDepartment of Thyroid Surgery, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou, ChinaThyroid carcinoma (TC) is the most common endocrine malignancy. The incidence rate of thyroid cancer has increased rapidly in recent years. The occurrence and development of thyroid cancers are highly related to the massive genetic and epigenetic changes. Therefore, it is essential to explore the mechanism of thyroid cancer pathogenesis. Genome-Wide Association Studies (GWAS) have been widely used in various diseases. Researchers have found multiple single nucleotide polymorphisms (SNPs) are significantly related to TC. However, the biological mechanism of these SNPs is still unknown. In this paper, we used one GWAS dataset and two eQTL datasets, and integrated GWAS with expression quantitative trait loci (eQTL) in both thyroid and blood to explore the mechanism of mutations and causal genes of thyroid cancer. Finally, we found rs1912998 regulates the expression of IGFALS (P = 1.70E-06) and HAGH (P = 5.08E-07) in thyroid, which is significantly related to thyroid cancer. In addition, KEGG shows that these genes participate in multiple thyroid cancer-related pathways.https://www.frontiersin.org/articles/10.3389/fcell.2021.645275/fullthyroid carcinomars1912998IGFALSHAGHGWASeQTL |
| spellingShingle | Fei Shen Fei Shen Xiaoxiong Gan Xiaoxiong Gan Ruiying Zhong Jianhua Feng Jianhua Feng Zhen Chen Zhen Chen Mengli Guo Mengli Guo Yayi Li Yayi Li Zhaofeng Wu Wensong Cai Wensong Cai Bo Xu Bo Xu Identifying Thyroid Carcinoma-Related Genes by Integrating GWAS and eQTL Data Frontiers in Cell and Developmental Biology thyroid carcinoma rs1912998 IGFALS HAGH GWAS eQTL |
| title | Identifying Thyroid Carcinoma-Related Genes by Integrating GWAS and eQTL Data |
| title_full | Identifying Thyroid Carcinoma-Related Genes by Integrating GWAS and eQTL Data |
| title_fullStr | Identifying Thyroid Carcinoma-Related Genes by Integrating GWAS and eQTL Data |
| title_full_unstemmed | Identifying Thyroid Carcinoma-Related Genes by Integrating GWAS and eQTL Data |
| title_short | Identifying Thyroid Carcinoma-Related Genes by Integrating GWAS and eQTL Data |
| title_sort | identifying thyroid carcinoma related genes by integrating gwas and eqtl data |
| topic | thyroid carcinoma rs1912998 IGFALS HAGH GWAS eQTL |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.645275/full |
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