Bisoprolol transdermal patch improves orthostatic hypotension in patients with chronic heart failure and hypertension
β blockers (BBs) play an important role in heart failure (HF) treatment. However, orthostatic hypotension (OH) is sometimes caused by BBs. The bisoprolol transdermal patch works more slowly and is long acting compared with the bisoprolol fumarate tablet. The risk of OH may be reduced by using the bi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-08-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2020.1723616 |
| _version_ | 1797681337735315456 |
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| author | Shunsuke Kiuchi Shinji Hisatake Takayuki Kabuki Takashi Oka Shintaro Dobashi Takahiro Fujii Takahide Sano Takanori Ikeda |
| author_facet | Shunsuke Kiuchi Shinji Hisatake Takayuki Kabuki Takashi Oka Shintaro Dobashi Takahiro Fujii Takahide Sano Takanori Ikeda |
| author_sort | Shunsuke Kiuchi |
| collection | DOAJ |
| description | β blockers (BBs) play an important role in heart failure (HF) treatment. However, orthostatic hypotension (OH) is sometimes caused by BBs. The bisoprolol transdermal patch works more slowly and is long acting compared with the bisoprolol fumarate tablet. The risk of OH may be reduced by using the bisoprolol transdermal patch. We evaluated 57 consecutive patients who were taking the bisoprolol fumarate tablet for chronic HF with hypertension from November 2016 to September 2017. We switched the patients to the bisoprolol transdermal patch. Because 12 of 57 subjects could not continue using the bisoprolol transdermal patch, we analyzed the remaining 45 patients. We investigated BP, blood tests, and changes in BP from supine to standing positions before and after 6 months of switching from tablet to patch. OH was diagnosed by observing a systolic/diastolic BP drop of at least 20/10 mmHg or an absolute systolic BP (sBP) of <90 mmHg from the standing position. No significant changes were observed in the BP and BPs from supine to standing positions, whereas log brain natriuretic peptide was significantly reduced after switching from patch to tablet (2.102 to 2.070pg/dl, P = .039). OH, which occurred in originally 17 patients, showed improvement and eventually appeared in 4 patients. In these patients, changes in BP from supine to standing positions were also significantly improved (changes in sBP, −11 to −6mmHg, P = .016). This study demonstrated that switching from the bisoprolol fumarate tablet to transdermal patch reduced the morbidity of OH in HF patients. |
| first_indexed | 2024-03-11T23:43:25Z |
| format | Article |
| id | doaj.art-e2b13811e31941fdbebed77d080c2fcc |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:43:25Z |
| publishDate | 2020-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-e2b13811e31941fdbebed77d080c2fcc2023-09-19T15:19:28ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062020-08-0142653954410.1080/10641963.2020.17236161723616Bisoprolol transdermal patch improves orthostatic hypotension in patients with chronic heart failure and hypertensionShunsuke Kiuchi0Shinji Hisatake1Takayuki Kabuki2Takashi Oka3Shintaro Dobashi4Takahiro Fujii5Takahide Sano6Takanori Ikeda7Toho University Graduate School of MedicineToho University Graduate School of MedicineToho University Graduate School of MedicineToho University Graduate School of MedicineToho University Graduate School of MedicineToho University Graduate School of MedicineToho University Graduate School of MedicineToho University Graduate School of Medicineβ blockers (BBs) play an important role in heart failure (HF) treatment. However, orthostatic hypotension (OH) is sometimes caused by BBs. The bisoprolol transdermal patch works more slowly and is long acting compared with the bisoprolol fumarate tablet. The risk of OH may be reduced by using the bisoprolol transdermal patch. We evaluated 57 consecutive patients who were taking the bisoprolol fumarate tablet for chronic HF with hypertension from November 2016 to September 2017. We switched the patients to the bisoprolol transdermal patch. Because 12 of 57 subjects could not continue using the bisoprolol transdermal patch, we analyzed the remaining 45 patients. We investigated BP, blood tests, and changes in BP from supine to standing positions before and after 6 months of switching from tablet to patch. OH was diagnosed by observing a systolic/diastolic BP drop of at least 20/10 mmHg or an absolute systolic BP (sBP) of <90 mmHg from the standing position. No significant changes were observed in the BP and BPs from supine to standing positions, whereas log brain natriuretic peptide was significantly reduced after switching from patch to tablet (2.102 to 2.070pg/dl, P = .039). OH, which occurred in originally 17 patients, showed improvement and eventually appeared in 4 patients. In these patients, changes in BP from supine to standing positions were also significantly improved (changes in sBP, −11 to −6mmHg, P = .016). This study demonstrated that switching from the bisoprolol fumarate tablet to transdermal patch reduced the morbidity of OH in HF patients.http://dx.doi.org/10.1080/10641963.2020.1723616bisoprolol transdermal patchbisoprolol fumarate tabletchronic heart failureblood pressure variabilityorthostatic hypotension |
| spellingShingle | Shunsuke Kiuchi Shinji Hisatake Takayuki Kabuki Takashi Oka Shintaro Dobashi Takahiro Fujii Takahide Sano Takanori Ikeda Bisoprolol transdermal patch improves orthostatic hypotension in patients with chronic heart failure and hypertension Clinical and Experimental Hypertension bisoprolol transdermal patch bisoprolol fumarate tablet chronic heart failure blood pressure variability orthostatic hypotension |
| title | Bisoprolol transdermal patch improves orthostatic hypotension in patients with chronic heart failure and hypertension |
| title_full | Bisoprolol transdermal patch improves orthostatic hypotension in patients with chronic heart failure and hypertension |
| title_fullStr | Bisoprolol transdermal patch improves orthostatic hypotension in patients with chronic heart failure and hypertension |
| title_full_unstemmed | Bisoprolol transdermal patch improves orthostatic hypotension in patients with chronic heart failure and hypertension |
| title_short | Bisoprolol transdermal patch improves orthostatic hypotension in patients with chronic heart failure and hypertension |
| title_sort | bisoprolol transdermal patch improves orthostatic hypotension in patients with chronic heart failure and hypertension |
| topic | bisoprolol transdermal patch bisoprolol fumarate tablet chronic heart failure blood pressure variability orthostatic hypotension |
| url | http://dx.doi.org/10.1080/10641963.2020.1723616 |
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