Nanoparticles to Improve the Efficacy of Peptide-Based Cancer Vaccines
Nanoparticles represent a potent antigen presentation and delivery system to elicit an optimal immune response by effector cells targeting tumor-associated antigens expressed by cancer cells. Many types of nanoparticles have been developed, such as polymeric complexes, liposomes, micelles and protei...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/4/1049 |
| _version_ | 1797569813142306816 |
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| author | Anna Lucia Tornesello Maria Tagliamonte Maria Lina Tornesello Franco M. Buonaguro Luigi Buonaguro |
| author_facet | Anna Lucia Tornesello Maria Tagliamonte Maria Lina Tornesello Franco M. Buonaguro Luigi Buonaguro |
| author_sort | Anna Lucia Tornesello |
| collection | DOAJ |
| description | Nanoparticles represent a potent antigen presentation and delivery system to elicit an optimal immune response by effector cells targeting tumor-associated antigens expressed by cancer cells. Many types of nanoparticles have been developed, such as polymeric complexes, liposomes, micelles and protein-based structures such as virus like particles. All of them show promising results for immunotherapy approaches. In particular, the immunogenicity of peptide-based cancer vaccines can be significantly potentiated by nanoparticles. Indeed, nanoparticles are able to enhance the targeting of antigen-presenting cells (APCs) and trigger cytokine production for optimal T cell response. The present review summarizes the categories of nanoparticles and peptide cancer vaccines which are currently under pre-clinical evaluation. |
| first_indexed | 2024-03-10T20:16:52Z |
| format | Article |
| id | doaj.art-e2b227861d60497fb140fcd9de851c46 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T20:16:52Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-e2b227861d60497fb140fcd9de851c462023-11-19T22:32:16ZengMDPI AGCancers2072-66942020-04-01124104910.3390/cancers12041049Nanoparticles to Improve the Efficacy of Peptide-Based Cancer VaccinesAnna Lucia Tornesello0Maria Tagliamonte1Maria Lina Tornesello2Franco M. Buonaguro3Luigi Buonaguro4Molecular Biology and Viral Oncology Unit, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, via Mariano Semmola, 80131 Napoli, ItalyInnovative Immunological Models, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, via Mariano Semmola, 80131 Napoli, ItalyMolecular Biology and Viral Oncology Unit, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, via Mariano Semmola, 80131 Napoli, ItalyMolecular Biology and Viral Oncology Unit, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, via Mariano Semmola, 80131 Napoli, ItalyInnovative Immunological Models, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, via Mariano Semmola, 80131 Napoli, ItalyNanoparticles represent a potent antigen presentation and delivery system to elicit an optimal immune response by effector cells targeting tumor-associated antigens expressed by cancer cells. Many types of nanoparticles have been developed, such as polymeric complexes, liposomes, micelles and protein-based structures such as virus like particles. All of them show promising results for immunotherapy approaches. In particular, the immunogenicity of peptide-based cancer vaccines can be significantly potentiated by nanoparticles. Indeed, nanoparticles are able to enhance the targeting of antigen-presenting cells (APCs) and trigger cytokine production for optimal T cell response. The present review summarizes the categories of nanoparticles and peptide cancer vaccines which are currently under pre-clinical evaluation.https://www.mdpi.com/2072-6694/12/4/1049cancer vaccinespeptide-based vaccinenanoparticlestumor vaccinesCPPsVLPs |
| spellingShingle | Anna Lucia Tornesello Maria Tagliamonte Maria Lina Tornesello Franco M. Buonaguro Luigi Buonaguro Nanoparticles to Improve the Efficacy of Peptide-Based Cancer Vaccines Cancers cancer vaccines peptide-based vaccine nanoparticles tumor vaccines CPPs VLPs |
| title | Nanoparticles to Improve the Efficacy of Peptide-Based Cancer Vaccines |
| title_full | Nanoparticles to Improve the Efficacy of Peptide-Based Cancer Vaccines |
| title_fullStr | Nanoparticles to Improve the Efficacy of Peptide-Based Cancer Vaccines |
| title_full_unstemmed | Nanoparticles to Improve the Efficacy of Peptide-Based Cancer Vaccines |
| title_short | Nanoparticles to Improve the Efficacy of Peptide-Based Cancer Vaccines |
| title_sort | nanoparticles to improve the efficacy of peptide based cancer vaccines |
| topic | cancer vaccines peptide-based vaccine nanoparticles tumor vaccines CPPs VLPs |
| url | https://www.mdpi.com/2072-6694/12/4/1049 |
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