Bioinformatic network analysis on the molecular interactions between Parkinson’s disease, alpha-synuclein, and infertility condition
Abstract Background Parkinson’s disease (PD) is a neurodegenerative condition that is characterized by a progressive decline of neural pathways, and its pathology is associated with alpha-synuclein abnormalities. Currently, infertility affects about 10% of individuals of fertile age within the USA....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2023-09-01
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| Series: | Middle East Fertility Society Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43043-023-00148-4 |
| _version_ | 1797453843864223744 |
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| author | Velu Krishnan Shivani S. Patel Priyanka Shenoy Jessica Cottrell |
| author_facet | Velu Krishnan Shivani S. Patel Priyanka Shenoy Jessica Cottrell |
| author_sort | Velu Krishnan |
| collection | DOAJ |
| description | Abstract Background Parkinson’s disease (PD) is a neurodegenerative condition that is characterized by a progressive decline of neural pathways, and its pathology is associated with alpha-synuclein abnormalities. Currently, infertility affects about 10% of individuals of fertile age within the USA. Interestingly, an increased length of fertility is associated with a decreased incidence of PD. Our study utilized QIAGEN’s Ingenuity Pathway Analysis (IPA) to identify and analyze molecular pathways that affect the underlying connection between alpha-synuclein (SNCA)-associated Parkinson’s disease (PD) and infertility condition (IC). Furthermore, we explored nicotine’s potential as a therapeutic in preventing the exacerbation of IC in terms of SNCA. Results Although the connection between SNCA-related PD and IC is not well explored, the Qiagen Knowledge Base (QKB) showed an overlap of 12 distinct molecules between SNCA and IC. These molecular pathways were established by adding SNCA and IC to “Pathway Explorer” and establishing connections to distinct molecules including transcription regulators, cytokines, and other enzymes/proteins. The Molecule-Activity-Predictor (MAP) tool predicted that SNCA activation would lead to an exacerbation of PD and IC with the potential involvement of dihydrotestosterone (DHT) and caspases. Specifically, it was found that SNCA decreased MAPK8 expression, which led to a downstream upregulation of IC. Activation of nicotine within this overarching molecular network resulted in a downregulation in both PD pathology and IC. Conclusions Together, these findings reveal a possible connection between infertility condition and genes regularly associated with alpha-synuclein-related Parkinson’s disease while identifying nicotine as a potential therapeutic application. Graphical Abstract |
| first_indexed | 2024-03-09T15:28:44Z |
| format | Article |
| id | doaj.art-e2b3cf8a37ce4d40af97d239df160303 |
| institution | Directory Open Access Journal |
| issn | 2090-3251 |
| language | English |
| last_indexed | 2024-03-09T15:28:44Z |
| publishDate | 2023-09-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Middle East Fertility Society Journal |
| spelling | doaj.art-e2b3cf8a37ce4d40af97d239df1603032023-11-26T12:23:27ZengSpringerOpenMiddle East Fertility Society Journal2090-32512023-09-0128111610.1186/s43043-023-00148-4Bioinformatic network analysis on the molecular interactions between Parkinson’s disease, alpha-synuclein, and infertility conditionVelu Krishnan0Shivani S. Patel1Priyanka Shenoy2Jessica Cottrell3Department of Biological Sciences, College of Arts & Sciences, Seton Hall UniversityDepartment of Biological Sciences, College of Arts & Sciences, Seton Hall UniversityDepartment of Biological Sciences, College of Arts & Sciences, Seton Hall UniversityDepartment of Biological Sciences, College of Arts & Sciences, Seton Hall UniversityAbstract Background Parkinson’s disease (PD) is a neurodegenerative condition that is characterized by a progressive decline of neural pathways, and its pathology is associated with alpha-synuclein abnormalities. Currently, infertility affects about 10% of individuals of fertile age within the USA. Interestingly, an increased length of fertility is associated with a decreased incidence of PD. Our study utilized QIAGEN’s Ingenuity Pathway Analysis (IPA) to identify and analyze molecular pathways that affect the underlying connection between alpha-synuclein (SNCA)-associated Parkinson’s disease (PD) and infertility condition (IC). Furthermore, we explored nicotine’s potential as a therapeutic in preventing the exacerbation of IC in terms of SNCA. Results Although the connection between SNCA-related PD and IC is not well explored, the Qiagen Knowledge Base (QKB) showed an overlap of 12 distinct molecules between SNCA and IC. These molecular pathways were established by adding SNCA and IC to “Pathway Explorer” and establishing connections to distinct molecules including transcription regulators, cytokines, and other enzymes/proteins. The Molecule-Activity-Predictor (MAP) tool predicted that SNCA activation would lead to an exacerbation of PD and IC with the potential involvement of dihydrotestosterone (DHT) and caspases. Specifically, it was found that SNCA decreased MAPK8 expression, which led to a downstream upregulation of IC. Activation of nicotine within this overarching molecular network resulted in a downregulation in both PD pathology and IC. Conclusions Together, these findings reveal a possible connection between infertility condition and genes regularly associated with alpha-synuclein-related Parkinson’s disease while identifying nicotine as a potential therapeutic application. Graphical Abstracthttps://doi.org/10.1186/s43043-023-00148-4Ingenuity Pathway Analysis (IPA)Parkinson’s disease (PD)Infertility condition (IC)NicotineAlpha-synuclein (SNCA) |
| spellingShingle | Velu Krishnan Shivani S. Patel Priyanka Shenoy Jessica Cottrell Bioinformatic network analysis on the molecular interactions between Parkinson’s disease, alpha-synuclein, and infertility condition Middle East Fertility Society Journal Ingenuity Pathway Analysis (IPA) Parkinson’s disease (PD) Infertility condition (IC) Nicotine Alpha-synuclein (SNCA) |
| title | Bioinformatic network analysis on the molecular interactions between Parkinson’s disease, alpha-synuclein, and infertility condition |
| title_full | Bioinformatic network analysis on the molecular interactions between Parkinson’s disease, alpha-synuclein, and infertility condition |
| title_fullStr | Bioinformatic network analysis on the molecular interactions between Parkinson’s disease, alpha-synuclein, and infertility condition |
| title_full_unstemmed | Bioinformatic network analysis on the molecular interactions between Parkinson’s disease, alpha-synuclein, and infertility condition |
| title_short | Bioinformatic network analysis on the molecular interactions between Parkinson’s disease, alpha-synuclein, and infertility condition |
| title_sort | bioinformatic network analysis on the molecular interactions between parkinson s disease alpha synuclein and infertility condition |
| topic | Ingenuity Pathway Analysis (IPA) Parkinson’s disease (PD) Infertility condition (IC) Nicotine Alpha-synuclein (SNCA) |
| url | https://doi.org/10.1186/s43043-023-00148-4 |
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