A high Diabetes Risk Reduction Score (DRRS) is associated with a better cardio-metabolic profile among obese individuals
Abstract Background Dietary indices and scores are valuable predictive markers against chronic diseases. Several previous studies have revealed the beneficial effects of diabetes risk reduction score (DRRS) against diabetes and cancer incidence. However, its association with metabolic abnormalities...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-023-01279-5 |
| _version_ | 1811171728264527872 |
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| author | Goli Siri Negin Nikrad Sheida Keshavari Saideh Jamshidi Ehsan Fayyazishishavan Abnoos Mokhtari Ardekani Mahdieh Abbasalizad Farhangi Faria Jafarzadeh |
| author_facet | Goli Siri Negin Nikrad Sheida Keshavari Saideh Jamshidi Ehsan Fayyazishishavan Abnoos Mokhtari Ardekani Mahdieh Abbasalizad Farhangi Faria Jafarzadeh |
| author_sort | Goli Siri |
| collection | DOAJ |
| description | Abstract Background Dietary indices and scores are valuable predictive markers against chronic diseases. Several previous studies have revealed the beneficial effects of diabetes risk reduction score (DRRS) against diabetes and cancer incidence. However, its association with metabolic abnormalities among obese individuals have not been revealed before. In the current study, we aimed to investigate the association between DRRS and metabolic risk factors among obese individuals. Methods In the current cross-sectional study, 342 obese individuals [Body mass index (BMI) ≥ 30 kg/m2] aged 20–50 years were included. Dietary intake was assessed by a validated semi-quantitative food frequency questionnaire (FFQ) of 168 food items and DRRS was calculated. Metabolic syndrome (MetS) was defined based on the guidelines of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III). Enzymatic methods were used to assess serum lipids, glucose, and insulin concentrations. Blood pressure was measured by a sphygmomanometer and body composition with bioelectrical impedance analysis (BIA). Results Those with a higher adherence to DRRS had a significantly higher intake of energy, fiber, and lower protein compared with those in the lower quartiles. Moreover, lower intakes of trans fats, meat, sugar sweetened beverages (SSB), and glycemic index (GI) with higher intakes of fruits, cereal fiber, polyunsaturated fatty acids/ saturated fatty acids (PUFA/ SFA) ratio, coffee, and nuts were observed in the highest versus lowest DRRS categories. Lower systolic blood pressure, diastolic blood pressure, triglyceride and, higher high-density lipoprotein values were observed in higher DRRS categories. Logistic regression analysis showed that hypertension was significantly associated with adherence to DRRS among obese individuals, the odds ratio (OR) was 0.686 (95% confidence interval [CI], 0.26–0.84) after adjustment for potential confounders. But the risk of other components of MetS was not significantly associated with higher quartiles of adherence to DRRS. Also, a non-significantly lower prevalence of MetS was observed in the higher quartile of DRRS. Conclusions According to the results of the current study, higher DRRS was associated with lower blood pressure, modified serum lipids, and lower Mets prevalence. Further studies in different populations are warranted for better generalization of the obtained findings. |
| first_indexed | 2024-04-10T17:18:50Z |
| format | Article |
| id | doaj.art-e2b42d1f952b4e2dbcb7a2157ad709f4 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-04-10T17:18:50Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-e2b42d1f952b4e2dbcb7a2157ad709f42023-02-05T12:15:22ZengBMCBMC Endocrine Disorders1472-68232023-02-0123111010.1186/s12902-023-01279-5A high Diabetes Risk Reduction Score (DRRS) is associated with a better cardio-metabolic profile among obese individualsGoli Siri0Negin Nikrad1Sheida Keshavari2Saideh Jamshidi3Ehsan Fayyazishishavan4Abnoos Mokhtari Ardekani5Mahdieh Abbasalizad Farhangi6Faria Jafarzadeh7Department of Internal Medicine, Amir Alam Hospital, Tehran University of Medical SciencesDepartment of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical SciencesEchocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical SciencesEchocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical SciencesDepartment of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston (UTHealth)Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Science & Physiology Research Center, Kerman University of Medical SciencesDrug Applied Research Center, Tabriz University of Medical SciencesDepartment of Internal Medicine, School of Medicine, North Khorasan University of Medical SciencesAbstract Background Dietary indices and scores are valuable predictive markers against chronic diseases. Several previous studies have revealed the beneficial effects of diabetes risk reduction score (DRRS) against diabetes and cancer incidence. However, its association with metabolic abnormalities among obese individuals have not been revealed before. In the current study, we aimed to investigate the association between DRRS and metabolic risk factors among obese individuals. Methods In the current cross-sectional study, 342 obese individuals [Body mass index (BMI) ≥ 30 kg/m2] aged 20–50 years were included. Dietary intake was assessed by a validated semi-quantitative food frequency questionnaire (FFQ) of 168 food items and DRRS was calculated. Metabolic syndrome (MetS) was defined based on the guidelines of the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III). Enzymatic methods were used to assess serum lipids, glucose, and insulin concentrations. Blood pressure was measured by a sphygmomanometer and body composition with bioelectrical impedance analysis (BIA). Results Those with a higher adherence to DRRS had a significantly higher intake of energy, fiber, and lower protein compared with those in the lower quartiles. Moreover, lower intakes of trans fats, meat, sugar sweetened beverages (SSB), and glycemic index (GI) with higher intakes of fruits, cereal fiber, polyunsaturated fatty acids/ saturated fatty acids (PUFA/ SFA) ratio, coffee, and nuts were observed in the highest versus lowest DRRS categories. Lower systolic blood pressure, diastolic blood pressure, triglyceride and, higher high-density lipoprotein values were observed in higher DRRS categories. Logistic regression analysis showed that hypertension was significantly associated with adherence to DRRS among obese individuals, the odds ratio (OR) was 0.686 (95% confidence interval [CI], 0.26–0.84) after adjustment for potential confounders. But the risk of other components of MetS was not significantly associated with higher quartiles of adherence to DRRS. Also, a non-significantly lower prevalence of MetS was observed in the higher quartile of DRRS. Conclusions According to the results of the current study, higher DRRS was associated with lower blood pressure, modified serum lipids, and lower Mets prevalence. Further studies in different populations are warranted for better generalization of the obtained findings.https://doi.org/10.1186/s12902-023-01279-5Diabetes risk reductionMetabolic syndromeObesityMetabolic parametersDiabetes |
| spellingShingle | Goli Siri Negin Nikrad Sheida Keshavari Saideh Jamshidi Ehsan Fayyazishishavan Abnoos Mokhtari Ardekani Mahdieh Abbasalizad Farhangi Faria Jafarzadeh A high Diabetes Risk Reduction Score (DRRS) is associated with a better cardio-metabolic profile among obese individuals BMC Endocrine Disorders Diabetes risk reduction Metabolic syndrome Obesity Metabolic parameters Diabetes |
| title | A high Diabetes Risk Reduction Score (DRRS) is associated with a better cardio-metabolic profile among obese individuals |
| title_full | A high Diabetes Risk Reduction Score (DRRS) is associated with a better cardio-metabolic profile among obese individuals |
| title_fullStr | A high Diabetes Risk Reduction Score (DRRS) is associated with a better cardio-metabolic profile among obese individuals |
| title_full_unstemmed | A high Diabetes Risk Reduction Score (DRRS) is associated with a better cardio-metabolic profile among obese individuals |
| title_short | A high Diabetes Risk Reduction Score (DRRS) is associated with a better cardio-metabolic profile among obese individuals |
| title_sort | high diabetes risk reduction score drrs is associated with a better cardio metabolic profile among obese individuals |
| topic | Diabetes risk reduction Metabolic syndrome Obesity Metabolic parameters Diabetes |
| url | https://doi.org/10.1186/s12902-023-01279-5 |
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