SARS-CoV-2 spike-specific regulatory T cells (Treg) expand and develop memory in vaccine recipients suggesting a role for immune regulation in preventing severe symptoms in COVID-19

SARS-CoV-2 spike-specific regulatory T cells (Treg) expand and develop memory in vaccine recipients suggesting a role for immune regulation in preventing severe symptoms in COVID-19

We enrolled healthy subjects that received 2 to 4 injections of mRNA-based vaccination to prevent COVID-19 months to a year from the last vaccine boost, and we found numerous SARS-CoV-2 spike-specific regulatory T cell (Treg) that developed T cell memory as effector memory T cells (TEM) and central...

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Bibliographic Details
Main Authors: Alessandra Franco, Jaeyoon Song, Christina Chambers, Alessandro Sette, Alba Grifoni
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Autoimmunity
Subjects:
regulatory t cells (treg)
vaccine
sars-cov-2
immune regulation
t cell memory
Online Access:http://dx.doi.org/10.1080/08916934.2023.2259133

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