Combination administration of alprazolam and N-Ethylmaleimide synergistically enhances sleep behaviors in mice with no potential CNS side effects

Combination administration of alprazolam and N-Ethylmaleimide synergistically enhances sleep behaviors in mice with no potential CNS side effects

Background N-Ethylmaleimide (NEM), an agonist of the potassium chloride cotransporters 2 (KCC2) receptor, has been correlated with neurosuppressive outcomes, including decreased pain perception and the prevention of epileptic seizures. Nevertheless, its relationship with sleep-inducing effects remai...

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Bibliographic Details
Main Authors: Siqing Zhu, Jingjing Shi, Yi Zhang, Xuejun Chen, Tong Shi, Liqin Li
Format: Article
Language:English
Published: PeerJ Inc. 2024-05-01
Series:PeerJ
Subjects:
Combination
Alprazolam
KCC2
N-Ethylmaleimide
Enhanced
Sleep behaviors
Online Access:https://peerj.com/articles/17342.pdf

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https://peerj.com/articles/17342.pdf

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