Durable Complete Response to Pembrolizumab in Esophageal Squamous Cell Carcinoma With Divergent Microsatellite Status: A Case Report

Durable Complete Response to Pembrolizumab in Esophageal Squamous Cell Carcinoma With Divergent Microsatellite Status: A Case Report

Microsatellite instability-high (MSI-H) is widely believed to be a biomarker for immune checkpoint inhibitors (ICIs) such as pembrolizumab in solid tumors. However, due to the low prevalence of MSI-H in most cancers, it tends to be insufficient to identify whether patients should receive ICIs accord...

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Bibliographic Details
Main Authors: Tian Zeng, Lei Zhang, Can Chen, Xiang Zhao, Xiaoqing Liu, Fengwei Ran, Tingting Yong, Ying Yang, Henghui Zhang, Yanling Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Oncology
Subjects:
esophageal squamous cell carcinoma
microsatellite instability
pembrolizumab
complete response
DNA damage repair
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.767957/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.767957/full

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