Synthesis of Ring II/III Fragment of Kanamycin: A New Minimum Structural Motif for Aminoglycoside Recognition

Synthesis of Ring II/III Fragment of Kanamycin: A New Minimum Structural Motif for Aminoglycoside Recognition

A novel protocol has been established to prepare the kanamycin ring II/III fragment, which has been validated as a minimum structural motif for the development of new aminoglycosides on the basis of its bactericidal activity even against resistant strains. Furthermore, its ability to act as a AAC-(6...

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Bibliographic Details
Main Authors: Sandra G. Zárate, Agatha Bastida, Andrés G. Santana, Julia Revuelta
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Antibiotics
Subjects:
aminoglycoside antibiotics
enzymatic resistance
minimum structural motif
oligosaccharides
pseudo-disaccharide
Online Access:https://www.mdpi.com/2079-6382/8/3/109

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