Efficacy of Probiotic Supplements on Brain-Derived Neurotrophic Factor, Inflammatory Biomarkers, Oxidative Stress and Cognitive Function in Patients with Alzheimer’s Dementia: A 12-Week Randomized, Double-Blind Active-Controlled Study
The role of neurotrophic factors, oxidative stress, and inflammation in the pathogenesis of Alzheimer’s disease (AD) has been explored. Animal studies have reported the positive effects of probiotics on these factors. Some clinical studies also support the potential role of probiotics in improving c...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/1/16 |
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| author | Yu-Chieh Hsu Yen-Yu Huang Shin-Yu Tsai Yi-Wei Kuo Jia-Hung Lin Hsieh-Hsun Ho Jui-Fen Chen Ko-Chiang Hsia Yu Sun |
| author_facet | Yu-Chieh Hsu Yen-Yu Huang Shin-Yu Tsai Yi-Wei Kuo Jia-Hung Lin Hsieh-Hsun Ho Jui-Fen Chen Ko-Chiang Hsia Yu Sun |
| author_sort | Yu-Chieh Hsu |
| collection | DOAJ |
| description | The role of neurotrophic factors, oxidative stress, and inflammation in the pathogenesis of Alzheimer’s disease (AD) has been explored. Animal studies have reported the positive effects of probiotics on these factors. Some clinical studies also support the potential role of probiotics in improving cognitive function via the gut–brain axis in older adults. However, clinical experimental studies evaluating the efficacy of probiotics targeting the neurotrophic factors and inflammatory biomarkers, particularly among AD patients, remain very limited. In this randomized, double-blinded, active-controlled trial, we used multi-strain probiotic supplements, including <i>Bifidobacterium longum</i> subsp. <i>infantis</i> BLI-02, <i>B. breve</i> Bv-889, <i>B. animalis</i> subsp. <i>lactis</i> CP-9, <i>B. bifidum</i> VDD088, and <i>Lactobacillus plantarum</i> PL-02 as the intervention. Participants were divided into an active control group (received probiotic supplements containing 5 × 10<sup>7</sup> colony-forming units per day, CFU/day) and a treatment group (1 × 10<sup>10</sup> CFU/day). Student’s <i>t</i> test was applied as the main method of statistical analysis. After 12 weeks of intervention, the treatment group demonstrated a 36% increase in serum brain-derived neurotrophic factor (BDNF) (* <i>p</i> = 0.005), a reduction in IL-1β (* <i>p</i> = 0.041), and an increase in antioxidant superoxide dismutase (SOD) (* <i>p</i> = 0.012). No significant change was found in the active control group. A trend toward less cognitive deterioration was observed, but not statistically significant. In conclusion, this study presents evidence supporting the benefits of multi-strain probiotics in enhancing BDNF, ameliorating inflammation and oxidative stress in AD patients. |
| first_indexed | 2024-03-08T15:00:47Z |
| format | Article |
| id | doaj.art-e2ba354c4bb441c3b179576628f493b8 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-08T15:00:47Z |
| publishDate | 2023-12-01 |
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| series | Nutrients |
| spelling | doaj.art-e2ba354c4bb441c3b179576628f493b82024-01-10T15:05:14ZengMDPI AGNutrients2072-66432023-12-011611610.3390/nu16010016Efficacy of Probiotic Supplements on Brain-Derived Neurotrophic Factor, Inflammatory Biomarkers, Oxidative Stress and Cognitive Function in Patients with Alzheimer’s Dementia: A 12-Week Randomized, Double-Blind Active-Controlled StudyYu-Chieh Hsu0Yen-Yu Huang1Shin-Yu Tsai2Yi-Wei Kuo3Jia-Hung Lin4Hsieh-Hsun Ho5Jui-Fen Chen6Ko-Chiang Hsia7Yu Sun8Department of Research and Design, Glac Biotech Co., Ltd., Tainan 744, TaiwanDepartment of Research and Design, Glac Biotech Co., Ltd., Tainan 744, TaiwanDepartment of Research and Design, Glac Biotech Co., Ltd., Tainan 744, TaiwanDepartment of Research and Design, Glac Biotech Co., Ltd., Tainan 744, TaiwanDepartment of Research and Design, Glac Biotech Co., Ltd., Tainan 744, TaiwanDepartment of Research and Design, Glac Biotech Co., Ltd., Tainan 744, TaiwanDepartment of Research and Design, Glac Biotech Co., Ltd., Tainan 744, TaiwanDepartment of Research and Design, Glac Biotech Co., Ltd., Tainan 744, TaiwanDepartment of Neurology, En Chu Kong Hospital, New Taipei City 237, TaiwanThe role of neurotrophic factors, oxidative stress, and inflammation in the pathogenesis of Alzheimer’s disease (AD) has been explored. Animal studies have reported the positive effects of probiotics on these factors. Some clinical studies also support the potential role of probiotics in improving cognitive function via the gut–brain axis in older adults. However, clinical experimental studies evaluating the efficacy of probiotics targeting the neurotrophic factors and inflammatory biomarkers, particularly among AD patients, remain very limited. In this randomized, double-blinded, active-controlled trial, we used multi-strain probiotic supplements, including <i>Bifidobacterium longum</i> subsp. <i>infantis</i> BLI-02, <i>B. breve</i> Bv-889, <i>B. animalis</i> subsp. <i>lactis</i> CP-9, <i>B. bifidum</i> VDD088, and <i>Lactobacillus plantarum</i> PL-02 as the intervention. Participants were divided into an active control group (received probiotic supplements containing 5 × 10<sup>7</sup> colony-forming units per day, CFU/day) and a treatment group (1 × 10<sup>10</sup> CFU/day). Student’s <i>t</i> test was applied as the main method of statistical analysis. After 12 weeks of intervention, the treatment group demonstrated a 36% increase in serum brain-derived neurotrophic factor (BDNF) (* <i>p</i> = 0.005), a reduction in IL-1β (* <i>p</i> = 0.041), and an increase in antioxidant superoxide dismutase (SOD) (* <i>p</i> = 0.012). No significant change was found in the active control group. A trend toward less cognitive deterioration was observed, but not statistically significant. In conclusion, this study presents evidence supporting the benefits of multi-strain probiotics in enhancing BDNF, ameliorating inflammation and oxidative stress in AD patients.https://www.mdpi.com/2072-6643/16/1/16Alzheimer’s diseaseprobioticsbrain-derived neurotrophic factor (BDNF)cognitive functionoxidative stressanti-inflammation |
| spellingShingle | Yu-Chieh Hsu Yen-Yu Huang Shin-Yu Tsai Yi-Wei Kuo Jia-Hung Lin Hsieh-Hsun Ho Jui-Fen Chen Ko-Chiang Hsia Yu Sun Efficacy of Probiotic Supplements on Brain-Derived Neurotrophic Factor, Inflammatory Biomarkers, Oxidative Stress and Cognitive Function in Patients with Alzheimer’s Dementia: A 12-Week Randomized, Double-Blind Active-Controlled Study Nutrients Alzheimer’s disease probiotics brain-derived neurotrophic factor (BDNF) cognitive function oxidative stress anti-inflammation |
| title | Efficacy of Probiotic Supplements on Brain-Derived Neurotrophic Factor, Inflammatory Biomarkers, Oxidative Stress and Cognitive Function in Patients with Alzheimer’s Dementia: A 12-Week Randomized, Double-Blind Active-Controlled Study |
| title_full | Efficacy of Probiotic Supplements on Brain-Derived Neurotrophic Factor, Inflammatory Biomarkers, Oxidative Stress and Cognitive Function in Patients with Alzheimer’s Dementia: A 12-Week Randomized, Double-Blind Active-Controlled Study |
| title_fullStr | Efficacy of Probiotic Supplements on Brain-Derived Neurotrophic Factor, Inflammatory Biomarkers, Oxidative Stress and Cognitive Function in Patients with Alzheimer’s Dementia: A 12-Week Randomized, Double-Blind Active-Controlled Study |
| title_full_unstemmed | Efficacy of Probiotic Supplements on Brain-Derived Neurotrophic Factor, Inflammatory Biomarkers, Oxidative Stress and Cognitive Function in Patients with Alzheimer’s Dementia: A 12-Week Randomized, Double-Blind Active-Controlled Study |
| title_short | Efficacy of Probiotic Supplements on Brain-Derived Neurotrophic Factor, Inflammatory Biomarkers, Oxidative Stress and Cognitive Function in Patients with Alzheimer’s Dementia: A 12-Week Randomized, Double-Blind Active-Controlled Study |
| title_sort | efficacy of probiotic supplements on brain derived neurotrophic factor inflammatory biomarkers oxidative stress and cognitive function in patients with alzheimer s dementia a 12 week randomized double blind active controlled study |
| topic | Alzheimer’s disease probiotics brain-derived neurotrophic factor (BDNF) cognitive function oxidative stress anti-inflammation |
| url | https://www.mdpi.com/2072-6643/16/1/16 |
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