Long-acting injectable atovaquone nanomedicines for malaria prophylaxis
Long-acting antimalarials could provide improved prophylaxis and treatment options in the field. Here, Bakshi et al. develop a long-acting injectable atovaquone nanomedicine that prevents malaria infection prophylactically for up to 4 weeks in mice with no evidence for generation of resistant parasi...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-01-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-02603-z |
| _version_ | 1818992652566134784 |
|---|---|
| author | Rahul P. Bakshi Lee M. Tatham Alison C. Savage Abhai K. Tripathi Godfree Mlambo Matthew M. Ippolito Elizabeth Nenortas Steve P. Rannard Andrew Owen Theresa A. Shapiro |
| author_facet | Rahul P. Bakshi Lee M. Tatham Alison C. Savage Abhai K. Tripathi Godfree Mlambo Matthew M. Ippolito Elizabeth Nenortas Steve P. Rannard Andrew Owen Theresa A. Shapiro |
| author_sort | Rahul P. Bakshi |
| collection | DOAJ |
| description | Long-acting antimalarials could provide improved prophylaxis and treatment options in the field. Here, Bakshi et al. develop a long-acting injectable atovaquone nanomedicine that prevents malaria infection prophylactically for up to 4 weeks in mice with no evidence for generation of resistant parasites. |
| first_indexed | 2024-12-20T20:29:34Z |
| format | Article |
| id | doaj.art-e2bbca833b9043c393d3ffbbdc23b805 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:29:34Z |
| publishDate | 2018-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e2bbca833b9043c393d3ffbbdc23b8052022-12-21T19:27:24ZengNature PortfolioNature Communications2041-17232018-01-01911810.1038/s41467-017-02603-zLong-acting injectable atovaquone nanomedicines for malaria prophylaxisRahul P. Bakshi0Lee M. Tatham1Alison C. Savage2Abhai K. Tripathi3Godfree Mlambo4Matthew M. Ippolito5Elizabeth Nenortas6Steve P. Rannard7Andrew Owen8Theresa A. Shapiro9Division of Clinical Pharmacology, Departments of Medicine and of Pharmacology and Molecular Sciences, The Johns Hopkins UniversityDepartment of Molecular and Clinical Pharmacology, University of LiverpoolDepartment of Chemistry, University of LiverpoolThe Johns Hopkins Malaria Research InstituteThe Johns Hopkins Malaria Research InstituteDivision of Clinical Pharmacology, Departments of Medicine and of Pharmacology and Molecular Sciences, The Johns Hopkins UniversityDivision of Clinical Pharmacology, Departments of Medicine and of Pharmacology and Molecular Sciences, The Johns Hopkins UniversityDepartment of Chemistry, University of LiverpoolDepartment of Molecular and Clinical Pharmacology, University of LiverpoolDivision of Clinical Pharmacology, Departments of Medicine and of Pharmacology and Molecular Sciences, The Johns Hopkins UniversityLong-acting antimalarials could provide improved prophylaxis and treatment options in the field. Here, Bakshi et al. develop a long-acting injectable atovaquone nanomedicine that prevents malaria infection prophylactically for up to 4 weeks in mice with no evidence for generation of resistant parasites.https://doi.org/10.1038/s41467-017-02603-z |
| spellingShingle | Rahul P. Bakshi Lee M. Tatham Alison C. Savage Abhai K. Tripathi Godfree Mlambo Matthew M. Ippolito Elizabeth Nenortas Steve P. Rannard Andrew Owen Theresa A. Shapiro Long-acting injectable atovaquone nanomedicines for malaria prophylaxis Nature Communications |
| title | Long-acting injectable atovaquone nanomedicines for malaria prophylaxis |
| title_full | Long-acting injectable atovaquone nanomedicines for malaria prophylaxis |
| title_fullStr | Long-acting injectable atovaquone nanomedicines for malaria prophylaxis |
| title_full_unstemmed | Long-acting injectable atovaquone nanomedicines for malaria prophylaxis |
| title_short | Long-acting injectable atovaquone nanomedicines for malaria prophylaxis |
| title_sort | long acting injectable atovaquone nanomedicines for malaria prophylaxis |
| url | https://doi.org/10.1038/s41467-017-02603-z |
| work_keys_str_mv | AT rahulpbakshi longactinginjectableatovaquonenanomedicinesformalariaprophylaxis AT leemtatham longactinginjectableatovaquonenanomedicinesformalariaprophylaxis AT alisoncsavage longactinginjectableatovaquonenanomedicinesformalariaprophylaxis AT abhaiktripathi longactinginjectableatovaquonenanomedicinesformalariaprophylaxis AT godfreemlambo longactinginjectableatovaquonenanomedicinesformalariaprophylaxis AT matthewmippolito longactinginjectableatovaquonenanomedicinesformalariaprophylaxis AT elizabethnenortas longactinginjectableatovaquonenanomedicinesformalariaprophylaxis AT steveprannard longactinginjectableatovaquonenanomedicinesformalariaprophylaxis AT andrewowen longactinginjectableatovaquonenanomedicinesformalariaprophylaxis AT theresaashapiro longactinginjectableatovaquonenanomedicinesformalariaprophylaxis |