Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation
In this article, we will review some behavioral, pharmacological and neurochemical studies from our laboratory on mice, which might contribute to our understanding of the complex processes of memory consolidation and reconsolidation. We discuss the post-training (memory consolidation) and post-react...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2009-02-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000200001 |
| _version_ | 1811240109151879168 |
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| author | C.M. Baratti M.M. Boccia M.G. Blake |
| author_facet | C.M. Baratti M.M. Boccia M.G. Blake |
| author_sort | C.M. Baratti |
| collection | DOAJ |
| description | In this article, we will review some behavioral, pharmacological and neurochemical studies from our laboratory on mice, which might contribute to our understanding of the complex processes of memory consolidation and reconsolidation. We discuss the post-training (memory consolidation) and post-reactivation (memory reconsolidation) effects of icv infusions of hemicholinium, a central inhibitor of acetylcholine synthesis, of intraperitoneal administration of L-NAME, a non-specific inhibitor of nitric oxide synthase, of intrahippocampal injections of an inhibitor of the transcription factor NF-κB, and the exposure of mice to a new learning situation on retention performance of an inhibitory avoidance response. All treatments impair long-term memory consolidation and retrieval-induced memory processes different from extinction, probably in accordance with the "reconsolidation hypothesis". |
| first_indexed | 2024-04-12T13:14:38Z |
| format | Article |
| id | doaj.art-e2beb62ae22f49e4ac5ea128538196f7 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-04-12T13:14:38Z |
| publishDate | 2009-02-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-e2beb62ae22f49e4ac5ea128538196f72022-12-22T03:31:46ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2009-02-0142214815410.1590/S0100-879X2009000200001Pharmacological effects and behavioral interventions on memory consolidation and reconsolidationC.M. BarattiM.M. BocciaM.G. BlakeIn this article, we will review some behavioral, pharmacological and neurochemical studies from our laboratory on mice, which might contribute to our understanding of the complex processes of memory consolidation and reconsolidation. We discuss the post-training (memory consolidation) and post-reactivation (memory reconsolidation) effects of icv infusions of hemicholinium, a central inhibitor of acetylcholine synthesis, of intraperitoneal administration of L-NAME, a non-specific inhibitor of nitric oxide synthase, of intrahippocampal injections of an inhibitor of the transcription factor NF-κB, and the exposure of mice to a new learning situation on retention performance of an inhibitory avoidance response. All treatments impair long-term memory consolidation and retrieval-induced memory processes different from extinction, probably in accordance with the "reconsolidation hypothesis".http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000200001MemoryConsolidationReconsolidationExtinctionInhibitory avoidance |
| spellingShingle | C.M. Baratti M.M. Boccia M.G. Blake Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation Brazilian Journal of Medical and Biological Research Memory Consolidation Reconsolidation Extinction Inhibitory avoidance |
| title | Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation |
| title_full | Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation |
| title_fullStr | Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation |
| title_full_unstemmed | Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation |
| title_short | Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation |
| title_sort | pharmacological effects and behavioral interventions on memory consolidation and reconsolidation |
| topic | Memory Consolidation Reconsolidation Extinction Inhibitory avoidance |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2009000200001 |
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