Virilizing Adrenocortical Carcinoma Oncocytic Variant in a Child with Heterosexual Precocious Puberty and a Literature Review
Androgen-secreting adrenal tumors are aggressive cancers in childhood; however, they are rare in clinical practice. Children with adrenal carcinoma usually present with peripheral precocious puberty, premature pubarche, signs of virilization and clitoromegaly. We present a case of 4 year-old girl wi...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2022-09-01
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| Series: | Journal of Pediatric Research |
| Subjects: | |
| Online Access: |
http://jpedres.org/archives/archive-detail/article-preview/virilizing-adrenocortical-carcinoma-oncocytic-vari/52813
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| _version_ | 1797910332258123776 |
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| author | Seyran Bulut Gönül Çatlı Berna Eroğlu Filibeli Hayrullah Manyas İlkay Ayrancı Rabia Meral Deniz Kızmazoğlu Bumin Nuri Dündar |
| author_facet | Seyran Bulut Gönül Çatlı Berna Eroğlu Filibeli Hayrullah Manyas İlkay Ayrancı Rabia Meral Deniz Kızmazoğlu Bumin Nuri Dündar |
| author_sort | Seyran Bulut |
| collection | DOAJ |
| description | Androgen-secreting adrenal tumors are aggressive cancers in childhood; however, they are rare in clinical practice. Children with adrenal carcinoma usually present with peripheral precocious puberty, premature pubarche, signs of virilization and clitoromegaly. We present a case of 4 year-old girl with premature pubarche, clitoromegaly and bone age advancement, who was subsequently diagnosed with pure androgen-secreting oncocytic adrenal carcinoma. After the removal of the adrenal tumor, our patient developed precocious puberty. In patients with functioning adrenocortical carcinoma who have had surgical removal, clinical follow-up and hormonal marker examination for the secondary effects of excessive hormone secretion at least every 2 or 3 months may be a useful option after surgery. The aim of this article is to emphasize that adrenal tumors can be seen in patients presenting with virilization findings. We also present a literature review of these tumors, which are very rare in childhood. |
| first_indexed | 2024-04-10T11:22:48Z |
| format | Article |
| id | doaj.art-e2bf000d396f438c8f4375d85b5a088c |
| institution | Directory Open Access Journal |
| issn | 2147-9445 2587-2478 |
| language | English |
| last_indexed | 2024-04-10T11:22:48Z |
| publishDate | 2022-09-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Journal of Pediatric Research |
| spelling | doaj.art-e2bf000d396f438c8f4375d85b5a088c2023-02-15T16:18:34ZengGalenos YayineviJournal of Pediatric Research2147-94452587-24782022-09-019330731310.4274/jpr.galenos.2022.0557913049054Virilizing Adrenocortical Carcinoma Oncocytic Variant in a Child with Heterosexual Precocious Puberty and a Literature ReviewSeyran Bulut0Gönül Çatlı1Berna Eroğlu Filibeli2Hayrullah Manyas3İlkay Ayrancı4Rabia Meral5Deniz Kızmazoğlu6Bumin Nuri Dündar7 University of Health Sciences Turkey, İzmir Tepecik Training and Research Hospital, Clinic of Pediatric Endocrinology, İzmir, Turkey İzmir Katip Çelebi University Faculty of Medicine, Department of Pediatric Endocrinology, İzmir, Turkey University of Health Sciences Turkey, İzmir Tepecik Training and Research Hospital, Clinic of Pediatric Endocrinology, İzmir, Turkey University of Health Sciences Turkey, İzmir Tepecik Training and Research Hospital, Clinic of Pediatric Endocrinology, İzmir, Turkey University of Health Sciences Turkey, İzmir Tepecik Training and Research Hospital, Clinic of Pediatric Endocrinology, İzmir, Turkey University of Health Sciences Turkey, İzmir Tepecik Training and Research Hospital, Clinic of Pediatric Endocrinology, İzmir, Turkey University of Health Sciences Turkey, İzmir Tepecik Training and Research Hospital, Clinic of Pediatric Hematology and Oncology, İzmir, Turkey İzmir Katip Çelebi University Faculty of Medicine, Department of Pediatric Endocrinology, İzmir, Turkey Androgen-secreting adrenal tumors are aggressive cancers in childhood; however, they are rare in clinical practice. Children with adrenal carcinoma usually present with peripheral precocious puberty, premature pubarche, signs of virilization and clitoromegaly. We present a case of 4 year-old girl with premature pubarche, clitoromegaly and bone age advancement, who was subsequently diagnosed with pure androgen-secreting oncocytic adrenal carcinoma. After the removal of the adrenal tumor, our patient developed precocious puberty. In patients with functioning adrenocortical carcinoma who have had surgical removal, clinical follow-up and hormonal marker examination for the secondary effects of excessive hormone secretion at least every 2 or 3 months may be a useful option after surgery. The aim of this article is to emphasize that adrenal tumors can be seen in patients presenting with virilization findings. We also present a literature review of these tumors, which are very rare in childhood. http://jpedres.org/archives/archive-detail/article-preview/virilizing-adrenocortical-carcinoma-oncocytic-vari/52813 oncocytic variant adrenocortical cancerperipheral precocious pubertyclitoromegaly |
| spellingShingle | Seyran Bulut Gönül Çatlı Berna Eroğlu Filibeli Hayrullah Manyas İlkay Ayrancı Rabia Meral Deniz Kızmazoğlu Bumin Nuri Dündar Virilizing Adrenocortical Carcinoma Oncocytic Variant in a Child with Heterosexual Precocious Puberty and a Literature Review Journal of Pediatric Research oncocytic variant adrenocortical cancer peripheral precocious puberty clitoromegaly |
| title | Virilizing Adrenocortical Carcinoma Oncocytic Variant in a Child with Heterosexual Precocious Puberty and a Literature Review |
| title_full | Virilizing Adrenocortical Carcinoma Oncocytic Variant in a Child with Heterosexual Precocious Puberty and a Literature Review |
| title_fullStr | Virilizing Adrenocortical Carcinoma Oncocytic Variant in a Child with Heterosexual Precocious Puberty and a Literature Review |
| title_full_unstemmed | Virilizing Adrenocortical Carcinoma Oncocytic Variant in a Child with Heterosexual Precocious Puberty and a Literature Review |
| title_short | Virilizing Adrenocortical Carcinoma Oncocytic Variant in a Child with Heterosexual Precocious Puberty and a Literature Review |
| title_sort | virilizing adrenocortical carcinoma oncocytic variant in a child with heterosexual precocious puberty and a literature review |
| topic | oncocytic variant adrenocortical cancer peripheral precocious puberty clitoromegaly |
| url |
http://jpedres.org/archives/archive-detail/article-preview/virilizing-adrenocortical-carcinoma-oncocytic-vari/52813
|
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