Perspectives for the Use of Umbilical Cord Blood in Transplantation and Beyond: Initiatives for an Advanced and Sustainable Public Banking Program in Greece
The umbilical cord blood (UCB) donated in public UCB banks is a source of hematopoietic stem cells (HSC) alternative to bone marrow for allogeneic HSC transplantation (HSCT). However, the high rejection rate of the donated units due to the strict acceptance criteria and the wide application of the h...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/4/1152 |
| _version_ | 1797297905405526016 |
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| author | Patra Pateraki Helen Latsoudis Anastasia Papadopoulou Ioanna Gontika Irene Fragiadaki Irene Mavroudi Nikoleta Bizymi Aristea Batsali Michail E. Klontzas Angeliki Xagorari Efstathios Michalopoulos Damianos Sotiropoulos Evangelia Yannaki Catherine Stavropoulos-Giokas Helen A. Papadaki |
| author_facet | Patra Pateraki Helen Latsoudis Anastasia Papadopoulou Ioanna Gontika Irene Fragiadaki Irene Mavroudi Nikoleta Bizymi Aristea Batsali Michail E. Klontzas Angeliki Xagorari Efstathios Michalopoulos Damianos Sotiropoulos Evangelia Yannaki Catherine Stavropoulos-Giokas Helen A. Papadaki |
| author_sort | Patra Pateraki |
| collection | DOAJ |
| description | The umbilical cord blood (UCB) donated in public UCB banks is a source of hematopoietic stem cells (HSC) alternative to bone marrow for allogeneic HSC transplantation (HSCT). However, the high rejection rate of the donated units due to the strict acceptance criteria and the wide application of the haploidentical HSCT have resulted in significant limitation of the use of UCB and difficulties in the economic sustainability of the public UCB banks. There is an ongoing effort within the UCB community to optimize the use of UCB in the field of HSCT and a parallel interest in exploring the use of UCB for applications beyond HSCT i.e., in the fields of cell therapy, regenerative medicine and specialized transfusion medicine. In this report, we describe the mode of operation of the three public UCB banks in Greece as an example of an orchestrated effort to develop a viable UCB banking system by (a) prioritizing the enrichment of the national inventory by high-quality UCB units from populations with rare human leukocyte antigens (HLA), and (b) deploying novel sustainable applications of UCB beyond HSCT, through national and international collaborations. The Greek paradigm of the public UCB network may become an example for countries, particularly with high HLA heterogeneity, with public UCB banks facing sustainability difficulties and adds value to the international efforts aiming to sustainably expand the public UCB banking system. |
| first_indexed | 2024-03-07T22:27:08Z |
| format | Article |
| id | doaj.art-e2c0780688e54f5ab37ea4f09b039db6 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-07T22:27:08Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-e2c0780688e54f5ab37ea4f09b039db62024-02-23T15:22:26ZengMDPI AGJournal of Clinical Medicine2077-03832024-02-01134115210.3390/jcm13041152Perspectives for the Use of Umbilical Cord Blood in Transplantation and Beyond: Initiatives for an Advanced and Sustainable Public Banking Program in GreecePatra Pateraki0Helen Latsoudis1Anastasia Papadopoulou2Ioanna Gontika3Irene Fragiadaki4Irene Mavroudi5Nikoleta Bizymi6Aristea Batsali7Michail E. Klontzas8Angeliki Xagorari9Efstathios Michalopoulos10Damianos Sotiropoulos11Evangelia Yannaki12Catherine Stavropoulos-Giokas13Helen A. Papadaki14Law Directorate of the Health Region of Crete, Ministry of Health, Heraklion, 71500 Heraklion, GreeceInstitute of Computer Sciences, Foundation for Research and Technology–Hellas (FORTH), 70013 Heraklion, GreeceGene and Cell Therapy Center, Department of Hematology-HCT Unit, George Papanikolaou Hospital, 57010 Thessaloniki, GreecePublic Cord Blood Bank of Crete, Department of Hematology, University Hospital of Heraklion, 71500 Heraklion, GreecePublic Cord Blood Bank of Crete, Department of Hematology, University Hospital of Heraklion, 71500 Heraklion, GreecePublic Cord Blood Bank of Crete, Department of Hematology, University Hospital of Heraklion, 71500 Heraklion, GreecePublic Cord Blood Bank of Crete, Department of Hematology, University Hospital of Heraklion, 71500 Heraklion, GreecePublic Cord Blood Bank of Crete, Department of Hematology, University Hospital of Heraklion, 71500 Heraklion, GreeceDepartment of Radiology, School of Medicine, University of Crete, 71500 Heraklion, GreecePublic Cord Blood Bank, Department of Hematology, George Papanikolaou Hospital, 57010 Thessaloniki, GreeceHellenic Cord Blood Bank (HCBB), Biomedical Research Foundation Academy of Athens, 11527 Athens, GreecePublic Cord Blood Bank, Department of Hematology, George Papanikolaou Hospital, 57010 Thessaloniki, GreeceGene and Cell Therapy Center, Department of Hematology-HCT Unit, George Papanikolaou Hospital, 57010 Thessaloniki, GreeceHellenic Cord Blood Bank (HCBB), Biomedical Research Foundation Academy of Athens, 11527 Athens, GreecePublic Cord Blood Bank of Crete, Department of Hematology, University Hospital of Heraklion, 71500 Heraklion, GreeceThe umbilical cord blood (UCB) donated in public UCB banks is a source of hematopoietic stem cells (HSC) alternative to bone marrow for allogeneic HSC transplantation (HSCT). However, the high rejection rate of the donated units due to the strict acceptance criteria and the wide application of the haploidentical HSCT have resulted in significant limitation of the use of UCB and difficulties in the economic sustainability of the public UCB banks. There is an ongoing effort within the UCB community to optimize the use of UCB in the field of HSCT and a parallel interest in exploring the use of UCB for applications beyond HSCT i.e., in the fields of cell therapy, regenerative medicine and specialized transfusion medicine. In this report, we describe the mode of operation of the three public UCB banks in Greece as an example of an orchestrated effort to develop a viable UCB banking system by (a) prioritizing the enrichment of the national inventory by high-quality UCB units from populations with rare human leukocyte antigens (HLA), and (b) deploying novel sustainable applications of UCB beyond HSCT, through national and international collaborations. The Greek paradigm of the public UCB network may become an example for countries, particularly with high HLA heterogeneity, with public UCB banks facing sustainability difficulties and adds value to the international efforts aiming to sustainably expand the public UCB banking system.https://www.mdpi.com/2077-0383/13/4/1152umbilical cord blood (UCB)umbilical cord blood bankshematopoietic stem cell transplantation (HSCT)human leukocyte antigens (HLA)mesenchymal stem cells (MSC)induced pluripotent stem cells (iPSC) |
| spellingShingle | Patra Pateraki Helen Latsoudis Anastasia Papadopoulou Ioanna Gontika Irene Fragiadaki Irene Mavroudi Nikoleta Bizymi Aristea Batsali Michail E. Klontzas Angeliki Xagorari Efstathios Michalopoulos Damianos Sotiropoulos Evangelia Yannaki Catherine Stavropoulos-Giokas Helen A. Papadaki Perspectives for the Use of Umbilical Cord Blood in Transplantation and Beyond: Initiatives for an Advanced and Sustainable Public Banking Program in Greece Journal of Clinical Medicine umbilical cord blood (UCB) umbilical cord blood banks hematopoietic stem cell transplantation (HSCT) human leukocyte antigens (HLA) mesenchymal stem cells (MSC) induced pluripotent stem cells (iPSC) |
| title | Perspectives for the Use of Umbilical Cord Blood in Transplantation and Beyond: Initiatives for an Advanced and Sustainable Public Banking Program in Greece |
| title_full | Perspectives for the Use of Umbilical Cord Blood in Transplantation and Beyond: Initiatives for an Advanced and Sustainable Public Banking Program in Greece |
| title_fullStr | Perspectives for the Use of Umbilical Cord Blood in Transplantation and Beyond: Initiatives for an Advanced and Sustainable Public Banking Program in Greece |
| title_full_unstemmed | Perspectives for the Use of Umbilical Cord Blood in Transplantation and Beyond: Initiatives for an Advanced and Sustainable Public Banking Program in Greece |
| title_short | Perspectives for the Use of Umbilical Cord Blood in Transplantation and Beyond: Initiatives for an Advanced and Sustainable Public Banking Program in Greece |
| title_sort | perspectives for the use of umbilical cord blood in transplantation and beyond initiatives for an advanced and sustainable public banking program in greece |
| topic | umbilical cord blood (UCB) umbilical cord blood banks hematopoietic stem cell transplantation (HSCT) human leukocyte antigens (HLA) mesenchymal stem cells (MSC) induced pluripotent stem cells (iPSC) |
| url | https://www.mdpi.com/2077-0383/13/4/1152 |
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