Antiviral, Antifungal and Antibacterial Activities of a BODIPY-Based Photosensitizer
Antimicrobial photodynamic inactivation (aPDI) employing the BODIPY-based photosensitizer 2,6-diiodo-1,3,5,7-tetramethyl-8-(N-methyl-4-pyridyl)-4,4′-difluoro-boradiazaindacene (DIMPy-BODIPY) was explored in an in vitro assay against six species of bacteria (eight total strains), three species of yea...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-06-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/20/6/10604 |
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| author | Bradley L. Carpenter Xingci Situ Frank Scholle Juergen Bartelmess Walter W. Weare Reza A. Ghiladi |
| author_facet | Bradley L. Carpenter Xingci Situ Frank Scholle Juergen Bartelmess Walter W. Weare Reza A. Ghiladi |
| author_sort | Bradley L. Carpenter |
| collection | DOAJ |
| description | Antimicrobial photodynamic inactivation (aPDI) employing the BODIPY-based photosensitizer 2,6-diiodo-1,3,5,7-tetramethyl-8-(N-methyl-4-pyridyl)-4,4′-difluoro-boradiazaindacene (DIMPy-BODIPY) was explored in an in vitro assay against six species of bacteria (eight total strains), three species of yeast, and three viruses as a complementary approach to their current drug-based or non-existent treatments. Our best results achieved a noteworthy 5–6 log unit reduction in CFU at 0.1 μM for Staphylococcus aureus (ATCC-2913), methicillin-resistant S. aureus (ATCC-44), and vancomycin-resistant Enterococcus faecium (ATCC-2320), a 4–5 log unit reduction for Acinetobacter baumannii ATCC-19606 (0.25 μM), multidrug resistant A. baumannii ATCC-1605 (0.1 μM), Pseudomonas aeruginosa ATCC-97 (0.5 μM), and Klebsiella pneumoniae ATCC-2146 (1 μM), and a 3 log unit reduction for Mycobacterium smegmatis mc2155 (ATCC-700084). A 5 log unit reduction in CFU was observed for Candida albicans ATCC-90028 (1 μM) and Cryptococcus neoformans ATCC-64538 (0.5 μM), and a 3 log unit reduction was noted for Candida glabrata ATCC-15545 (1 μM). Infectivity was reduced by 6 log units in dengue 1 (0.1 μM), by 5 log units (0.5 μM) in vesicular stomatitis virus, and by 2 log units (5 μM) in human adenovirus-5. Overall, the results demonstrate that DIMPy-BODIPY exhibits antiviral, antibacterial and antifungal photodynamic inactivation at nanomolar concentrations and short illumination times. |
| first_indexed | 2024-04-13T23:33:48Z |
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| id | doaj.art-e2c16c43993e440e9db01ab81bbb36aa |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-13T23:33:48Z |
| publishDate | 2015-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e2c16c43993e440e9db01ab81bbb36aa2022-12-22T02:24:49ZengMDPI AGMolecules1420-30492015-06-01206106041062110.3390/molecules200610604molecules200610604Antiviral, Antifungal and Antibacterial Activities of a BODIPY-Based PhotosensitizerBradley L. Carpenter0Xingci Situ1Frank Scholle2Juergen Bartelmess3Walter W. Weare4Reza A. Ghiladi5Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8204, USADepartment of Chemistry, North Carolina State University, Raleigh, NC 27695-8204, USADepartment of Biological Sciences, North Carolina State University, Raleigh, NC 27695-7614, USADepartment of Chemistry, North Carolina State University, Raleigh, NC 27695-8204, USADepartment of Chemistry, North Carolina State University, Raleigh, NC 27695-8204, USADepartment of Chemistry, North Carolina State University, Raleigh, NC 27695-8204, USAAntimicrobial photodynamic inactivation (aPDI) employing the BODIPY-based photosensitizer 2,6-diiodo-1,3,5,7-tetramethyl-8-(N-methyl-4-pyridyl)-4,4′-difluoro-boradiazaindacene (DIMPy-BODIPY) was explored in an in vitro assay against six species of bacteria (eight total strains), three species of yeast, and three viruses as a complementary approach to their current drug-based or non-existent treatments. Our best results achieved a noteworthy 5–6 log unit reduction in CFU at 0.1 μM for Staphylococcus aureus (ATCC-2913), methicillin-resistant S. aureus (ATCC-44), and vancomycin-resistant Enterococcus faecium (ATCC-2320), a 4–5 log unit reduction for Acinetobacter baumannii ATCC-19606 (0.25 μM), multidrug resistant A. baumannii ATCC-1605 (0.1 μM), Pseudomonas aeruginosa ATCC-97 (0.5 μM), and Klebsiella pneumoniae ATCC-2146 (1 μM), and a 3 log unit reduction for Mycobacterium smegmatis mc2155 (ATCC-700084). A 5 log unit reduction in CFU was observed for Candida albicans ATCC-90028 (1 μM) and Cryptococcus neoformans ATCC-64538 (0.5 μM), and a 3 log unit reduction was noted for Candida glabrata ATCC-15545 (1 μM). Infectivity was reduced by 6 log units in dengue 1 (0.1 μM), by 5 log units (0.5 μM) in vesicular stomatitis virus, and by 2 log units (5 μM) in human adenovirus-5. Overall, the results demonstrate that DIMPy-BODIPY exhibits antiviral, antibacterial and antifungal photodynamic inactivation at nanomolar concentrations and short illumination times.http://www.mdpi.com/1420-3049/20/6/10604photodynamic therapysinglet oxygenantibacterialantiviralantifungalphotobiocidal |
| spellingShingle | Bradley L. Carpenter Xingci Situ Frank Scholle Juergen Bartelmess Walter W. Weare Reza A. Ghiladi Antiviral, Antifungal and Antibacterial Activities of a BODIPY-Based Photosensitizer Molecules photodynamic therapy singlet oxygen antibacterial antiviral antifungal photobiocidal |
| title | Antiviral, Antifungal and Antibacterial Activities of a BODIPY-Based Photosensitizer |
| title_full | Antiviral, Antifungal and Antibacterial Activities of a BODIPY-Based Photosensitizer |
| title_fullStr | Antiviral, Antifungal and Antibacterial Activities of a BODIPY-Based Photosensitizer |
| title_full_unstemmed | Antiviral, Antifungal and Antibacterial Activities of a BODIPY-Based Photosensitizer |
| title_short | Antiviral, Antifungal and Antibacterial Activities of a BODIPY-Based Photosensitizer |
| title_sort | antiviral antifungal and antibacterial activities of a bodipy based photosensitizer |
| topic | photodynamic therapy singlet oxygen antibacterial antiviral antifungal photobiocidal |
| url | http://www.mdpi.com/1420-3049/20/6/10604 |
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