Is there a relationship between metformin-related gastrointestinal symptoms and vitamin B12 deficiency in patients with type 2 diabetes mellitus?
Metformin (MTF) associated gastrointestinal symptoms are fairly common side effects that adversely affect patients' treatment adherence. However, the variability of gastrointestinal symptoms in MTF-using patients has not been fully explained. In our study, we aimed to investigate the relati...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Society of Turaz Bilim
2023-03-01
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| Series: | Medicine Science |
| Subjects: | |
| Online Access: | https://www.medicinescience.org/?mno=143332 |
| _version_ | 1797316489470017536 |
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| author | Fatih Eskin Duygu Tutan |
| author_facet | Fatih Eskin Duygu Tutan |
| author_sort | Fatih Eskin |
| collection | DOAJ |
| description | Metformin (MTF) associated gastrointestinal symptoms are fairly common side effects that adversely affect patients' treatment adherence. However, the variability of gastrointestinal symptoms in MTF-using patients has not been fully explained. In our study, we aimed to investigate the relationship between vitamin B12 deficiency with MTF-related gastrointestinal symptoms. Patients with type 2 diabetes mellitus (T2DM) using MTF were included in the study sequentially. Demographic characteristics of the patients, duration of diabetes, MTF dose and duration used, and gastrointestinal symptoms were recorded. Afterward, a hemogram, HgbA1c, and vitamin B12 measurements were performed. Patients with and without vitamin B12 deficiency were divided into two groups. The two groups were compared with statistical methods. Twenty-five percent of patients had low serum vitamin B12 levels. Patients with vitamin B12 deficiency had a longer diabetes duration, and a longer MTF usage duration (p [Med-Science 2023; 12(1.000): 324-31] |
| first_indexed | 2024-03-08T03:20:07Z |
| format | Article |
| id | doaj.art-e2c37bf9ee9c468295bbea060b308b56 |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T03:20:07Z |
| publishDate | 2023-03-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-e2c37bf9ee9c468295bbea060b308b562024-02-12T10:34:08ZengSociety of Turaz BilimMedicine Science2147-06342023-03-011213243110.5455/medscience.2023.02.025143332Is there a relationship between metformin-related gastrointestinal symptoms and vitamin B12 deficiency in patients with type 2 diabetes mellitus?Fatih Eskin0Duygu Tutan1Hitit University Faculty of Medicine, Departments of Internal Medicine, Corum, Erol Olcok Training and Research Hospital of Hitit University, Departments of Internal Medicine, Corum, TurkeyMetformin (MTF) associated gastrointestinal symptoms are fairly common side effects that adversely affect patients' treatment adherence. However, the variability of gastrointestinal symptoms in MTF-using patients has not been fully explained. In our study, we aimed to investigate the relationship between vitamin B12 deficiency with MTF-related gastrointestinal symptoms. Patients with type 2 diabetes mellitus (T2DM) using MTF were included in the study sequentially. Demographic characteristics of the patients, duration of diabetes, MTF dose and duration used, and gastrointestinal symptoms were recorded. Afterward, a hemogram, HgbA1c, and vitamin B12 measurements were performed. Patients with and without vitamin B12 deficiency were divided into two groups. The two groups were compared with statistical methods. Twenty-five percent of patients had low serum vitamin B12 levels. Patients with vitamin B12 deficiency had a longer diabetes duration, and a longer MTF usage duration (p [Med-Science 2023; 12(1.000): 324-31]https://www.medicinescience.org/?mno=143332diabetes mellitusgastrointestinal symptomsmetforminvitamin b12 deficiency |
| spellingShingle | Fatih Eskin Duygu Tutan Is there a relationship between metformin-related gastrointestinal symptoms and vitamin B12 deficiency in patients with type 2 diabetes mellitus? Medicine Science diabetes mellitus gastrointestinal symptoms metformin vitamin b12 deficiency |
| title | Is there a relationship between metformin-related gastrointestinal symptoms and vitamin B12 deficiency in patients with type 2 diabetes mellitus? |
| title_full | Is there a relationship between metformin-related gastrointestinal symptoms and vitamin B12 deficiency in patients with type 2 diabetes mellitus? |
| title_fullStr | Is there a relationship between metformin-related gastrointestinal symptoms and vitamin B12 deficiency in patients with type 2 diabetes mellitus? |
| title_full_unstemmed | Is there a relationship between metformin-related gastrointestinal symptoms and vitamin B12 deficiency in patients with type 2 diabetes mellitus? |
| title_short | Is there a relationship between metformin-related gastrointestinal symptoms and vitamin B12 deficiency in patients with type 2 diabetes mellitus? |
| title_sort | is there a relationship between metformin related gastrointestinal symptoms and vitamin b12 deficiency in patients with type 2 diabetes mellitus |
| topic | diabetes mellitus gastrointestinal symptoms metformin vitamin b12 deficiency |
| url | https://www.medicinescience.org/?mno=143332 |
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