The causal relationship between thoracic aortic aneurysm and immune cells: a mendelian randomization study
Abstract One of the pathogenic causes of thoracic aortic aneurysm (TAA), a dangerous vascular condition that can cause aortic rupture, is autoimmune disorders. Currently, immune cell clustering is becoming more and more refined, and the specific immune cell phenotypes involved are yet unknown. Here,...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-04-01
|
| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-024-03876-1 |
| _version_ | 1827277385437806592 |
|---|---|
| author | Guoli Liu Sha Pan Hongli Xia Mincai Li Ansen Wu |
| author_facet | Guoli Liu Sha Pan Hongli Xia Mincai Li Ansen Wu |
| author_sort | Guoli Liu |
| collection | DOAJ |
| description | Abstract One of the pathogenic causes of thoracic aortic aneurysm (TAA), a dangerous vascular condition that can cause aortic rupture, is autoimmune disorders. Currently, immune cell clustering is becoming more and more refined, and the specific immune cell phenotypes involved are yet unknown. Here, we want to clarify the causal link between TAA risk and 731 immune cell traits. There was a Mendelian randomization analysis (MR). We discovered that the presence of TAA led to an increase in CD45 on CD33− HLA-DR− myeloid cells, an increase in CD45 on natural killer cells, and a decrease in FSC-A on granulocytes after applying FDR correction. Our research also revealed a strong correlation between the incidence of TAA and an increase in immune cells with CD3 on CD39+ CD4+, and CD25 on IgD− CD27− phenotypes. Through genetic techniques, our research has shown the intimate relationship between immune cells and TAA, offering direction for future clinical investigations. |
| first_indexed | 2024-04-24T07:20:12Z |
| format | Article |
| id | doaj.art-e2c412623440401a85376d49054d1016 |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-04-24T07:20:12Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-e2c412623440401a85376d49054d10162024-04-21T11:07:59ZengBMCBMC Cardiovascular Disorders1471-22612024-04-012411610.1186/s12872-024-03876-1The causal relationship between thoracic aortic aneurysm and immune cells: a mendelian randomization studyGuoli Liu0Sha Pan1Hongli Xia2Mincai Li3Ansen Wu4Deparment of Vascular surgery, Xianning Central Hospital, the First Affiliated Hospital of Hubei University of Science and TechnologyDepartment of Neonatology, Xianning Central Hospital, the First Affiliated Hospital of Hubei University of Science and TechnologyDeparment of Vascular surgery, Xianning Central Hospital, the First Affiliated Hospital of Hubei University of Science and TechnologyHubei University of Science and TechnologyDeparment of Vascular surgery, Xianning Central Hospital, the First Affiliated Hospital of Hubei University of Science and TechnologyAbstract One of the pathogenic causes of thoracic aortic aneurysm (TAA), a dangerous vascular condition that can cause aortic rupture, is autoimmune disorders. Currently, immune cell clustering is becoming more and more refined, and the specific immune cell phenotypes involved are yet unknown. Here, we want to clarify the causal link between TAA risk and 731 immune cell traits. There was a Mendelian randomization analysis (MR). We discovered that the presence of TAA led to an increase in CD45 on CD33− HLA-DR− myeloid cells, an increase in CD45 on natural killer cells, and a decrease in FSC-A on granulocytes after applying FDR correction. Our research also revealed a strong correlation between the incidence of TAA and an increase in immune cells with CD3 on CD39+ CD4+, and CD25 on IgD− CD27− phenotypes. Through genetic techniques, our research has shown the intimate relationship between immune cells and TAA, offering direction for future clinical investigations.https://doi.org/10.1186/s12872-024-03876-1Mendelian randomizationThoracic aortic aneurysmGenome-wide association studyImmune cellsThe causal link |
| spellingShingle | Guoli Liu Sha Pan Hongli Xia Mincai Li Ansen Wu The causal relationship between thoracic aortic aneurysm and immune cells: a mendelian randomization study BMC Cardiovascular Disorders Mendelian randomization Thoracic aortic aneurysm Genome-wide association study Immune cells The causal link |
| title | The causal relationship between thoracic aortic aneurysm and immune cells: a mendelian randomization study |
| title_full | The causal relationship between thoracic aortic aneurysm and immune cells: a mendelian randomization study |
| title_fullStr | The causal relationship between thoracic aortic aneurysm and immune cells: a mendelian randomization study |
| title_full_unstemmed | The causal relationship between thoracic aortic aneurysm and immune cells: a mendelian randomization study |
| title_short | The causal relationship between thoracic aortic aneurysm and immune cells: a mendelian randomization study |
| title_sort | causal relationship between thoracic aortic aneurysm and immune cells a mendelian randomization study |
| topic | Mendelian randomization Thoracic aortic aneurysm Genome-wide association study Immune cells The causal link |
| url | https://doi.org/10.1186/s12872-024-03876-1 |
| work_keys_str_mv | AT guoliliu thecausalrelationshipbetweenthoracicaorticaneurysmandimmunecellsamendelianrandomizationstudy AT shapan thecausalrelationshipbetweenthoracicaorticaneurysmandimmunecellsamendelianrandomizationstudy AT honglixia thecausalrelationshipbetweenthoracicaorticaneurysmandimmunecellsamendelianrandomizationstudy AT mincaili thecausalrelationshipbetweenthoracicaorticaneurysmandimmunecellsamendelianrandomizationstudy AT ansenwu thecausalrelationshipbetweenthoracicaorticaneurysmandimmunecellsamendelianrandomizationstudy AT guoliliu causalrelationshipbetweenthoracicaorticaneurysmandimmunecellsamendelianrandomizationstudy AT shapan causalrelationshipbetweenthoracicaorticaneurysmandimmunecellsamendelianrandomizationstudy AT honglixia causalrelationshipbetweenthoracicaorticaneurysmandimmunecellsamendelianrandomizationstudy AT mincaili causalrelationshipbetweenthoracicaorticaneurysmandimmunecellsamendelianrandomizationstudy AT ansenwu causalrelationshipbetweenthoracicaorticaneurysmandimmunecellsamendelianrandomizationstudy |