Prospects for chimeric antigen receptor-modified T cell therapy for solid tumors
Abstract The potential for adoptive cell immunotherapy as a treatment against cancers has been demonstrated by the remarkable response in some patients with hematological malignancies using autologous T cells endowed with chimeric antigen receptors (CARs) specific for CD19. Clinical efficacy of CAR-...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-01-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12943-018-0759-3 |
| _version_ | 1828406614787358720 |
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| author | Erhao Zhang Jieyi Gu Hanmei Xu |
| author_facet | Erhao Zhang Jieyi Gu Hanmei Xu |
| author_sort | Erhao Zhang |
| collection | DOAJ |
| description | Abstract The potential for adoptive cell immunotherapy as a treatment against cancers has been demonstrated by the remarkable response in some patients with hematological malignancies using autologous T cells endowed with chimeric antigen receptors (CARs) specific for CD19. Clinical efficacy of CAR-T cell therapy for the treatment of solid tumors, however, is rare due to physical and biochemical factors. This review focuses on different aspects of multiple mechanisms of immunosuppression in solid tumors. We characterize the current state of CAR-modified T cell therapy and summarize the various strategies to combat the immunosuppressive microenvironment of solid tumors, with the aim of promoting T cell cytotoxicity and enhancing tumor cell eradication. |
| first_indexed | 2024-12-10T11:14:17Z |
| format | Article |
| id | doaj.art-e2c52db2d16e4d5badc4e0581d3777a1 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-10T11:14:17Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-e2c52db2d16e4d5badc4e0581d3777a12022-12-22T01:51:17ZengBMCMolecular Cancer1476-45982018-01-0117111210.1186/s12943-018-0759-3Prospects for chimeric antigen receptor-modified T cell therapy for solid tumorsErhao Zhang0Jieyi Gu1Hanmei Xu2The Engineering Research Center of Peptide Drug Discovery and Development, China Pharmaceutical UniversityThe Engineering Research Center of Peptide Drug Discovery and Development, China Pharmaceutical UniversityThe Engineering Research Center of Peptide Drug Discovery and Development, China Pharmaceutical UniversityAbstract The potential for adoptive cell immunotherapy as a treatment against cancers has been demonstrated by the remarkable response in some patients with hematological malignancies using autologous T cells endowed with chimeric antigen receptors (CARs) specific for CD19. Clinical efficacy of CAR-T cell therapy for the treatment of solid tumors, however, is rare due to physical and biochemical factors. This review focuses on different aspects of multiple mechanisms of immunosuppression in solid tumors. We characterize the current state of CAR-modified T cell therapy and summarize the various strategies to combat the immunosuppressive microenvironment of solid tumors, with the aim of promoting T cell cytotoxicity and enhancing tumor cell eradication.http://link.springer.com/article/10.1186/s12943-018-0759-3Chimeric antigen receptor T cellAdoptive cell therapySolid tumorImmunosuppressive microenvironmentCancer immunotherapy |
| spellingShingle | Erhao Zhang Jieyi Gu Hanmei Xu Prospects for chimeric antigen receptor-modified T cell therapy for solid tumors Molecular Cancer Chimeric antigen receptor T cell Adoptive cell therapy Solid tumor Immunosuppressive microenvironment Cancer immunotherapy |
| title | Prospects for chimeric antigen receptor-modified T cell therapy for solid tumors |
| title_full | Prospects for chimeric antigen receptor-modified T cell therapy for solid tumors |
| title_fullStr | Prospects for chimeric antigen receptor-modified T cell therapy for solid tumors |
| title_full_unstemmed | Prospects for chimeric antigen receptor-modified T cell therapy for solid tumors |
| title_short | Prospects for chimeric antigen receptor-modified T cell therapy for solid tumors |
| title_sort | prospects for chimeric antigen receptor modified t cell therapy for solid tumors |
| topic | Chimeric antigen receptor T cell Adoptive cell therapy Solid tumor Immunosuppressive microenvironment Cancer immunotherapy |
| url | http://link.springer.com/article/10.1186/s12943-018-0759-3 |
| work_keys_str_mv | AT erhaozhang prospectsforchimericantigenreceptormodifiedtcelltherapyforsolidtumors AT jieyigu prospectsforchimericantigenreceptormodifiedtcelltherapyforsolidtumors AT hanmeixu prospectsforchimericantigenreceptormodifiedtcelltherapyforsolidtumors |