Parameters of Oxidative and Inflammatory Status in a Three-Month Observation of Patients with Acute Myocardial Infarction Undergoing Coronary Angioplasty—A Preliminary Study
<i>Background and Objectives</i>: Patients with acute myocardial infarction (MI) are usually treated with percutaneous transluminal coronary angioplasty (PTCA), which is burdened with a risk of postoperative complications, often accompanied by biochemical disturbances. The aim of our stu...
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| Format: | Article |
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MDPI AG
2019-09-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/55/9/585 |
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| author | Ewa Żurawska-Płaksej Sylwia Płaczkowska Lilla Pawlik-Sobecka Hanna Czapor-Irzabek Aneta Stachurska Andrzej Mysiak Tadeusz Sebzda Jakub Gburek Agnieszka Piwowar |
| author_facet | Ewa Żurawska-Płaksej Sylwia Płaczkowska Lilla Pawlik-Sobecka Hanna Czapor-Irzabek Aneta Stachurska Andrzej Mysiak Tadeusz Sebzda Jakub Gburek Agnieszka Piwowar |
| author_sort | Ewa Żurawska-Płaksej |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Patients with acute myocardial infarction (MI) are usually treated with percutaneous transluminal coronary angioplasty (PTCA), which is burdened with a risk of postoperative complications, often accompanied by biochemical disturbances. The aim of our study was to evaluate a set of selected parameters of oxidative and inflammatory status, which could be useful in the management of post-procedural care in MI patients after PTCA. <i>Materials and Methods</i>: In this preliminary study, ischemia modified albumin (IMA), advanced oxidation protein products (AOPP), thiol groups (SH), total antioxidant status (TAS), insulin growth factor-1 (IGF-1), presepsin (PSP), and trimethylamine N-oxide (TMAO) were chosen as candidate biomarkers, and were determined in patients with MI who underwent PTCA at two time points: During cardiac episodes (at admission to the hospital, T0) and 3 months later (T3). <i>Results</i>: Most of the examined parameters were significantly different between patients and control subjects (except for IMA and TAS), but only hsCRP changed significantly during the time of observation (T0 vs. T3). Discriminant analysis created a model composed of AOPP, hsCRP, PSP, and TMAO, which differentiated male subjects into a group with MI and a control (without cardiovascular diseases). <i>Conclusion</i>: This set of parameters seems useful in evaluating inflammatory and oxidative status in MI patients after PTCA. |
| first_indexed | 2024-03-12T06:14:10Z |
| format | Article |
| id | doaj.art-e2c5e17d1a584bdc9d2e2baee13bab75 |
| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T06:14:10Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-e2c5e17d1a584bdc9d2e2baee13bab752023-09-03T02:47:31ZengMDPI AGMedicina1010-660X2019-09-0155958510.3390/medicina55090585medicina55090585Parameters of Oxidative and Inflammatory Status in a Three-Month Observation of Patients with Acute Myocardial Infarction Undergoing Coronary Angioplasty—A Preliminary StudyEwa Żurawska-Płaksej0Sylwia Płaczkowska1Lilla Pawlik-Sobecka2Hanna Czapor-Irzabek3Aneta Stachurska4Andrzej Mysiak5Tadeusz Sebzda6Jakub Gburek7Agnieszka Piwowar8Department of Pharmaceutical Biochemistry, Wroclaw Medical University, 50-556 Wroclaw, PolandDiagnostics Laboratory for Teaching and Research, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Laboratory Diagnostics, Wroclaw Medical University, 50-556 Wroclaw, PolandLaboratory of Elemental Analysis and Structural Research, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment and Clinic of Cardiology, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment and Clinic of Cardiology, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Pathophysiology, Wroclaw Medical University, 50-368 Wroclaw, PolandDepartment of Pharmaceutical Biochemistry, Wroclaw Medical University, 50-556 Wroclaw, PolandDepartment of Toxicology, Wroclaw Medical University, 50-556 Wroclaw, Poland<i>Background and Objectives</i>: Patients with acute myocardial infarction (MI) are usually treated with percutaneous transluminal coronary angioplasty (PTCA), which is burdened with a risk of postoperative complications, often accompanied by biochemical disturbances. The aim of our study was to evaluate a set of selected parameters of oxidative and inflammatory status, which could be useful in the management of post-procedural care in MI patients after PTCA. <i>Materials and Methods</i>: In this preliminary study, ischemia modified albumin (IMA), advanced oxidation protein products (AOPP), thiol groups (SH), total antioxidant status (TAS), insulin growth factor-1 (IGF-1), presepsin (PSP), and trimethylamine N-oxide (TMAO) were chosen as candidate biomarkers, and were determined in patients with MI who underwent PTCA at two time points: During cardiac episodes (at admission to the hospital, T0) and 3 months later (T3). <i>Results</i>: Most of the examined parameters were significantly different between patients and control subjects (except for IMA and TAS), but only hsCRP changed significantly during the time of observation (T0 vs. T3). Discriminant analysis created a model composed of AOPP, hsCRP, PSP, and TMAO, which differentiated male subjects into a group with MI and a control (without cardiovascular diseases). <i>Conclusion</i>: This set of parameters seems useful in evaluating inflammatory and oxidative status in MI patients after PTCA.https://www.mdpi.com/1010-660X/55/9/585percutaneous coronary interventionoxidative stresspresepsintrimethylamine N-oxideinsulin-growth factor 1 |
| spellingShingle | Ewa Żurawska-Płaksej Sylwia Płaczkowska Lilla Pawlik-Sobecka Hanna Czapor-Irzabek Aneta Stachurska Andrzej Mysiak Tadeusz Sebzda Jakub Gburek Agnieszka Piwowar Parameters of Oxidative and Inflammatory Status in a Three-Month Observation of Patients with Acute Myocardial Infarction Undergoing Coronary Angioplasty—A Preliminary Study Medicina percutaneous coronary intervention oxidative stress presepsin trimethylamine N-oxide insulin-growth factor 1 |
| title | Parameters of Oxidative and Inflammatory Status in a Three-Month Observation of Patients with Acute Myocardial Infarction Undergoing Coronary Angioplasty—A Preliminary Study |
| title_full | Parameters of Oxidative and Inflammatory Status in a Three-Month Observation of Patients with Acute Myocardial Infarction Undergoing Coronary Angioplasty—A Preliminary Study |
| title_fullStr | Parameters of Oxidative and Inflammatory Status in a Three-Month Observation of Patients with Acute Myocardial Infarction Undergoing Coronary Angioplasty—A Preliminary Study |
| title_full_unstemmed | Parameters of Oxidative and Inflammatory Status in a Three-Month Observation of Patients with Acute Myocardial Infarction Undergoing Coronary Angioplasty—A Preliminary Study |
| title_short | Parameters of Oxidative and Inflammatory Status in a Three-Month Observation of Patients with Acute Myocardial Infarction Undergoing Coronary Angioplasty—A Preliminary Study |
| title_sort | parameters of oxidative and inflammatory status in a three month observation of patients with acute myocardial infarction undergoing coronary angioplasty a preliminary study |
| topic | percutaneous coronary intervention oxidative stress presepsin trimethylamine N-oxide insulin-growth factor 1 |
| url | https://www.mdpi.com/1010-660X/55/9/585 |
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