Association of quality of life with structural, functional and molecular brain imaging in community-dwelling older adults
Background: As the population ages, maintaining mental health and well-being of older adults is a public health priority. Beyond objective measures of health, self-perceived quality of life (QoL) is a good indicator of successful aging. In older adults, it has been shown that QoL is related to struc...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-05-01
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| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811921000963 |
| _version_ | 1819090336328187904 |
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| author | Valentin Ourry Julie Gonneaud Brigitte Landeau Inès Moulinet Edelweiss Touron Sophie Dautricourt Gwendoline Le Du Florence Mézenge Claire André Alexandre Bejanin Siya Sherif Natalie L. Marchant Léo Paly Géraldine Poisnel Denis Vivien Anne Chocat Anne Quillard Eglantine Ferrand Devouge Vincent de la Sayette Géraldine Rauchs Eider M. Arenaza-Urquijo Gaël Chételat |
| author_facet | Valentin Ourry Julie Gonneaud Brigitte Landeau Inès Moulinet Edelweiss Touron Sophie Dautricourt Gwendoline Le Du Florence Mézenge Claire André Alexandre Bejanin Siya Sherif Natalie L. Marchant Léo Paly Géraldine Poisnel Denis Vivien Anne Chocat Anne Quillard Eglantine Ferrand Devouge Vincent de la Sayette Géraldine Rauchs Eider M. Arenaza-Urquijo Gaël Chételat |
| author_sort | Valentin Ourry |
| collection | DOAJ |
| description | Background: As the population ages, maintaining mental health and well-being of older adults is a public health priority. Beyond objective measures of health, self-perceived quality of life (QoL) is a good indicator of successful aging. In older adults, it has been shown that QoL is related to structural brain changes. However, QoL is a multi-faceted concept and little is known about the specific relationship of each QoL domain to brain structure, nor about the links with other aspects of brain integrity, including white matter microstructure, brain perfusion and amyloid deposition, which are particularly relevant in aging. Therefore, we aimed to better characterize the brain biomarkers associated with each QoL domain using a comprehensive multimodal neuroimaging approach in older adults. Methods: One hundred and thirty-five cognitively unimpaired older adults (mean age ± SD: 69.4 ± 3.8 y) underwent structural and diffusion magnetic resonance imaging, together with early and late florbetapir positron emission tomography scans. QoL was assessed using the brief version of the World Health Organization's QoL instrument, which allows measuring four distinct domains of QoL: self-perceived physical health, psychological health, social relationships and environment. Multiple regression analyses were carried out to identify the independent global neuroimaging predictor(s) of each QoL domain, and voxel-wise analyses were then conducted with the significant predictor(s) to highlight the brain regions involved. Age, sex, education and the other QoL domains were entered as covariates in these analyses. Finally, forward stepwise multiple regressions were conducted to determine the specific items of the relevant QoL domain(s) that contributed the most to these brain associations. Results: Only physical health QoL was associated with global neuroimaging values, specifically gray matter volume and white matter mean kurtosis, with higher physical health QoL being associated with greater brain integrity. These relationships were still significant after correction for objective physical health and physical activity measures. No association was found with global brain perfusion or global amyloid deposition. Voxel-wise analyses revealed that the relationships with physical health QoL concerned the anterior insula and ventrolateral prefrontal cortex, and the corpus callosum, corona radiata, inferior frontal white matter and cingulum. Self-perceived daily living activities and self-perceived pain and discomfort were the items that contributed the most to these associations with gray matter volume and white matter mean kurtosis, respectively. Conclusions: Better self-perceived physical health, encompassing daily living activities and pain and discomfort, was the only QoL domain related to brain structural integrity including higher global gray matter volume and global white matter microstructural integrity in cognitively unimpaired older adults. The relationships involved brain structures belonging to the salience network, the pain pathway and the empathy network. While previous studies showed a link between objective measures of physical health, our findings specifically highlight the relevance of monitoring and promoting self-perceived physical health in the older population. Longitudinal studies are needed to assess the direction and causality of the relationships between QoL and brain integrity. |
| first_indexed | 2024-12-21T22:22:12Z |
| format | Article |
| id | doaj.art-e2c6336959e84e3891e06d25902ecdc7 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-12-21T22:22:12Z |
| publishDate | 2021-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-e2c6336959e84e3891e06d25902ecdc72022-12-21T18:48:19ZengElsevierNeuroImage1095-95722021-05-01231117819Association of quality of life with structural, functional and molecular brain imaging in community-dwelling older adultsValentin Ourry0Julie Gonneaud1Brigitte Landeau2Inès Moulinet3Edelweiss Touron4Sophie Dautricourt5Gwendoline Le Du6Florence Mézenge7Claire André8Alexandre Bejanin9Siya Sherif10Natalie L. Marchant11Léo Paly12Géraldine Poisnel13Denis Vivien14Anne Chocat15Anne Quillard16Eglantine Ferrand Devouge17Vincent de la Sayette18Géraldine Rauchs19Eider M. Arenaza-Urquijo20Gaël Chételat21Normandie Univ, UNICAEN, INSERM, U1237, PhIND ''Physiopathology and Imaging of Neurological Disorders'', Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, France; Normandie Univ, UNICAEN, PSL Université, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, NIMH, Caen, FranceNormandie Univ, UNICAEN, INSERM, U1237, PhIND ''Physiopathology and Imaging of Neurological Disorders'', Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, FranceNormandie Univ, UNICAEN, INSERM, U1237, PhIND ''Physiopathology and Imaging of Neurological Disorders'', Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, FranceNormandie Univ, UNICAEN, INSERM, U1237, PhIND ''Physiopathology and Imaging of Neurological Disorders'', Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, FranceNormandie Univ, UNICAEN, INSERM, U1237, PhIND ''Physiopathology and Imaging of Neurological Disorders'', Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, FranceNormandie Univ, UNICAEN, INSERM, U1237, PhIND ''Physiopathology and Imaging of Neurological Disorders'', Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, FranceNormandie Univ, UNICAEN, INSERM, U1237, PhIND ''Physiopathology and Imaging of Neurological Disorders'', Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, FranceNormandie Univ, UNICAEN, INSERM, U1237, PhIND ''Physiopathology and Imaging of Neurological Disorders'', Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, FranceNormandie Univ, UNICAEN, INSERM, U1237, PhIND ''Physiopathology and Imaging of Neurological Disorders'', Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, France; Normandie Univ, UNICAEN, PSL Université, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, NIMH, Caen, FranceNormandie Univ, UNICAEN, INSERM, U1237, PhIND ''Physiopathology and Imaging of Neurological Disorders'', Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, FranceNormandie Univ, UNICAEN, INSERM, U1237, PhIND ''Physiopathology and Imaging of Neurological Disorders'', Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, FranceDivision of Psychiatry, University College London, London, United KingdomNormandie Univ, UNICAEN, INSERM, U1237, PhIND ''Physiopathology and Imaging of Neurological Disorders'', Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, FranceNormandie Univ, UNICAEN, INSERM, U1237, PhIND ''Physiopathology and Imaging of Neurological Disorders'', Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, FranceNormandie Univ, UNICAEN, INSERM, U1237, PhIND ''Physiopathology and Imaging of Neurological Disorders'', Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, France; Département de Recherche Clinique, CHU Caen-Normandie, Caen, France.Normandie Univ, UNICAEN, INSERM, U1237, PhIND ''Physiopathology and Imaging of Neurological Disorders'', Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, FranceNormandie Univ, UNICAEN, INSERM, U1237, PhIND ''Physiopathology and Imaging of Neurological Disorders'', Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, FranceNormandie Univ, UNICAEN, INSERM, U1237, PhIND ''Physiopathology and Imaging of Neurological Disorders'', Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, France; Normandie Univ, UNIROUEN, Department of General Practice, Rouen, France; Rouen University Hospital, CIC-CRB 1404, F 76000, Rouen, FranceNormandie Univ, UNICAEN, PSL Université, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, NIMH, Caen, France; Service de Neurologie, CHU de Caen, Caen, FranceNormandie Univ, UNICAEN, PSL Université, EPHE, INSERM, U1077, CHU de Caen, GIP Cyceron, NIMH, Caen, FranceNormandie Univ, UNICAEN, INSERM, U1237, PhIND ''Physiopathology and Imaging of Neurological Disorders'', Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, France; Barcelonabeta Brain Research Center, Fundación Pasqual Maragall, Barcelona, SpainNormandie Univ, UNICAEN, INSERM, U1237, PhIND ''Physiopathology and Imaging of Neurological Disorders'', Institut Blood and Brain @ Caen-Normandie, Cyceron, 14000 Caen, France; Corresponding author.Background: As the population ages, maintaining mental health and well-being of older adults is a public health priority. Beyond objective measures of health, self-perceived quality of life (QoL) is a good indicator of successful aging. In older adults, it has been shown that QoL is related to structural brain changes. However, QoL is a multi-faceted concept and little is known about the specific relationship of each QoL domain to brain structure, nor about the links with other aspects of brain integrity, including white matter microstructure, brain perfusion and amyloid deposition, which are particularly relevant in aging. Therefore, we aimed to better characterize the brain biomarkers associated with each QoL domain using a comprehensive multimodal neuroimaging approach in older adults. Methods: One hundred and thirty-five cognitively unimpaired older adults (mean age ± SD: 69.4 ± 3.8 y) underwent structural and diffusion magnetic resonance imaging, together with early and late florbetapir positron emission tomography scans. QoL was assessed using the brief version of the World Health Organization's QoL instrument, which allows measuring four distinct domains of QoL: self-perceived physical health, psychological health, social relationships and environment. Multiple regression analyses were carried out to identify the independent global neuroimaging predictor(s) of each QoL domain, and voxel-wise analyses were then conducted with the significant predictor(s) to highlight the brain regions involved. Age, sex, education and the other QoL domains were entered as covariates in these analyses. Finally, forward stepwise multiple regressions were conducted to determine the specific items of the relevant QoL domain(s) that contributed the most to these brain associations. Results: Only physical health QoL was associated with global neuroimaging values, specifically gray matter volume and white matter mean kurtosis, with higher physical health QoL being associated with greater brain integrity. These relationships were still significant after correction for objective physical health and physical activity measures. No association was found with global brain perfusion or global amyloid deposition. Voxel-wise analyses revealed that the relationships with physical health QoL concerned the anterior insula and ventrolateral prefrontal cortex, and the corpus callosum, corona radiata, inferior frontal white matter and cingulum. Self-perceived daily living activities and self-perceived pain and discomfort were the items that contributed the most to these associations with gray matter volume and white matter mean kurtosis, respectively. Conclusions: Better self-perceived physical health, encompassing daily living activities and pain and discomfort, was the only QoL domain related to brain structural integrity including higher global gray matter volume and global white matter microstructural integrity in cognitively unimpaired older adults. The relationships involved brain structures belonging to the salience network, the pain pathway and the empathy network. While previous studies showed a link between objective measures of physical health, our findings specifically highlight the relevance of monitoring and promoting self-perceived physical health in the older population. Longitudinal studies are needed to assess the direction and causality of the relationships between QoL and brain integrity.http://www.sciencedirect.com/science/article/pii/S1053811921000963Quality of lifeMultimodal neuroimagingNeurodegenerationWhite matter microstructureAmyloid imagingOlder adults |
| spellingShingle | Valentin Ourry Julie Gonneaud Brigitte Landeau Inès Moulinet Edelweiss Touron Sophie Dautricourt Gwendoline Le Du Florence Mézenge Claire André Alexandre Bejanin Siya Sherif Natalie L. Marchant Léo Paly Géraldine Poisnel Denis Vivien Anne Chocat Anne Quillard Eglantine Ferrand Devouge Vincent de la Sayette Géraldine Rauchs Eider M. Arenaza-Urquijo Gaël Chételat Association of quality of life with structural, functional and molecular brain imaging in community-dwelling older adults NeuroImage Quality of life Multimodal neuroimaging Neurodegeneration White matter microstructure Amyloid imaging Older adults |
| title | Association of quality of life with structural, functional and molecular brain imaging in community-dwelling older adults |
| title_full | Association of quality of life with structural, functional and molecular brain imaging in community-dwelling older adults |
| title_fullStr | Association of quality of life with structural, functional and molecular brain imaging in community-dwelling older adults |
| title_full_unstemmed | Association of quality of life with structural, functional and molecular brain imaging in community-dwelling older adults |
| title_short | Association of quality of life with structural, functional and molecular brain imaging in community-dwelling older adults |
| title_sort | association of quality of life with structural functional and molecular brain imaging in community dwelling older adults |
| topic | Quality of life Multimodal neuroimaging Neurodegeneration White matter microstructure Amyloid imaging Older adults |
| url | http://www.sciencedirect.com/science/article/pii/S1053811921000963 |
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