T Cells With Activated STAT4 Drive the High-Risk Rejection State to Renal Allograft Failure After Kidney Transplantation

T Cells With Activated STAT4 Drive the High-Risk Rejection State to Renal Allograft Failure After Kidney Transplantation

In kidney transplantation, deteriorated progression of rejection is considered to be a leading course of postoperative mortality. However, the conventional histologic diagnosis is limited in reading the rejection status at the molecular level, thereby triggering mismatched pathogenesis with clinical...

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Bibliographic Details
Main Authors: Yihan Chen, Bao Zhang, Tianliang Liu, Xiaoping Chen, Yaning Wang, Hongbo Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
kidney transplantation rejection
transcriptome-based re-classification
high-risk rejection
T cells
PTPN6-STAT4 signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.895762/full

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