Antiviral and Immunomodulatory Properties of Antimicrobial Peptides Produced by Human Keratinocytes
Keratinocytes, the main cells of the epidermis, are the first site of replication as well as the first line of defense against many viruses such as arboviruses, enteroviruses, herpes viruses, human papillomaviruses, or vaccinia virus. During viral replication, these cells can sense virus associated...
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Frontiers Media S.A.
2020-06-01
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Series: | Frontiers in Microbiology |
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Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2020.01155/full |
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author | Céline Chessa Céline Chessa Charles Bodet Clément Jousselin Clément Jousselin Michel Wehbe Nicolas Lévêque Nicolas Lévêque Magali Garcia Magali Garcia |
author_facet | Céline Chessa Céline Chessa Charles Bodet Clément Jousselin Clément Jousselin Michel Wehbe Nicolas Lévêque Nicolas Lévêque Magali Garcia Magali Garcia |
author_sort | Céline Chessa |
collection | DOAJ |
description | Keratinocytes, the main cells of the epidermis, are the first site of replication as well as the first line of defense against many viruses such as arboviruses, enteroviruses, herpes viruses, human papillomaviruses, or vaccinia virus. During viral replication, these cells can sense virus associated molecular patterns leading to the initiation of an innate immune response composed of pro-inflammatory cytokines, chemokines, and antimicrobial peptides. Human keratinocytes produce and secrete at least nine antimicrobial peptides: human cathelicidin LL-37, types 1–4 human β-defensins, S100 peptides such as psoriasin (S100A7), calprotectin (S100A8/9) and koebnerisin (S100A15), and RNase 7. These peptides can exert direct antiviral effects on the viral particle or its replication cycle, and indirect antiviral activity, by modulating the host immune response. The purpose of this review is to summarize current knowledge of antiviral and immunomodulatory properties of human keratinocyte antimicrobial peptides. |
first_indexed | 2024-04-12T09:07:41Z |
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id | doaj.art-e2c7e152d9a3458eb8cd64c584994310 |
institution | Directory Open Access Journal |
issn | 1664-302X |
language | English |
last_indexed | 2024-04-12T09:07:41Z |
publishDate | 2020-06-01 |
publisher | Frontiers Media S.A. |
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series | Frontiers in Microbiology |
spelling | doaj.art-e2c7e152d9a3458eb8cd64c5849943102022-12-22T03:39:04ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2020-06-011110.3389/fmicb.2020.01155501611Antiviral and Immunomodulatory Properties of Antimicrobial Peptides Produced by Human KeratinocytesCéline Chessa0Céline Chessa1Charles Bodet2Clément Jousselin3Clément Jousselin4Michel Wehbe5Nicolas Lévêque6Nicolas Lévêque7Magali Garcia8Magali Garcia9Laboratoire de Virologie et Mycobactériologie, CHU de Poitiers, Poitiers, FranceLaboratoire Inflammation, Tissus Epithéliaux et Cytokines, LITEC EA 4331, Université de Poitiers, Poitiers, FranceLaboratoire Inflammation, Tissus Epithéliaux et Cytokines, LITEC EA 4331, Université de Poitiers, Poitiers, FranceLaboratoire de Virologie et Mycobactériologie, CHU de Poitiers, Poitiers, FranceLaboratoire Inflammation, Tissus Epithéliaux et Cytokines, LITEC EA 4331, Université de Poitiers, Poitiers, FranceLaboratoire Inflammation, Tissus Epithéliaux et Cytokines, LITEC EA 4331, Université de Poitiers, Poitiers, FranceLaboratoire de Virologie et Mycobactériologie, CHU de Poitiers, Poitiers, FranceLaboratoire Inflammation, Tissus Epithéliaux et Cytokines, LITEC EA 4331, Université de Poitiers, Poitiers, FranceLaboratoire de Virologie et Mycobactériologie, CHU de Poitiers, Poitiers, FranceLaboratoire Inflammation, Tissus Epithéliaux et Cytokines, LITEC EA 4331, Université de Poitiers, Poitiers, FranceKeratinocytes, the main cells of the epidermis, are the first site of replication as well as the first line of defense against many viruses such as arboviruses, enteroviruses, herpes viruses, human papillomaviruses, or vaccinia virus. During viral replication, these cells can sense virus associated molecular patterns leading to the initiation of an innate immune response composed of pro-inflammatory cytokines, chemokines, and antimicrobial peptides. Human keratinocytes produce and secrete at least nine antimicrobial peptides: human cathelicidin LL-37, types 1–4 human β-defensins, S100 peptides such as psoriasin (S100A7), calprotectin (S100A8/9) and koebnerisin (S100A15), and RNase 7. These peptides can exert direct antiviral effects on the viral particle or its replication cycle, and indirect antiviral activity, by modulating the host immune response. The purpose of this review is to summarize current knowledge of antiviral and immunomodulatory properties of human keratinocyte antimicrobial peptides.https://www.frontiersin.org/article/10.3389/fmicb.2020.01155/fullkeratinocyteantimicrobial peptideinnate immunityantiviralimmunomodulation |
spellingShingle | Céline Chessa Céline Chessa Charles Bodet Clément Jousselin Clément Jousselin Michel Wehbe Nicolas Lévêque Nicolas Lévêque Magali Garcia Magali Garcia Antiviral and Immunomodulatory Properties of Antimicrobial Peptides Produced by Human Keratinocytes Frontiers in Microbiology keratinocyte antimicrobial peptide innate immunity antiviral immunomodulation |
title | Antiviral and Immunomodulatory Properties of Antimicrobial Peptides Produced by Human Keratinocytes |
title_full | Antiviral and Immunomodulatory Properties of Antimicrobial Peptides Produced by Human Keratinocytes |
title_fullStr | Antiviral and Immunomodulatory Properties of Antimicrobial Peptides Produced by Human Keratinocytes |
title_full_unstemmed | Antiviral and Immunomodulatory Properties of Antimicrobial Peptides Produced by Human Keratinocytes |
title_short | Antiviral and Immunomodulatory Properties of Antimicrobial Peptides Produced by Human Keratinocytes |
title_sort | antiviral and immunomodulatory properties of antimicrobial peptides produced by human keratinocytes |
topic | keratinocyte antimicrobial peptide innate immunity antiviral immunomodulation |
url | https://www.frontiersin.org/article/10.3389/fmicb.2020.01155/full |
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