Non-cirrhotic portal hypertension related to azathioprine therapy in a patient with Crohn’s disease
Azathioprine is widely used for the treatment of Crohn’s disease (CD). Few cases from Western countries have reported idiopathic non-cirrhotic portal hypertension (NCPH) related to thiopurine therapy in patients with inflammatory bowel disease. Idiopathic NCPH is a rare hepatic condition with intrah...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of Intestinal Diseases
2021-04-01
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| Series: | Intestinal Research |
| Subjects: | |
| Online Access: | http://www.irjournal.org/upload/pdf/ir-2020-00016.pdf |
| _version_ | 1818720668536012800 |
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| author | Jong Won Seo Eun Soo Kim Man-Hoon Han Young Oh Kweon |
| author_facet | Jong Won Seo Eun Soo Kim Man-Hoon Han Young Oh Kweon |
| author_sort | Jong Won Seo |
| collection | DOAJ |
| description | Azathioprine is widely used for the treatment of Crohn’s disease (CD). Few cases from Western countries have reported idiopathic non-cirrhotic portal hypertension (NCPH) related to thiopurine therapy in patients with inflammatory bowel disease. Idiopathic NCPH is a rare hepatic condition with intrahepatic portal hypertension but no evidence of cirrhosis or chronic liver disease. Patients with idiopathic NCPH present with symptoms of portal hypertension such as thrombocytopenia, splenomegaly and esophageal varices. We report a case of idiopathic NCPH in a 51-year-old male patient with CD who had been taking azathioprine for 5 years. He was admitted due to esophageal variceal bleeding along with splenomegaly and thrombocytopenia. Evaluation of cirrhosis or chronic liver disease showed normal-range results as estimated by FibroScan evaluation, laboratory examination for autoimmune hepatitis or viral hepatitis, and liver biopsy. This case may suggest the need for careful monitoring for manifestations of portal hypertension in Asian patients with inflammatory bowel disease receiving thiopurine treatment. |
| first_indexed | 2024-12-17T20:26:30Z |
| format | Article |
| id | doaj.art-e2c967d4573a4019b197c57ba95cf6a6 |
| institution | Directory Open Access Journal |
| issn | 1598-9100 2288-1956 |
| language | English |
| last_indexed | 2024-12-17T20:26:30Z |
| publishDate | 2021-04-01 |
| publisher | Korean Association for the Study of Intestinal Diseases |
| record_format | Article |
| series | Intestinal Research |
| spelling | doaj.art-e2c967d4573a4019b197c57ba95cf6a62022-12-21T21:33:46ZengKorean Association for the Study of Intestinal DiseasesIntestinal Research1598-91002288-19562021-04-0119224725110.5217/ir.2020.00016852Non-cirrhotic portal hypertension related to azathioprine therapy in a patient with Crohn’s diseaseJong Won Seo0Eun Soo Kim1Man-Hoon Han2Young Oh Kweon3 Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea Department of Pathology, School of Medicine, Kyungpook National University, Daegu, Korea Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, KoreaAzathioprine is widely used for the treatment of Crohn’s disease (CD). Few cases from Western countries have reported idiopathic non-cirrhotic portal hypertension (NCPH) related to thiopurine therapy in patients with inflammatory bowel disease. Idiopathic NCPH is a rare hepatic condition with intrahepatic portal hypertension but no evidence of cirrhosis or chronic liver disease. Patients with idiopathic NCPH present with symptoms of portal hypertension such as thrombocytopenia, splenomegaly and esophageal varices. We report a case of idiopathic NCPH in a 51-year-old male patient with CD who had been taking azathioprine for 5 years. He was admitted due to esophageal variceal bleeding along with splenomegaly and thrombocytopenia. Evaluation of cirrhosis or chronic liver disease showed normal-range results as estimated by FibroScan evaluation, laboratory examination for autoimmune hepatitis or viral hepatitis, and liver biopsy. This case may suggest the need for careful monitoring for manifestations of portal hypertension in Asian patients with inflammatory bowel disease receiving thiopurine treatment.http://www.irjournal.org/upload/pdf/ir-2020-00016.pdfcrohn diseaseazathioprinenon-cirrhotic portal hypertension |
| spellingShingle | Jong Won Seo Eun Soo Kim Man-Hoon Han Young Oh Kweon Non-cirrhotic portal hypertension related to azathioprine therapy in a patient with Crohn’s disease Intestinal Research crohn disease azathioprine non-cirrhotic portal hypertension |
| title | Non-cirrhotic portal hypertension related to azathioprine therapy in a patient with Crohn’s disease |
| title_full | Non-cirrhotic portal hypertension related to azathioprine therapy in a patient with Crohn’s disease |
| title_fullStr | Non-cirrhotic portal hypertension related to azathioprine therapy in a patient with Crohn’s disease |
| title_full_unstemmed | Non-cirrhotic portal hypertension related to azathioprine therapy in a patient with Crohn’s disease |
| title_short | Non-cirrhotic portal hypertension related to azathioprine therapy in a patient with Crohn’s disease |
| title_sort | non cirrhotic portal hypertension related to azathioprine therapy in a patient with crohn s disease |
| topic | crohn disease azathioprine non-cirrhotic portal hypertension |
| url | http://www.irjournal.org/upload/pdf/ir-2020-00016.pdf |
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