Differences in Salivary Proteins as a Function of PROP Taster Status and Gender in Normal Weight and Obese Subjects
Taste plays an important role in processes such as food choices, nutrition status and health. Salivary proteins contribute to taste sensitivity. Taste reduction has been associated with obesity. Gender influences the obesity predisposition and the genetic ability to perceive the bitterness of 6-<...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/8/2244 |
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| author | Melania Melis Mariano Mastinu Stefano Pintus Tiziana Cabras Roberto Crnjar Iole Tomassini Barbarossa |
| author_facet | Melania Melis Mariano Mastinu Stefano Pintus Tiziana Cabras Roberto Crnjar Iole Tomassini Barbarossa |
| author_sort | Melania Melis |
| collection | DOAJ |
| description | Taste plays an important role in processes such as food choices, nutrition status and health. Salivary proteins contribute to taste sensitivity. Taste reduction has been associated with obesity. Gender influences the obesity predisposition and the genetic ability to perceive the bitterness of 6-<i>n</i>-propylthiouracil (PROP), oral marker for food preferences and consumption. We investigated variations in the profile of salivary proteome, analyzed by HPLC-ESI-MS, between sixty-one normal weight subjects (NW) and fifty-seven subjects with obesity (OB), based on gender and PROP sensitivity. Results showed variations of taste-related salivary proteins between NW and OB, which were differently associated with gender and PROP sensitivity. High levels of Ps-1, II-2 and IB-1 proteins belonging to basic proline rich proteins (bPRPs) and PRP-1 protein belonging to acid proline rich proteins (aPRPs) were found in OB males, who showed a lower body mass index (BMI) than OB females. High levels of Ps-1 protein and Cystatin SN (Cyst SN) were found in OB non-tasters, who had lower BMI than OB super-tasters. These new insights on the role of salivary proteins as a factor driving the specific weight gain of OB females and super-tasters, suggest the use of specific proteins as a strategic tool modifying taste responses related to eating behavior. |
| first_indexed | 2024-03-10T12:22:40Z |
| format | Article |
| id | doaj.art-e2c9d45c790848af848e5d7d24f761e3 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T12:22:40Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e2c9d45c790848af848e5d7d24f761e32023-11-21T15:23:15ZengMDPI AGMolecules1420-30492021-04-01268224410.3390/molecules26082244Differences in Salivary Proteins as a Function of PROP Taster Status and Gender in Normal Weight and Obese SubjectsMelania Melis0Mariano Mastinu1Stefano Pintus2Tiziana Cabras3Roberto Crnjar4Iole Tomassini Barbarossa5Department of Biomedical Sciences, University of Cagliari, Monserrato, 09042 Cagliari, ItalyDepartment of Biomedical Sciences, University of Cagliari, Monserrato, 09042 Cagliari, ItalyObesity Surgical Unit ARNAS G. Brotzu, 09121 Cagliari, ItalyDepartment of Life and Environmental Sciences, University of Cagliari, Monserrato, 09042 Cagliari, ItalyDepartment of Biomedical Sciences, University of Cagliari, Monserrato, 09042 Cagliari, ItalyDepartment of Biomedical Sciences, University of Cagliari, Monserrato, 09042 Cagliari, ItalyTaste plays an important role in processes such as food choices, nutrition status and health. Salivary proteins contribute to taste sensitivity. Taste reduction has been associated with obesity. Gender influences the obesity predisposition and the genetic ability to perceive the bitterness of 6-<i>n</i>-propylthiouracil (PROP), oral marker for food preferences and consumption. We investigated variations in the profile of salivary proteome, analyzed by HPLC-ESI-MS, between sixty-one normal weight subjects (NW) and fifty-seven subjects with obesity (OB), based on gender and PROP sensitivity. Results showed variations of taste-related salivary proteins between NW and OB, which were differently associated with gender and PROP sensitivity. High levels of Ps-1, II-2 and IB-1 proteins belonging to basic proline rich proteins (bPRPs) and PRP-1 protein belonging to acid proline rich proteins (aPRPs) were found in OB males, who showed a lower body mass index (BMI) than OB females. High levels of Ps-1 protein and Cystatin SN (Cyst SN) were found in OB non-tasters, who had lower BMI than OB super-tasters. These new insights on the role of salivary proteins as a factor driving the specific weight gain of OB females and super-tasters, suggest the use of specific proteins as a strategic tool modifying taste responses related to eating behavior.https://www.mdpi.com/1420-3049/26/8/2244taste sensitivitysalivary proteinsobesitygender |
| spellingShingle | Melania Melis Mariano Mastinu Stefano Pintus Tiziana Cabras Roberto Crnjar Iole Tomassini Barbarossa Differences in Salivary Proteins as a Function of PROP Taster Status and Gender in Normal Weight and Obese Subjects Molecules taste sensitivity salivary proteins obesity gender |
| title | Differences in Salivary Proteins as a Function of PROP Taster Status and Gender in Normal Weight and Obese Subjects |
| title_full | Differences in Salivary Proteins as a Function of PROP Taster Status and Gender in Normal Weight and Obese Subjects |
| title_fullStr | Differences in Salivary Proteins as a Function of PROP Taster Status and Gender in Normal Weight and Obese Subjects |
| title_full_unstemmed | Differences in Salivary Proteins as a Function of PROP Taster Status and Gender in Normal Weight and Obese Subjects |
| title_short | Differences in Salivary Proteins as a Function of PROP Taster Status and Gender in Normal Weight and Obese Subjects |
| title_sort | differences in salivary proteins as a function of prop taster status and gender in normal weight and obese subjects |
| topic | taste sensitivity salivary proteins obesity gender |
| url | https://www.mdpi.com/1420-3049/26/8/2244 |
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