Pharmacophore mapping studies on indolizine derivatives as 15-LOX inhibitors

Pharmacophore mapping studies on indolizine derivatives as 15-LOX inhibitors

This investigation analyzes the common chemical features for 15-lipoxygenase (15-LOX) inhibitors to develop ligand-based pharmacophore models for lipoxygenase inhibitory activity. The present model is based on a dataset of 47 indolizine derivatives that exhibit inhibition against 15-LOX enzyme isola...

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Bibliographic Details
Main Authors: Vikas Sharma, Vipin Kumar
Format: Article
Language:English
Published: Faculty of Pharmacy, Cairo University 2015-06-01
Series:Bulletin of Faculty of Pharmacy Cairo University
Subjects:
Indolizine
Lipoxygenase inhibitors
Modeling
Pharmacophore mapping
3D-QSAR
Online Access:http://www.sciencedirect.com/science/article/pii/S1110093115000083

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