<em>APOB</em> CRISPR-Cas9 Engineering in Hypobetalipoproteinemia: A Promising Tool for Functional Studies of Novel Variants

<em>APOB</em> CRISPR-Cas9 Engineering in Hypobetalipoproteinemia: A Promising Tool for Functional Studies of Novel Variants

Hypobetalipoproteinemia is characterized by LDL-cholesterol and apolipoprotein B (apoB) plasma levels below the fifth percentile for age and sex. Familial hypobetalipoproteinemia (FHBL) is mostly caused by premature termination codons in the <i>APOB</i> gene, a condition associated with...

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Bibliographic Details
Main Authors:	Xavier Vanhoye, Alexandre Janin, Amandine Caillaud, Antoine Rimbert, Fabienne Venet, Morgane Gossez, Wieneke Dijk, Oriane Marmontel, Séverine Nony, Charlotte Chatelain, Christine Durand, Pierre Lindenbaum, Jennifer Rieusset, Bertrand Cariou, Philippe Moulin, Mathilde Di Filippo
Format:	Article
Language:	English
Published:	MDPI AG 2022-04-01
Series:	International Journal of Molecular Sciences
Subjects:	primary hypobetalipoproteinemia apolipoprotein B genome editing variants of uncertain significance functionality secretion
Online Access:	https://www.mdpi.com/1422-0067/23/8/4281

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