Trisomy 18 and necrotizing enterocolitis
Introduction: Both Trisomy 18 (T18) and Necrotizing enterocolitis totalis (NEC-T) are major causes of morbidity and mortality in neonates. However, to our knowledge there has never been a case of a full-term infant born with both T18 and NEC-T published in the literature. Case report: We present a c...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-10-01
|
| Series: | Journal of Pediatric Surgery Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S221357662200238X |
| _version_ | 1811274243061579776 |
|---|---|
| author | Alexandra Maidan Marla A. Sacks Steven L. Raymond Georgi D. Mladenov Faraz A. Khan Andrei Radulescu |
| author_facet | Alexandra Maidan Marla A. Sacks Steven L. Raymond Georgi D. Mladenov Faraz A. Khan Andrei Radulescu |
| author_sort | Alexandra Maidan |
| collection | DOAJ |
| description | Introduction: Both Trisomy 18 (T18) and Necrotizing enterocolitis totalis (NEC-T) are major causes of morbidity and mortality in neonates. However, to our knowledge there has never been a case of a full-term infant born with both T18 and NEC-T published in the literature. Case report: We present a case of NEC totalis in male neonate born at 39 weeks gestation with Trisomy 18. He was diagnosed with T18 in-utero, and after genetic counseling, the mother carried the pregnancy to term. After delivery, the newborn developed signs of respiratory distress, requiring use of continuous positive airway pressure support. On day of life (DOL) 8, multiple bloody bowel movements raised suspicion for NEC and after supplemental investigations prompted a series of exploratory laparotomies that revealed extensive necrotizing enterocolitis involving the entire gastrointestinal tract. On DOL 12, the family opted for palliative care and the patient subsequently expired. Conclusion: To our knowledge, after searching through the English literature, no cases were found showing a neonate with a combination of T18 and NEC-T. |
| first_indexed | 2024-04-12T23:15:31Z |
| format | Article |
| id | doaj.art-e2cdaaae8eab4c27aa5692c8b92ff4fe |
| institution | Directory Open Access Journal |
| issn | 2213-5766 |
| language | English |
| last_indexed | 2024-04-12T23:15:31Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pediatric Surgery Case Reports |
| spelling | doaj.art-e2cdaaae8eab4c27aa5692c8b92ff4fe2022-12-22T03:12:43ZengElsevierJournal of Pediatric Surgery Case Reports2213-57662022-10-0185102411Trisomy 18 and necrotizing enterocolitisAlexandra Maidan0Marla A. Sacks1Steven L. Raymond2Georgi D. Mladenov3Faraz A. Khan4Andrei Radulescu5Loma Linda University School of Medicine, Loma Linda, CA, USADivision of Pediatric Surgery, Loma Linda University Children's Hospital, Loma Linda, CA, USADivision of Pediatric Surgery, Loma Linda University Children's Hospital, Loma Linda, CA, USADivision of Pediatric Surgery, Loma Linda University Children's Hospital, Loma Linda, CA, USALoma Linda University School of Medicine, Loma Linda, CA, USA; Division of Pediatric Surgery, Loma Linda University Children's Hospital, Loma Linda, CA, USALoma Linda University School of Medicine, Loma Linda, CA, USA; Division of Pediatric Surgery, Loma Linda University Children's Hospital, Loma Linda, CA, USA; Corresponding author. Loma Linda University Medical Center, 11175 Campus Street, CP21111, Loma Linda, CA, 92350, USA.Introduction: Both Trisomy 18 (T18) and Necrotizing enterocolitis totalis (NEC-T) are major causes of morbidity and mortality in neonates. However, to our knowledge there has never been a case of a full-term infant born with both T18 and NEC-T published in the literature. Case report: We present a case of NEC totalis in male neonate born at 39 weeks gestation with Trisomy 18. He was diagnosed with T18 in-utero, and after genetic counseling, the mother carried the pregnancy to term. After delivery, the newborn developed signs of respiratory distress, requiring use of continuous positive airway pressure support. On day of life (DOL) 8, multiple bloody bowel movements raised suspicion for NEC and after supplemental investigations prompted a series of exploratory laparotomies that revealed extensive necrotizing enterocolitis involving the entire gastrointestinal tract. On DOL 12, the family opted for palliative care and the patient subsequently expired. Conclusion: To our knowledge, after searching through the English literature, no cases were found showing a neonate with a combination of T18 and NEC-T.http://www.sciencedirect.com/science/article/pii/S221357662200238XNecrotizing enterocolitisNecrotizing enterocolitis totalisTrisomy 18 |
| spellingShingle | Alexandra Maidan Marla A. Sacks Steven L. Raymond Georgi D. Mladenov Faraz A. Khan Andrei Radulescu Trisomy 18 and necrotizing enterocolitis Journal of Pediatric Surgery Case Reports Necrotizing enterocolitis Necrotizing enterocolitis totalis Trisomy 18 |
| title | Trisomy 18 and necrotizing enterocolitis |
| title_full | Trisomy 18 and necrotizing enterocolitis |
| title_fullStr | Trisomy 18 and necrotizing enterocolitis |
| title_full_unstemmed | Trisomy 18 and necrotizing enterocolitis |
| title_short | Trisomy 18 and necrotizing enterocolitis |
| title_sort | trisomy 18 and necrotizing enterocolitis |
| topic | Necrotizing enterocolitis Necrotizing enterocolitis totalis Trisomy 18 |
| url | http://www.sciencedirect.com/science/article/pii/S221357662200238X |
| work_keys_str_mv | AT alexandramaidan trisomy18andnecrotizingenterocolitis AT marlaasacks trisomy18andnecrotizingenterocolitis AT stevenlraymond trisomy18andnecrotizingenterocolitis AT georgidmladenov trisomy18andnecrotizingenterocolitis AT farazakhan trisomy18andnecrotizingenterocolitis AT andreiradulescu trisomy18andnecrotizingenterocolitis |