The prognostic value of deep earlobe creases in patients with acute ischemic stroke
Background and purposeData on earlobe crease (ELC) among patients with acute ischemic stroke (AIS) are limited. Here, we determined the frequency and characteristics of ELC and the prognostic effect of ELC among AIS patients.MethodsA total of 936 patients with acute AIS were enrolled during the peri...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-05-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1096044/full |
| _version_ | 1827936926559109120 |
|---|---|
| author | Jiaping Xu Lixuan Wang Lixuan Wang Chunqing Zhang Jiayun Wang Jiayun Wang Danni Zheng Yaqian Huang Xia Zhang Shoujiang You Yongjun Cao Yongjun Cao Chun-Feng Liu Chun-Feng Liu |
| author_facet | Jiaping Xu Lixuan Wang Lixuan Wang Chunqing Zhang Jiayun Wang Jiayun Wang Danni Zheng Yaqian Huang Xia Zhang Shoujiang You Yongjun Cao Yongjun Cao Chun-Feng Liu Chun-Feng Liu |
| author_sort | Jiaping Xu |
| collection | DOAJ |
| description | Background and purposeData on earlobe crease (ELC) among patients with acute ischemic stroke (AIS) are limited. Here, we determined the frequency and characteristics of ELC and the prognostic effect of ELC among AIS patients.MethodsA total of 936 patients with acute AIS were enrolled during the period between December 2018 and December 2019. The patients were divided into those without and with ELC, unilateral and bilateral ELC, and shallow and deep ELC, according to the photographs taken of the bilateral ears. Logistic regression models were used to estimate the effect of ELC, bilateral ELC, and deep ELC on poor functional outcomes at 90 days (a modified Rankin Scale score ≥2) in AIS patients.ResultsAmong the 936 AIS patients, there were 746 (79.7%) patients with ELC. Among patients with ELC, there were 156 (20.9%) patients with unilateral ELC and 590 (79.1%) with bilateral ELC and 476 (63.8%) patients with shallow ELC and 270 (36.2%) with deep ELC. After adjusting for age, sex, baseline NIHSS score, and other potential covariates, patients with deep ELC were associated with a 1.87-fold [odds ratio (OR) 1.87; 95% confidence interval (CI), 1.13–3.09] and 1.63-fold (OR 1.63; 95%CI, 1.14–2.34) increase in the risk of poor functional outcome at 90 days in comparison with those without ELC or shallow ELC.ConclusionELC was a common phenomenon, and eight out of ten AIS patients had ELC. Most patients had bilateral ELC, and more than one-third had deep ELC. Deep ELC was independently associated with an increased risk of poor functional outcome at 90 days. |
| first_indexed | 2024-03-13T08:18:10Z |
| format | Article |
| id | doaj.art-e2ce46d29a9e4f498257b19c3ae84c33 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-13T08:18:10Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-e2ce46d29a9e4f498257b19c3ae84c332023-05-31T14:34:57ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-05-011010.3389/fcvm.2023.10960441096044The prognostic value of deep earlobe creases in patients with acute ischemic strokeJiaping Xu0Lixuan Wang1Lixuan Wang2Chunqing Zhang3Jiayun Wang4Jiayun Wang5Danni Zheng6Yaqian Huang7Xia Zhang8Shoujiang You9Yongjun Cao10Yongjun Cao11Chun-Feng Liu12Chun-Feng Liu13Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology, Honghui Hospital, Xi’an Jiaotong University, Xi’an, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology, Qinghai University Affiliated Hospital, Xining, ChinaThe George Institute for Global Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, AustraliaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaInstitutes of Neuroscience, Soochow University, Suzhou, ChinaDepartment of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou, ChinaInstitutes of Neuroscience, Soochow University, Suzhou, ChinaBackground and purposeData on earlobe crease (ELC) among patients with acute ischemic stroke (AIS) are limited. Here, we determined the frequency and characteristics of ELC and the prognostic effect of ELC among AIS patients.MethodsA total of 936 patients with acute AIS were enrolled during the period between December 2018 and December 2019. The patients were divided into those without and with ELC, unilateral and bilateral ELC, and shallow and deep ELC, according to the photographs taken of the bilateral ears. Logistic regression models were used to estimate the effect of ELC, bilateral ELC, and deep ELC on poor functional outcomes at 90 days (a modified Rankin Scale score ≥2) in AIS patients.ResultsAmong the 936 AIS patients, there were 746 (79.7%) patients with ELC. Among patients with ELC, there were 156 (20.9%) patients with unilateral ELC and 590 (79.1%) with bilateral ELC and 476 (63.8%) patients with shallow ELC and 270 (36.2%) with deep ELC. After adjusting for age, sex, baseline NIHSS score, and other potential covariates, patients with deep ELC were associated with a 1.87-fold [odds ratio (OR) 1.87; 95% confidence interval (CI), 1.13–3.09] and 1.63-fold (OR 1.63; 95%CI, 1.14–2.34) increase in the risk of poor functional outcome at 90 days in comparison with those without ELC or shallow ELC.ConclusionELC was a common phenomenon, and eight out of ten AIS patients had ELC. Most patients had bilateral ELC, and more than one-third had deep ELC. Deep ELC was independently associated with an increased risk of poor functional outcome at 90 days.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1096044/fullacute ischemic strokeearlobe creaseprognostic valuefrequencycharacteristics |
| spellingShingle | Jiaping Xu Lixuan Wang Lixuan Wang Chunqing Zhang Jiayun Wang Jiayun Wang Danni Zheng Yaqian Huang Xia Zhang Shoujiang You Yongjun Cao Yongjun Cao Chun-Feng Liu Chun-Feng Liu The prognostic value of deep earlobe creases in patients with acute ischemic stroke Frontiers in Cardiovascular Medicine acute ischemic stroke earlobe crease prognostic value frequency characteristics |
| title | The prognostic value of deep earlobe creases in patients with acute ischemic stroke |
| title_full | The prognostic value of deep earlobe creases in patients with acute ischemic stroke |
| title_fullStr | The prognostic value of deep earlobe creases in patients with acute ischemic stroke |
| title_full_unstemmed | The prognostic value of deep earlobe creases in patients with acute ischemic stroke |
| title_short | The prognostic value of deep earlobe creases in patients with acute ischemic stroke |
| title_sort | prognostic value of deep earlobe creases in patients with acute ischemic stroke |
| topic | acute ischemic stroke earlobe crease prognostic value frequency characteristics |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1096044/full |
| work_keys_str_mv | AT jiapingxu theprognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT lixuanwang theprognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT lixuanwang theprognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT chunqingzhang theprognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT jiayunwang theprognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT jiayunwang theprognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT dannizheng theprognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT yaqianhuang theprognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT xiazhang theprognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT shoujiangyou theprognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT yongjuncao theprognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT yongjuncao theprognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT chunfengliu theprognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT chunfengliu theprognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT jiapingxu prognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT lixuanwang prognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT lixuanwang prognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT chunqingzhang prognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT jiayunwang prognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT jiayunwang prognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT dannizheng prognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT yaqianhuang prognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT xiazhang prognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT shoujiangyou prognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT yongjuncao prognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT yongjuncao prognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT chunfengliu prognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke AT chunfengliu prognosticvalueofdeepearlobecreasesinpatientswithacuteischemicstroke |