Clinico-Morphological Features and Immunohistochemical Profile of a Rare Case of Three Synchronous Primary Malignancies in the Female Genital Tract
(1) Background: Synchronous tumors are defined as tumors that occur at the same time, appearing within 2 months, according to the Surveillance Epidemiology and End Results Program, with a frequency of tertiary tumors of 0.5%. The purpose of this presentation is to report a case of three synchronous...
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MDPI AG
2024-02-01
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| Online Access: | https://www.mdpi.com/2571-841X/7/1/14 |
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| author | Mădălina Boșoteanu Raluca Ioana Vodă Gabriela Izabela Balţǎtescu Mariana Aşchie Luana-Andreea Nurla Cristian Ionuţ Orǎşanu |
| author_facet | Mădălina Boșoteanu Raluca Ioana Vodă Gabriela Izabela Balţǎtescu Mariana Aşchie Luana-Andreea Nurla Cristian Ionuţ Orǎşanu |
| author_sort | Mădălina Boșoteanu |
| collection | DOAJ |
| description | (1) Background: Synchronous tumors are defined as tumors that occur at the same time, appearing within 2 months, according to the Surveillance Epidemiology and End Results Program, with a frequency of tertiary tumors of 0.5%. The purpose of this presentation is to report a case of three synchronous tumors of the female genital tract, given the fact that it represents a challenge both therapeutically and in demonstrating that the malignant lesions are completely different from each other. (2) Methods: We report the case of a 45 year-old patient diagnosed with three synchronous tumors developed in the genital tract: clear-cell ovarian carcinoma, uterine endometrioid adenocarcinoma, and cervical adenosquamous carcinoma. (3) Results: Total hysterectomy with bilateral anexectomy was performed and accompanied by a biopsy of the greater omentum. The evolution of the patient was favorable during chemotherapy, but she died two weeks after the completion of this treatment, from a cause secondary to the adverse effects determined by it, namely, severe thrombopenia which caused a massive lower digestive hemorrhage. (4) Conclusions: This case demonstrates the maximum importance of the involvement of adjuvant diagnostic techniques, especially when it comes to a diagnostic challenge with direct implications in the subsequent therapy of the patient. |
| first_indexed | 2024-04-24T17:52:14Z |
| format | Article |
| id | doaj.art-e2ce8ae566d84ed6a44cfc63bf0739f4 |
| institution | Directory Open Access Journal |
| issn | 2571-841X |
| language | English |
| last_indexed | 2024-04-24T17:52:14Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Reports |
| spelling | doaj.art-e2ce8ae566d84ed6a44cfc63bf0739f42024-03-27T14:02:57ZengMDPI AGReports2571-841X2024-02-01711410.3390/reports7010014Clinico-Morphological Features and Immunohistochemical Profile of a Rare Case of Three Synchronous Primary Malignancies in the Female Genital TractMădălina Boșoteanu0Raluca Ioana Vodă1Gabriela Izabela Balţǎtescu2Mariana Aşchie3Luana-Andreea Nurla4Cristian Ionuţ Orǎşanu5Clinical Service of Pathology, “Sf. Apostol Andrei” Emergency County Hospital, 900591 Constanţa, RomaniaClinical Service of Pathology, “Sf. Apostol Andrei” Emergency County Hospital, 900591 Constanţa, RomaniaClinical Service of Pathology, “Sf. Apostol Andrei” Emergency County Hospital, 900591 Constanţa, RomaniaClinical Service of Pathology, “Sf. Apostol Andrei” Emergency County Hospital, 900591 Constanţa, Romania“Elias” Emergency University Hospital, Dermatovenerology Department, 011461 Bucharest, RomaniaClinical Service of Pathology, “Sf. Apostol Andrei” Emergency County Hospital, 900591 Constanţa, Romania(1) Background: Synchronous tumors are defined as tumors that occur at the same time, appearing within 2 months, according to the Surveillance Epidemiology and End Results Program, with a frequency of tertiary tumors of 0.5%. The purpose of this presentation is to report a case of three synchronous tumors of the female genital tract, given the fact that it represents a challenge both therapeutically and in demonstrating that the malignant lesions are completely different from each other. (2) Methods: We report the case of a 45 year-old patient diagnosed with three synchronous tumors developed in the genital tract: clear-cell ovarian carcinoma, uterine endometrioid adenocarcinoma, and cervical adenosquamous carcinoma. (3) Results: Total hysterectomy with bilateral anexectomy was performed and accompanied by a biopsy of the greater omentum. The evolution of the patient was favorable during chemotherapy, but she died two weeks after the completion of this treatment, from a cause secondary to the adverse effects determined by it, namely, severe thrombopenia which caused a massive lower digestive hemorrhage. (4) Conclusions: This case demonstrates the maximum importance of the involvement of adjuvant diagnostic techniques, especially when it comes to a diagnostic challenge with direct implications in the subsequent therapy of the patient.https://www.mdpi.com/2571-841X/7/1/14cervixovaryp53prognosisuterus |
| spellingShingle | Mădălina Boșoteanu Raluca Ioana Vodă Gabriela Izabela Balţǎtescu Mariana Aşchie Luana-Andreea Nurla Cristian Ionuţ Orǎşanu Clinico-Morphological Features and Immunohistochemical Profile of a Rare Case of Three Synchronous Primary Malignancies in the Female Genital Tract Reports cervix ovary p53 prognosis uterus |
| title | Clinico-Morphological Features and Immunohistochemical Profile of a Rare Case of Three Synchronous Primary Malignancies in the Female Genital Tract |
| title_full | Clinico-Morphological Features and Immunohistochemical Profile of a Rare Case of Three Synchronous Primary Malignancies in the Female Genital Tract |
| title_fullStr | Clinico-Morphological Features and Immunohistochemical Profile of a Rare Case of Three Synchronous Primary Malignancies in the Female Genital Tract |
| title_full_unstemmed | Clinico-Morphological Features and Immunohistochemical Profile of a Rare Case of Three Synchronous Primary Malignancies in the Female Genital Tract |
| title_short | Clinico-Morphological Features and Immunohistochemical Profile of a Rare Case of Three Synchronous Primary Malignancies in the Female Genital Tract |
| title_sort | clinico morphological features and immunohistochemical profile of a rare case of three synchronous primary malignancies in the female genital tract |
| topic | cervix ovary p53 prognosis uterus |
| url | https://www.mdpi.com/2571-841X/7/1/14 |
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