Evaluation of pure-tone audiometric protocols in vestibular schwannoma screening
The objective was to evaluate the pure-tone audiogram-based screening protocols in VS diagnostics. We retrospectively analyzed presenting symptoms, pure tone audiometry and MRI finding from 246 VS patients and 442 controls were collected to test screening protocols (AAO-HNS, AMCLASS-A/B, Charing Cro...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-07-01
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| Series: | Journal of Otology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1672293020301185 |
| _version_ | 1819000774108119040 |
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| author | Matej Vnencak Elina Huttunen Antti A. Aarnisalo Jussi Jero Katja Liukkonen Saku T. Sinkkonen |
| author_facet | Matej Vnencak Elina Huttunen Antti A. Aarnisalo Jussi Jero Katja Liukkonen Saku T. Sinkkonen |
| author_sort | Matej Vnencak |
| collection | DOAJ |
| description | The objective was to evaluate the pure-tone audiogram-based screening protocols in VS diagnostics. We retrospectively analyzed presenting symptoms, pure tone audiometry and MRI finding from 246 VS patients and 442 controls were collected to test screening protocols (AAO-HNS, AMCLASS-A/B, Charing Cross, Cueva, DOH, Nashville, Oxford, Rule3000, Schlauch, Seattle, Sunderland) for sensitivity and specificity. Results were pooled with data from five other studies, and analysis of sensitivity, specificity and positive likelihood ratio (LR+) for each protocol was performed. Our results show that protocols with significantly higher sensitivity (AMCLASS-A/B, Nashville) show also significantly lowest specificity, and tend to have low association (positive likelihood ratio, LR+) to the VS. The highest LR+ was found for protocols AAO-HNS, Rule3000 and Seattle. In conclusions, knowing their properties, screening protocols are simple decision-making tools in VS diagnostic. To use the advantage of the highest sensitivity, protocols AMCLASS-A + B or Nashville can be of choice. For more reasonable approach, applying the protocols with high LR+ (AAO-HNS, Rule3000, Seattle) may reduce the overall number of MRI scans at expense of only few primarily undiagnosed VS. |
| first_indexed | 2024-12-20T22:38:39Z |
| format | Article |
| id | doaj.art-e2cf5b98c8d443d7ad983fb6d98a875c |
| institution | Directory Open Access Journal |
| issn | 1672-2930 |
| language | English |
| last_indexed | 2024-12-20T22:38:39Z |
| publishDate | 2021-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Otology |
| spelling | doaj.art-e2cf5b98c8d443d7ad983fb6d98a875c2022-12-21T19:24:31ZengElsevierJournal of Otology1672-29302021-07-01163138143Evaluation of pure-tone audiometric protocols in vestibular schwannoma screeningMatej Vnencak0Elina Huttunen1Antti A. Aarnisalo2Jussi Jero3Katja Liukkonen4Saku T. Sinkkonen5Department of Otorhinolaryngology - Head and Neck Surgery, Turku University Hospital, Turku, Finland; Head and Neck Center, Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital, And University of Helsinki, Helsinki, FinlandHead and Neck Center, Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital, And University of Helsinki, Helsinki, FinlandHead and Neck Center, Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital, And University of Helsinki, Helsinki, FinlandHead and Neck Center, Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital, And University of Helsinki, Helsinki, FinlandHead and Neck Center, Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital, And University of Helsinki, Helsinki, FinlandHead and Neck Center, Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital, And University of Helsinki, Helsinki, Finland; Corresponding author. Head and Neck Center, Otorhinolaryngology – Head and Neck Surgery, Helsinki University Hospital, POB 263, 00029 HUS, Helsinki, Finland.The objective was to evaluate the pure-tone audiogram-based screening protocols in VS diagnostics. We retrospectively analyzed presenting symptoms, pure tone audiometry and MRI finding from 246 VS patients and 442 controls were collected to test screening protocols (AAO-HNS, AMCLASS-A/B, Charing Cross, Cueva, DOH, Nashville, Oxford, Rule3000, Schlauch, Seattle, Sunderland) for sensitivity and specificity. Results were pooled with data from five other studies, and analysis of sensitivity, specificity and positive likelihood ratio (LR+) for each protocol was performed. Our results show that protocols with significantly higher sensitivity (AMCLASS-A/B, Nashville) show also significantly lowest specificity, and tend to have low association (positive likelihood ratio, LR+) to the VS. The highest LR+ was found for protocols AAO-HNS, Rule3000 and Seattle. In conclusions, knowing their properties, screening protocols are simple decision-making tools in VS diagnostic. To use the advantage of the highest sensitivity, protocols AMCLASS-A + B or Nashville can be of choice. For more reasonable approach, applying the protocols with high LR+ (AAO-HNS, Rule3000, Seattle) may reduce the overall number of MRI scans at expense of only few primarily undiagnosed VS.http://www.sciencedirect.com/science/article/pii/S1672293020301185Vestibular schwannomaAsymmetric sensorineural hearing lossScreening protocol |
| spellingShingle | Matej Vnencak Elina Huttunen Antti A. Aarnisalo Jussi Jero Katja Liukkonen Saku T. Sinkkonen Evaluation of pure-tone audiometric protocols in vestibular schwannoma screening Journal of Otology Vestibular schwannoma Asymmetric sensorineural hearing loss Screening protocol |
| title | Evaluation of pure-tone audiometric protocols in vestibular schwannoma screening |
| title_full | Evaluation of pure-tone audiometric protocols in vestibular schwannoma screening |
| title_fullStr | Evaluation of pure-tone audiometric protocols in vestibular schwannoma screening |
| title_full_unstemmed | Evaluation of pure-tone audiometric protocols in vestibular schwannoma screening |
| title_short | Evaluation of pure-tone audiometric protocols in vestibular schwannoma screening |
| title_sort | evaluation of pure tone audiometric protocols in vestibular schwannoma screening |
| topic | Vestibular schwannoma Asymmetric sensorineural hearing loss Screening protocol |
| url | http://www.sciencedirect.com/science/article/pii/S1672293020301185 |
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