Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals
Human immunodeficiency virus (HIV) infection has continued to be the subject of study since its discovery nearly 40 years ago. Significant advances in research and intake of antiretroviral therapy (ART) have slowed the progression and appearance of the disease symptoms and the incidence of concomita...
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MDPI AG
2022-05-01
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author | Angélica Saraí Jiménez-Osorio Sinaí Jaen-Vega Eduardo Fernández-Martínez María Araceli Ortíz-Rodríguez María Fernanda Martínez-Salazar Reyna Cristina Jiménez-Sánchez Olga Rocío Flores-Chávez Esther Ramírez-Moreno José Arias-Rico Felipe Arteaga-García Diego Estrada-Luna |
author_facet | Angélica Saraí Jiménez-Osorio Sinaí Jaen-Vega Eduardo Fernández-Martínez María Araceli Ortíz-Rodríguez María Fernanda Martínez-Salazar Reyna Cristina Jiménez-Sánchez Olga Rocío Flores-Chávez Esther Ramírez-Moreno José Arias-Rico Felipe Arteaga-García Diego Estrada-Luna |
author_sort | Angélica Saraí Jiménez-Osorio |
collection | DOAJ |
description | Human immunodeficiency virus (HIV) infection has continued to be the subject of study since its discovery nearly 40 years ago. Significant advances in research and intake of antiretroviral therapy (ART) have slowed the progression and appearance of the disease symptoms and the incidence of concomitant diseases, which are the leading cause of death in HIV+ persons. However, the prolongation of ART is closely related to chronic degenerative diseases and pathologies caused by oxidative stress (OS) and alterations in lipid metabolism (increased cholesterol levels), both of which are conditions of ART. Therefore, recent research focuses on using natural therapies to diminish the effects of ART and HIV infection: regulating lipid metabolism and reducing OS status. The present review summarizes current information on OS and cholesterol metabolism in HIV+ persons and how the consumption of certain phytochemicals can modulate these. For this purpose, MEDLINE and SCOPUS databases were consulted to identify publications investigating HIV disease and natural therapies and their associated effects. |
first_indexed | 2024-03-10T03:43:57Z |
format | Article |
id | doaj.art-e2d20a0fa0eb4f67b272f061e232bb7c |
institution | Directory Open Access Journal |
issn | 1661-6596 1422-0067 |
language | English |
last_indexed | 2024-03-10T03:43:57Z |
publishDate | 2022-05-01 |
publisher | MDPI AG |
record_format | Article |
series | International Journal of Molecular Sciences |
spelling | doaj.art-e2d20a0fa0eb4f67b272f061e232bb7c2023-11-23T11:25:19ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-012310559210.3390/ijms23105592Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant PhytochemicalsAngélica Saraí Jiménez-Osorio0Sinaí Jaen-Vega1Eduardo Fernández-Martínez2María Araceli Ortíz-Rodríguez3María Fernanda Martínez-Salazar4Reyna Cristina Jiménez-Sánchez5Olga Rocío Flores-Chávez6Esther Ramírez-Moreno7José Arias-Rico8Felipe Arteaga-García9Diego Estrada-Luna10Área Académica de Enfermería, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado Hidalgo, Circuito Ex Hacienda La Concepción S/N, Carretera Pachuca-Actopan, San Agustín Tlaxiaca 42160, MexicoÁrea Académica de Enfermería, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado Hidalgo, Circuito Ex Hacienda La Concepción S/N, Carretera Pachuca-Actopan, San Agustín Tlaxiaca 42160, MexicoLaboratorio de Química Medicinal y Farmacología, Centro de Investigación en Biología de la Reproducción, Área Académica de Medicina, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Calle Dr. Eliseo Ramírez Ulloa no. 400, Col. Doctores, Pachuca Hidalgo 42090, MexicoFacultad de Nutrición, Universidad Autónoma del Estado de Morelos, Iztaccíhuatl 100 Col. Los Volcanes, Cuernavaca 62350, MexicoFacultad de Ciencias del Deporte, Facultad de Farmacia Universidad Autónoma del Estado de Morelos, Av. Universidad No. 1001 Col. Chamilpa, Cuernavaca 62209, MexicoÁrea Académica de Enfermería, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado Hidalgo, Circuito Ex Hacienda La Concepción S/N, Carretera Pachuca-Actopan, San Agustín Tlaxiaca 42160, MexicoÁrea Académica de Enfermería, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado Hidalgo, Circuito Ex Hacienda La Concepción S/N, Carretera Pachuca-Actopan, San Agustín Tlaxiaca 42160, MexicoÁrea Académica de Nutrición, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado Hidalgo, Circuito Ex Hacienda La Concepción S/N, Carretera Pachuca-Actopan, San Agustín Tlaxiaca 42160, MexicoÁrea Académica de Enfermería, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado Hidalgo, Circuito Ex Hacienda La Concepción S/N, Carretera Pachuca-Actopan, San Agustín Tlaxiaca 42160, MexicoCoordinación de Enseñanza e Investigación, Hospital del Niño DIF Hidalgo, Carretera México-Pachuca km 82, Pachuca de Soto 42080, MexicoÁrea Académica de Enfermería, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado Hidalgo, Circuito Ex Hacienda La Concepción S/N, Carretera Pachuca-Actopan, San Agustín Tlaxiaca 42160, MexicoHuman immunodeficiency virus (HIV) infection has continued to be the subject of study since its discovery nearly 40 years ago. Significant advances in research and intake of antiretroviral therapy (ART) have slowed the progression and appearance of the disease symptoms and the incidence of concomitant diseases, which are the leading cause of death in HIV+ persons. However, the prolongation of ART is closely related to chronic degenerative diseases and pathologies caused by oxidative stress (OS) and alterations in lipid metabolism (increased cholesterol levels), both of which are conditions of ART. Therefore, recent research focuses on using natural therapies to diminish the effects of ART and HIV infection: regulating lipid metabolism and reducing OS status. The present review summarizes current information on OS and cholesterol metabolism in HIV+ persons and how the consumption of certain phytochemicals can modulate these. For this purpose, MEDLINE and SCOPUS databases were consulted to identify publications investigating HIV disease and natural therapies and their associated effects.https://www.mdpi.com/1422-0067/23/10/5592antiretroviral therapyphytochemicalslipid metabolismgenesHIVoxidative stress |
spellingShingle | Angélica Saraí Jiménez-Osorio Sinaí Jaen-Vega Eduardo Fernández-Martínez María Araceli Ortíz-Rodríguez María Fernanda Martínez-Salazar Reyna Cristina Jiménez-Sánchez Olga Rocío Flores-Chávez Esther Ramírez-Moreno José Arias-Rico Felipe Arteaga-García Diego Estrada-Luna Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals International Journal of Molecular Sciences antiretroviral therapy phytochemicals lipid metabolism genes HIV oxidative stress |
title | Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals |
title_full | Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals |
title_fullStr | Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals |
title_full_unstemmed | Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals |
title_short | Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals |
title_sort | antiretroviral therapy induced dysregulation of gene expression and lipid metabolism in hiv patients beneficial role of antioxidant phytochemicals |
topic | antiretroviral therapy phytochemicals lipid metabolism genes HIV oxidative stress |
url | https://www.mdpi.com/1422-0067/23/10/5592 |
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