Osteoarthritis, Corticosteroids and Role of CYP Genes in COVID-19 Patients: A Mini Review
Objectives of this review is to evaluate the role of cytochrome P450 gene polymorphisms in COVID-19 infected patients with pre-existing OA on corticosteroids. The purpose of this review is to analyze whether polymorphisms of Cytochrome p450 isoforms (CYP2C9 and CYP3A4) affect the dosage of steroids...
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| Format: | Article |
| Language: | English |
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Journal of Pure and Applied Microbiology
2022-03-01
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| Series: | Journal of Pure and Applied Microbiology |
| Subjects: | |
| Online Access: | https://microbiologyjournal.org/osteoarthritis-corticosteroids-and-role-of-cyp-genes-in-covid-19-patients-a-mini-review/ |
| _version_ | 1818287161328271360 |
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| author | Usha Adiga Sachidananda Adiga Varashree Bolar Suryakanth Desy Thayyil Menambath |
| author_facet | Usha Adiga Sachidananda Adiga Varashree Bolar Suryakanth Desy Thayyil Menambath |
| author_sort | Usha Adiga |
| collection | DOAJ |
| description | Objectives of this review is to evaluate the role of cytochrome P450 gene polymorphisms in COVID-19 infected patients with pre-existing OA on corticosteroids. The purpose of this review is to analyze whether polymorphisms of Cytochrome p450 isoforms (CYP2C9 and CYP3A4) affect the dosage of steroids in OA patients in COVID-19 infected patients. This review may provide more therapeutic options; suggest a few guidelines which may be useful in managing COVID-19 patients with pre-existing osteoarthritis. The important role of corticosteroids in treating patients infected with COVID-19 with preexisting osteoarthritis, its influence on incidence of mortality or morbidity may be highlighted. The influence of CYP enzymes and their polymorphisms suggest safety of treatments as well as the possible need for the dosage adjustment or their discontinuation. |
| first_indexed | 2024-12-13T01:36:05Z |
| format | Article |
| id | doaj.art-e2d26c3a52c74f23ae11ac70972cc673 |
| institution | Directory Open Access Journal |
| issn | 0973-7510 2581-690X |
| language | English |
| last_indexed | 2024-12-13T01:36:05Z |
| publishDate | 2022-03-01 |
| publisher | Journal of Pure and Applied Microbiology |
| record_format | Article |
| series | Journal of Pure and Applied Microbiology |
| spelling | doaj.art-e2d26c3a52c74f23ae11ac70972cc6732022-12-22T00:03:54ZengJournal of Pure and Applied MicrobiologyJournal of Pure and Applied Microbiology0973-75102581-690X2022-03-011611825https://doi.org/10.22207/JPAM.16.1.28Osteoarthritis, Corticosteroids and Role of CYP Genes in COVID-19 Patients: A Mini ReviewUsha Adigahttps://orcid.org/0000-0001-7832-3991Sachidananda Adigahttps://orcid.org/0000-0002-6996-8592Varashree Bolar Suryakanthhttps://orcid.org/0000-0002-1924-3550Desy Thayyil MenambathObjectives of this review is to evaluate the role of cytochrome P450 gene polymorphisms in COVID-19 infected patients with pre-existing OA on corticosteroids. The purpose of this review is to analyze whether polymorphisms of Cytochrome p450 isoforms (CYP2C9 and CYP3A4) affect the dosage of steroids in OA patients in COVID-19 infected patients. This review may provide more therapeutic options; suggest a few guidelines which may be useful in managing COVID-19 patients with pre-existing osteoarthritis. The important role of corticosteroids in treating patients infected with COVID-19 with preexisting osteoarthritis, its influence on incidence of mortality or morbidity may be highlighted. The influence of CYP enzymes and their polymorphisms suggest safety of treatments as well as the possible need for the dosage adjustment or their discontinuation.https://microbiologyjournal.org/osteoarthritis-corticosteroids-and-role-of-cyp-genes-in-covid-19-patients-a-mini-review/covid-19osteoarthritiscorticosteroidscytochrome p450polymorphism |
| spellingShingle | Usha Adiga Sachidananda Adiga Varashree Bolar Suryakanth Desy Thayyil Menambath Osteoarthritis, Corticosteroids and Role of CYP Genes in COVID-19 Patients: A Mini Review Journal of Pure and Applied Microbiology covid-19 osteoarthritis corticosteroids cytochrome p450 polymorphism |
| title | Osteoarthritis, Corticosteroids and Role of CYP Genes in COVID-19 Patients: A Mini Review |
| title_full | Osteoarthritis, Corticosteroids and Role of CYP Genes in COVID-19 Patients: A Mini Review |
| title_fullStr | Osteoarthritis, Corticosteroids and Role of CYP Genes in COVID-19 Patients: A Mini Review |
| title_full_unstemmed | Osteoarthritis, Corticosteroids and Role of CYP Genes in COVID-19 Patients: A Mini Review |
| title_short | Osteoarthritis, Corticosteroids and Role of CYP Genes in COVID-19 Patients: A Mini Review |
| title_sort | osteoarthritis corticosteroids and role of cyp genes in covid 19 patients a mini review |
| topic | covid-19 osteoarthritis corticosteroids cytochrome p450 polymorphism |
| url | https://microbiologyjournal.org/osteoarthritis-corticosteroids-and-role-of-cyp-genes-in-covid-19-patients-a-mini-review/ |
| work_keys_str_mv | AT ushaadiga osteoarthritiscorticosteroidsandroleofcypgenesincovid19patientsaminireview AT sachidanandaadiga osteoarthritiscorticosteroidsandroleofcypgenesincovid19patientsaminireview AT varashreebolarsuryakanth osteoarthritiscorticosteroidsandroleofcypgenesincovid19patientsaminireview AT desythayyilmenambath osteoarthritiscorticosteroidsandroleofcypgenesincovid19patientsaminireview |