Recurrence after percutaneous radiofrequency ablation of hepatocellular carcinoma: Analysis of the pattern and risk factors
BackgroundHepatocellular carcinoma (HCC) frequently relapses after minimally invasive treatment. This study aimed to observe the influencing factors of different recurrence patterns after radiofrequency ablation (RFA) for the treatment of recurrence.MethodsThe medical records of HCC patients who und...
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| Format: | Article |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1018715/full |
| _version_ | 1797895727239659520 |
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| author | Rui Chen Beining Hou Yanzhao Zhou Tuo Zhang Tuo Zhang Zhengzheng Wang Xun Chen Yingwei Zhang Man Chen Man Chen |
| author_facet | Rui Chen Beining Hou Yanzhao Zhou Tuo Zhang Tuo Zhang Zhengzheng Wang Xun Chen Yingwei Zhang Man Chen Man Chen |
| author_sort | Rui Chen |
| collection | DOAJ |
| description | BackgroundHepatocellular carcinoma (HCC) frequently relapses after minimally invasive treatment. This study aimed to observe the influencing factors of different recurrence patterns after radiofrequency ablation (RFA) for the treatment of recurrence.MethodsThe medical records of HCC patients who underwent RFA between January 2010 and January 2019 were retrospectively reviewed. HCC recurrence is classified into three types: local tumour progression (LTP), intrahepatic distant metastasis, and extrahepatic metastasis. Risk factors, overall survival (OS), and disease-free survival (DFS) were assessed for each modality. Among the risk factors are age, gender, liver function tests, blood tests, and tumour size. The OS and DFS curves were measured by the Kaplan-Meier method.Results406 patients who had undergone RFA were included in the study. The median survival for OS and DFS were 120 and 43.6 months. During follow-up, 39, 312, and 55 patients developed LTP, intrahepatic distant metastasis, and extrahepatic metastatic recurrence, respectively. The independent risk factors for each type were as follows: WBC > 5.55*109/L was an independent risk factor for local recurrence. Multiple tumours, extrahepatic metastases, and AFP > 200 ng/ml were used for intrahepatic metastases. Age (P = 0.030), recurrence pattern (P < 0.001) and Child-Pugh class B (P = 0.015) were independent predictors of OS.ConclusionsAccording to our classification, each pattern of recurrence has different risk factors for recurrence, OS, and DFS. |
| first_indexed | 2024-04-10T07:30:22Z |
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| id | doaj.art-e2d2e784ed2c46269f61f77d1a45abb5 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-10T07:30:22Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-e2d2e784ed2c46269f61f77d1a45abb52023-02-23T17:38:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2023-02-011310.3389/fonc.2023.10187151018715Recurrence after percutaneous radiofrequency ablation of hepatocellular carcinoma: Analysis of the pattern and risk factorsRui Chen0Beining Hou1Yanzhao Zhou2Tuo Zhang3Tuo Zhang4Zhengzheng Wang5Xun Chen6Yingwei Zhang7Man Chen8Man Chen9Department of Critical Care Medicine, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, ChinaFaculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, ChinaDepartment of Critical Care Medicine, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Critical Care Medicine, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, ChinaDepartment of Hepatobiliary and Pancreatic Surgery, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, ChinaBeijing Key Laboratory of Mobile Computing and Pervasive Device, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, ChinaDepartment of Critical Care Medicine, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, ChinaDepartment of Critical Care Medicine, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, ChinaBackgroundHepatocellular carcinoma (HCC) frequently relapses after minimally invasive treatment. This study aimed to observe the influencing factors of different recurrence patterns after radiofrequency ablation (RFA) for the treatment of recurrence.MethodsThe medical records of HCC patients who underwent RFA between January 2010 and January 2019 were retrospectively reviewed. HCC recurrence is classified into three types: local tumour progression (LTP), intrahepatic distant metastasis, and extrahepatic metastasis. Risk factors, overall survival (OS), and disease-free survival (DFS) were assessed for each modality. Among the risk factors are age, gender, liver function tests, blood tests, and tumour size. The OS and DFS curves were measured by the Kaplan-Meier method.Results406 patients who had undergone RFA were included in the study. The median survival for OS and DFS were 120 and 43.6 months. During follow-up, 39, 312, and 55 patients developed LTP, intrahepatic distant metastasis, and extrahepatic metastatic recurrence, respectively. The independent risk factors for each type were as follows: WBC > 5.55*109/L was an independent risk factor for local recurrence. Multiple tumours, extrahepatic metastases, and AFP > 200 ng/ml were used for intrahepatic metastases. Age (P = 0.030), recurrence pattern (P < 0.001) and Child-Pugh class B (P = 0.015) were independent predictors of OS.ConclusionsAccording to our classification, each pattern of recurrence has different risk factors for recurrence, OS, and DFS.https://www.frontiersin.org/articles/10.3389/fonc.2023.1018715/fullhepatocellular carcinoma (HCC)radiofrequency ablation (RFA)overall survival (OS)disease-free survival (DFS)prognosisrecurrence |
| spellingShingle | Rui Chen Beining Hou Yanzhao Zhou Tuo Zhang Tuo Zhang Zhengzheng Wang Xun Chen Yingwei Zhang Man Chen Man Chen Recurrence after percutaneous radiofrequency ablation of hepatocellular carcinoma: Analysis of the pattern and risk factors Frontiers in Oncology hepatocellular carcinoma (HCC) radiofrequency ablation (RFA) overall survival (OS) disease-free survival (DFS) prognosis recurrence |
| title | Recurrence after percutaneous radiofrequency ablation of hepatocellular carcinoma: Analysis of the pattern and risk factors |
| title_full | Recurrence after percutaneous radiofrequency ablation of hepatocellular carcinoma: Analysis of the pattern and risk factors |
| title_fullStr | Recurrence after percutaneous radiofrequency ablation of hepatocellular carcinoma: Analysis of the pattern and risk factors |
| title_full_unstemmed | Recurrence after percutaneous radiofrequency ablation of hepatocellular carcinoma: Analysis of the pattern and risk factors |
| title_short | Recurrence after percutaneous radiofrequency ablation of hepatocellular carcinoma: Analysis of the pattern and risk factors |
| title_sort | recurrence after percutaneous radiofrequency ablation of hepatocellular carcinoma analysis of the pattern and risk factors |
| topic | hepatocellular carcinoma (HCC) radiofrequency ablation (RFA) overall survival (OS) disease-free survival (DFS) prognosis recurrence |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1018715/full |
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