A case of neonatal tsutsugamushi disease diagnosed with the aid of rickettsial macrogenomic detection
Abstract Background Tsutsugamushi, also known as bush typhus, is a naturally occurring disease caused by Orientia tsutsugamushi. We reported a case of vertical mother-to-newborn transmission of Orientia tsutsugamushi infection in a newborn from Yunnan (China). Case presentation Decreased fetal movem...
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | BMC Pediatrics |
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| Online Access: | https://doi.org/10.1186/s12887-024-04561-0 |
| _version_ | 1797273206025879552 |
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| author | Xu Yang Ling Zhang Shanping Chen Wei Chen Yushan Zhang Yi Zhang Jialong Liang Ying Lv Weiyan Wang Yini Zhou Rui Huang Dongju Pan Xueyu Li Qiurong Li |
| author_facet | Xu Yang Ling Zhang Shanping Chen Wei Chen Yushan Zhang Yi Zhang Jialong Liang Ying Lv Weiyan Wang Yini Zhou Rui Huang Dongju Pan Xueyu Li Qiurong Li |
| author_sort | Xu Yang |
| collection | DOAJ |
| description | Abstract Background Tsutsugamushi, also known as bush typhus, is a naturally occurring disease caused by Orientia tsutsugamushi. We reported a case of vertical mother-to-newborn transmission of Orientia tsutsugamushi infection in a newborn from Yunnan (China). Case presentation Decreased fetal movements were observed at 39 weeks of gestation. After birth, the newborn (female) had recurrent fever, shortness of breath, and bruising around the mouth and extremities. At 5 h 58 min of age, the newborn was admitted for fever, shortness of breath and generalized rash. The liver was palpable 3 cm below the costal margin, and the limbs showed pitting edema. There was subcutaneous bleeding. Investigations suggested heavy infection, myocardial damage, decreased platelets. Treatment with cefotaxime and ampicillin failed. The mother was hospitalized at 29 weeks of gestation with a fever for 4 consecutive days, and an ulcerated crust was found in the popliteal fossa. Due to this pregnancy history, A diagnosis of Orientia tsutsugamushi infection was suspected in our index case and confirmed by macrogenomic testing and she was treated with vancomycin and meropenem, and later azithromycin for 1 week. The newborn was discharged in good general condition, gradually normalizing body temperature, and decreasing rash and jaundice. There were no abnormalities on subsequent blood macrogenomic tests for the baby. And one month later she showed good mental health, sleep, and food intake and no fever, rash, or jaundice. Conclusion Determining the cause of symptoms is the key to treating diseases, especially the rare diseases that can be misdiagnosed. Suitable for people with Infectious Diseases; Neonatology; Obstetrics. |
| first_indexed | 2024-03-07T14:41:15Z |
| format | Article |
| id | doaj.art-e2d3bf27badc409aa4d4259bfa55f80c |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-03-07T14:41:15Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-e2d3bf27badc409aa4d4259bfa55f80c2024-03-05T20:23:12ZengBMCBMC Pediatrics1471-24312024-02-012411510.1186/s12887-024-04561-0A case of neonatal tsutsugamushi disease diagnosed with the aid of rickettsial macrogenomic detectionXu Yang0Ling Zhang1Shanping Chen2Wei Chen3Yushan Zhang4Yi Zhang5Jialong Liang6Ying Lv7Weiyan Wang8Yini Zhou9Rui Huang10Dongju Pan11Xueyu Li12Qiurong Li13Department of Paediatrics, Pu’er People’s HospitalDepartment of Paediatrics, Pu’er People’s HospitalDepartment of Paediatrics, Pu’er People’s HospitalDepartment of Infectious Diseases, Pu’er People’s HospitalDepartment of Paediatrics, Pu’er People’s HospitalDepartment of Paediatrics, Pu’er People’s HospitalGeneral Practice, Pu’er People’s HospitalDepartment of Paediatrics, Pu’er People’s HospitalDepartment of Anesthesiology, Pu’er People’s HospitalDepartment of Paediatrics, Pu’er People’s HospitalDepartment of Paediatrics, Pu’er People’s HospitalDepartment of Paediatrics, Pu’er People’s HospitalDepartment of Paediatrics, Pu’er People’s HospitalDepartment of Paediatrics, Pu’er People’s HospitalAbstract Background Tsutsugamushi, also known as bush typhus, is a naturally occurring disease caused by Orientia tsutsugamushi. We reported a case of vertical mother-to-newborn transmission of Orientia tsutsugamushi infection in a newborn from Yunnan (China). Case presentation Decreased fetal movements were observed at 39 weeks of gestation. After birth, the newborn (female) had recurrent fever, shortness of breath, and bruising around the mouth and extremities. At 5 h 58 min of age, the newborn was admitted for fever, shortness of breath and generalized rash. The liver was palpable 3 cm below the costal margin, and the limbs showed pitting edema. There was subcutaneous bleeding. Investigations suggested heavy infection, myocardial damage, decreased platelets. Treatment with cefotaxime and ampicillin failed. The mother was hospitalized at 29 weeks of gestation with a fever for 4 consecutive days, and an ulcerated crust was found in the popliteal fossa. Due to this pregnancy history, A diagnosis of Orientia tsutsugamushi infection was suspected in our index case and confirmed by macrogenomic testing and she was treated with vancomycin and meropenem, and later azithromycin for 1 week. The newborn was discharged in good general condition, gradually normalizing body temperature, and decreasing rash and jaundice. There were no abnormalities on subsequent blood macrogenomic tests for the baby. And one month later she showed good mental health, sleep, and food intake and no fever, rash, or jaundice. Conclusion Determining the cause of symptoms is the key to treating diseases, especially the rare diseases that can be misdiagnosed. Suitable for people with Infectious Diseases; Neonatology; Obstetrics.https://doi.org/10.1186/s12887-024-04561-0Tsutsugamushi diseaseMacrogenetic detectionNeonatesMeningitis, rickettsial disease |
| spellingShingle | Xu Yang Ling Zhang Shanping Chen Wei Chen Yushan Zhang Yi Zhang Jialong Liang Ying Lv Weiyan Wang Yini Zhou Rui Huang Dongju Pan Xueyu Li Qiurong Li A case of neonatal tsutsugamushi disease diagnosed with the aid of rickettsial macrogenomic detection BMC Pediatrics Tsutsugamushi disease Macrogenetic detection Neonates Meningitis, rickettsial disease |
| title | A case of neonatal tsutsugamushi disease diagnosed with the aid of rickettsial macrogenomic detection |
| title_full | A case of neonatal tsutsugamushi disease diagnosed with the aid of rickettsial macrogenomic detection |
| title_fullStr | A case of neonatal tsutsugamushi disease diagnosed with the aid of rickettsial macrogenomic detection |
| title_full_unstemmed | A case of neonatal tsutsugamushi disease diagnosed with the aid of rickettsial macrogenomic detection |
| title_short | A case of neonatal tsutsugamushi disease diagnosed with the aid of rickettsial macrogenomic detection |
| title_sort | case of neonatal tsutsugamushi disease diagnosed with the aid of rickettsial macrogenomic detection |
| topic | Tsutsugamushi disease Macrogenetic detection Neonates Meningitis, rickettsial disease |
| url | https://doi.org/10.1186/s12887-024-04561-0 |
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