Phosphorylation mutation impairs the promoting effect of spastin on neurite outgrowth without affecting its microtubule severing ability

Phosphorylation mutation impairs the promoting effect of spastin on neurite outgrowth without affecting its microtubule severing ability

Spastin, a microtubule-severing enzyme, is known to be important for neurite outgrowth. However, the role of spastin post-translational modification, particularly its phosphorylation regulation in neuronal outgrowth, remains unclear. This study aimed to investigate the effects of eliminating spasti...

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Bibliographic Details
Main Authors: Yunlong Zhang, Xin He, Jianyu Zou, Jie Yang, Ao Ma, Minghui Tan
Format: Article
Language:English
Published: PAGEPress Publications 2023-01-01
Series:European Journal of Histochemistry
Subjects:
Spastin
phosphorylation
hippocampal neurons
COS7
microtubule severing
neurite outgrowth
Online Access:https://www.ejh.it/index.php/ejh/article/view/3594

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