Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder
Dietary interventions for people suffering from major depressive disorder (MDD) are an ongoing field of research. In this article, we present a comprehensive background for understanding the possibility of using edible medicinal mushrooms as an adjunctive treatment for MDD. We start with a brief his...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/11/10/1489 |
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| author | Agata Fijałkowska Karol Jędrejko Katarzyna Sułkowska-Ziaja Marek Ziaja Katarzyna Kała Bożena Muszyńska |
| author_facet | Agata Fijałkowska Karol Jędrejko Katarzyna Sułkowska-Ziaja Marek Ziaja Katarzyna Kała Bożena Muszyńska |
| author_sort | Agata Fijałkowska |
| collection | DOAJ |
| description | Dietary interventions for people suffering from major depressive disorder (MDD) are an ongoing field of research. In this article, we present a comprehensive background for understanding the possibility of using edible medicinal mushrooms as an adjunctive treatment for MDD. We start with a brief history of MDD, its diagnosis, epidemiology and treatment, and the effects of diet on depression symptoms, followed by a review of neurobiological, behavioral, and clinical studies of medicinal mushrooms. We specifically highlight the results of preclinical and clinical studies on dietary supplementation with three selected mushroom species: Lion’s mane (<i>Hericium erinaceus</i>), Caterpillar mushroom (<i>Cordyceps militaris</i>), and Lingzhi/Reishi (<i>Ganoderma lucidum</i>). Preliminary small-sample clinical studies suggest that Lion’s mane can influence well-being of humans. In the case of Reishi, the results of clinical studies are equivocal, while in the case of Caterpillar Mushroom, such studies are underway. Edible mushrooms contain 5-hydroxy-L-tryptophan (5-HTP), which is a direct precursor of serotonin—a neurotransmitter targeted in pharmacotherapy of MDD. Therefore, in light of the well-recognized role of stress as a pathogenic factor of MDD, we also describe the neurobiological mechanisms of the interaction between stress and serotonergic neurotransmission; and summarize the current state of knowledge on dietary supplementation with 5-HTP in MDD. |
| first_indexed | 2024-03-10T03:54:34Z |
| format | Article |
| id | doaj.art-e2d4de3e30bc4a00ba1b553ce6047e47 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-10T03:54:34Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-e2d4de3e30bc4a00ba1b553ce6047e472023-11-23T10:59:53ZengMDPI AGFoods2304-81582022-05-011110148910.3390/foods11101489Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive DisorderAgata Fijałkowska0Karol Jędrejko1Katarzyna Sułkowska-Ziaja2Marek Ziaja3Katarzyna Kała4Bożena Muszyńska5Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, PolandDepartment of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, PolandDepartment of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, PolandDepartment of Histology, Faculty of Medicine, Jagiellonian University Medical College, Kopernika 7, 31-034 Kraków, PolandDepartment of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, PolandDepartment of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, PolandDietary interventions for people suffering from major depressive disorder (MDD) are an ongoing field of research. In this article, we present a comprehensive background for understanding the possibility of using edible medicinal mushrooms as an adjunctive treatment for MDD. We start with a brief history of MDD, its diagnosis, epidemiology and treatment, and the effects of diet on depression symptoms, followed by a review of neurobiological, behavioral, and clinical studies of medicinal mushrooms. We specifically highlight the results of preclinical and clinical studies on dietary supplementation with three selected mushroom species: Lion’s mane (<i>Hericium erinaceus</i>), Caterpillar mushroom (<i>Cordyceps militaris</i>), and Lingzhi/Reishi (<i>Ganoderma lucidum</i>). Preliminary small-sample clinical studies suggest that Lion’s mane can influence well-being of humans. In the case of Reishi, the results of clinical studies are equivocal, while in the case of Caterpillar Mushroom, such studies are underway. Edible mushrooms contain 5-hydroxy-L-tryptophan (5-HTP), which is a direct precursor of serotonin—a neurotransmitter targeted in pharmacotherapy of MDD. Therefore, in light of the well-recognized role of stress as a pathogenic factor of MDD, we also describe the neurobiological mechanisms of the interaction between stress and serotonergic neurotransmission; and summarize the current state of knowledge on dietary supplementation with 5-HTP in MDD.https://www.mdpi.com/2304-8158/11/10/1489<i>Cordyceps</i>major depressive disorderdiet<i>Hericium erinaceus</i>Reishiserotonin |
| spellingShingle | Agata Fijałkowska Karol Jędrejko Katarzyna Sułkowska-Ziaja Marek Ziaja Katarzyna Kała Bożena Muszyńska Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder Foods <i>Cordyceps</i> major depressive disorder diet <i>Hericium erinaceus</i> Reishi serotonin |
| title | Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder |
| title_full | Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder |
| title_fullStr | Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder |
| title_full_unstemmed | Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder |
| title_short | Edible Mushrooms as a Potential Component of Dietary Interventions for Major Depressive Disorder |
| title_sort | edible mushrooms as a potential component of dietary interventions for major depressive disorder |
| topic | <i>Cordyceps</i> major depressive disorder diet <i>Hericium erinaceus</i> Reishi serotonin |
| url | https://www.mdpi.com/2304-8158/11/10/1489 |
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