CRISPR/Cas9 editing reveals IRF8 regulated gene signatures restraining plasmablast differentiation

CRISPR/Cas9 editing reveals IRF8 regulated gene signatures restraining plasmablast differentiation

The transcription factor Interferon regulatory factor 8 (IRF8) is involved in maintaining B cell identity. However, how IRF8 regulates T cell independent B cell responses are not fully characterized. Here, an in vivo CRISPR/Cas9 system was optimized to generate Irf8-deficient murine B cells and used...

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Bibliographic Details
Main Authors: Zhihong Zuo, Anna K. Kania, Dillon G. Patterson, Sakeenah L. Hicks, Jeffrey Maurer, Mansi Gupta, Jeremy M. Boss, Christopher D. Scharer
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Heliyon
Subjects:
CRISPR/Cas9
Cas9 ribonucleoprotein
Gene editing
Hematopoietic stem cells
Primary mouse B cells
IRF8
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023047357

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