Tissue fluidity mediated by adherens junction dynamics promotes planar cell polarity-driven ommatidial rotation
Ommatidial rotation in the Drosophila eye is a regulated process and a Planar Cell Polarity (PCP) cell motility model. Here, the authors show that tissue fluidity via junctional remodeling, as regulated by the PCP effector kinase Nemo, is critical for this cell motility process.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-27253-0 |
| _version_ | 1818742196104331264 |
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| author | Nabila Founounou Reza Farhadifar Giovanna M. Collu Ursula Weber Michael J. Shelley Marek Mlodzik |
| author_facet | Nabila Founounou Reza Farhadifar Giovanna M. Collu Ursula Weber Michael J. Shelley Marek Mlodzik |
| author_sort | Nabila Founounou |
| collection | DOAJ |
| description | Ommatidial rotation in the Drosophila eye is a regulated process and a Planar Cell Polarity (PCP) cell motility model. Here, the authors show that tissue fluidity via junctional remodeling, as regulated by the PCP effector kinase Nemo, is critical for this cell motility process. |
| first_indexed | 2024-12-18T02:08:40Z |
| format | Article |
| id | doaj.art-e2d76438c92f4084b28793c08567e39a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T02:08:40Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e2d76438c92f4084b28793c08567e39a2022-12-21T21:24:32ZengNature PortfolioNature Communications2041-17232021-11-0112111610.1038/s41467-021-27253-0Tissue fluidity mediated by adherens junction dynamics promotes planar cell polarity-driven ommatidial rotationNabila Founounou0Reza Farhadifar1Giovanna M. Collu2Ursula Weber3Michael J. Shelley4Marek Mlodzik5Dept. of Cell, Developmental, & Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount SinaiCenter for Computational Biology, Flatiron Institute, Simons FoundationDept. of Cell, Developmental, & Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount SinaiDept. of Cell, Developmental, & Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount SinaiCenter for Computational Biology, Flatiron Institute, Simons FoundationDept. of Cell, Developmental, & Regenerative Biology, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount SinaiOmmatidial rotation in the Drosophila eye is a regulated process and a Planar Cell Polarity (PCP) cell motility model. Here, the authors show that tissue fluidity via junctional remodeling, as regulated by the PCP effector kinase Nemo, is critical for this cell motility process.https://doi.org/10.1038/s41467-021-27253-0 |
| spellingShingle | Nabila Founounou Reza Farhadifar Giovanna M. Collu Ursula Weber Michael J. Shelley Marek Mlodzik Tissue fluidity mediated by adherens junction dynamics promotes planar cell polarity-driven ommatidial rotation Nature Communications |
| title | Tissue fluidity mediated by adherens junction dynamics promotes planar cell polarity-driven ommatidial rotation |
| title_full | Tissue fluidity mediated by adherens junction dynamics promotes planar cell polarity-driven ommatidial rotation |
| title_fullStr | Tissue fluidity mediated by adherens junction dynamics promotes planar cell polarity-driven ommatidial rotation |
| title_full_unstemmed | Tissue fluidity mediated by adherens junction dynamics promotes planar cell polarity-driven ommatidial rotation |
| title_short | Tissue fluidity mediated by adherens junction dynamics promotes planar cell polarity-driven ommatidial rotation |
| title_sort | tissue fluidity mediated by adherens junction dynamics promotes planar cell polarity driven ommatidial rotation |
| url | https://doi.org/10.1038/s41467-021-27253-0 |
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