Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs
In recent years, IL-17A (IL-17), a pro-inflammatory cytokine, has received intense attention of researchers and clinicians alike with documented effects in inflammation and autoimmune diseases. IL-17 mobilizes, recruits and activates different cells to increase inflammation. Although protective in i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2015-07-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00236/full |
| _version_ | 1818314887420444672 |
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| author | Deena eKhan Deena eKhan S. Ansar eAhmed |
| author_facet | Deena eKhan Deena eKhan S. Ansar eAhmed |
| author_sort | Deena eKhan |
| collection | DOAJ |
| description | In recent years, IL-17A (IL-17), a pro-inflammatory cytokine, has received intense attention of researchers and clinicians alike with documented effects in inflammation and autoimmune diseases. IL-17 mobilizes, recruits and activates different cells to increase inflammation. Although protective in infections, overproduction of IL-17 promotes inflammation in autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, psoriasis, among others. Regulating IL-17 levels or action by using IL-17-blocking antibodies or IL-17R antagonist has shown to attenuate experimental autoimmune diseases. It is now known that in addition to IL-17-specific transcription factor, RORγt, several other transcription factors and select microRNAs (miRNA) regulate IL-17. Given that miRNAs are dysregulated in autoimmune diseases, a better understanding of transcriptional factors and miRNA regulation of IL-17 expression and function will be essential for devising potential new therapies. In this review, we will overview IL-17 induction and function in relation to autoimmune diseases. In addition, current findings on transcriptional regulation of IL-17 induction and plausible interplay between IL-17 and miRNA in autoimmune diseases are highlighted. |
| first_indexed | 2024-12-13T08:56:47Z |
| format | Article |
| id | doaj.art-e2da98956fb54c869eba285bd5f6b24c |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-13T08:56:47Z |
| publishDate | 2015-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-e2da98956fb54c869eba285bd5f6b24c2022-12-21T23:53:15ZengFrontiers Media S.A.Frontiers in Genetics1664-80212015-07-01610.3389/fgene.2015.00236138555Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAsDeena eKhan0Deena eKhan1S. Ansar eAhmed2Virginia TechCincinnati Children Hospital and Medical CenterVirginia TechIn recent years, IL-17A (IL-17), a pro-inflammatory cytokine, has received intense attention of researchers and clinicians alike with documented effects in inflammation and autoimmune diseases. IL-17 mobilizes, recruits and activates different cells to increase inflammation. Although protective in infections, overproduction of IL-17 promotes inflammation in autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, psoriasis, among others. Regulating IL-17 levels or action by using IL-17-blocking antibodies or IL-17R antagonist has shown to attenuate experimental autoimmune diseases. It is now known that in addition to IL-17-specific transcription factor, RORγt, several other transcription factors and select microRNAs (miRNA) regulate IL-17. Given that miRNAs are dysregulated in autoimmune diseases, a better understanding of transcriptional factors and miRNA regulation of IL-17 expression and function will be essential for devising potential new therapies. In this review, we will overview IL-17 induction and function in relation to autoimmune diseases. In addition, current findings on transcriptional regulation of IL-17 induction and plausible interplay between IL-17 and miRNA in autoimmune diseases are highlighted.http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00236/fullInflammationTranscription FactorsmicroRNAAutoimmuneIL-17 |
| spellingShingle | Deena eKhan Deena eKhan S. Ansar eAhmed Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs Frontiers in Genetics Inflammation Transcription Factors microRNA Autoimmune IL-17 |
| title | Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs |
| title_full | Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs |
| title_fullStr | Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs |
| title_full_unstemmed | Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs |
| title_short | Regulation of IL-17 in autoimmune diseases by transcriptional factors and microRNAs |
| title_sort | regulation of il 17 in autoimmune diseases by transcriptional factors and micrornas |
| topic | Inflammation Transcription Factors microRNA Autoimmune IL-17 |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00236/full |
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